ISCA1

ISCA1
Identifikatori
Aliasi	ISCA1
Vanjski ID-jevi	OMIM: 611006 MGI: 1916296 HomoloGene: 87862 GeneCards: ISCA1
Lokacija gena (čovjek)
Hrom.	Hromosom 9 (čovjek)
Kraj	86,283,102 bp
Lokacija gena (miš)
Hrom.	Hromosom 13 (miš)
Kraj	59,917,624 bp
Ontologija gena
Molekularna funkcija	• iron-sulfur cluster binding; • ferrous iron binding; • structural molecule activity; • vezivanje iona metala; • 2 iron, 2 sulfur cluster binding;
Ćelijska komponenta	• mitohondrija; • mitochondrial matrix;
Biološki proces	• iron-sulfur cluster assembly; • protein maturation by iron-sulfur cluster transfer; • small molecule metabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	81689
	69046
	ENSG00000135070
	ENSMUSG00000044792
	Q9BUE6
	Q9D924
	NM_030940
	NM_026921
	NP_112202
	NP_081197
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Mitohondrijski homolog sklopnog klastera gvožđe-sumpor jest evolucijski visoko konzervirani protein za biogenezu klastera gvožđe-sumpor mnoštva vrsta.^[5] Kod ljudi kodiran je genom ISCA1.^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135070 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044792 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Beilschmidt LK, Puccio HM (maj 2014). "Mammalian Fe-S cluster biogenesis and its implication in disease". Biochimie. 100: 48–60. doi:10.1016/j.biochi.2014.01.009. PMID 24440636.
^ Cózar-Castellano I, del Valle Machargo M, Trujillo E, Arteaga MF, González T, Martín-Vasallo P, Avila J (Aug 2004). "hIscA: a protein implicated in the biogenesis of iron-sulfur clusters". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1700 (2): 179–88. doi:10.1016/j.bbapap.2004.05.004. PMID 15262227.
^ "Entrez Gene: ISCA1 iron-sulfur cluster assembly 1 homolog (S. cerevisiae)".
^ "UniProt, Q9BUE6". Pristupljeno 9. 9. 2021.

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