JPH4

JPH4
Identifikatori
Aliasi	JPH4
Vanjski ID-jevi	MGI: 2443113 HomoloGene: 13034 GeneCards: JPH4
Lokacija gena (čovjek)
Hrom.	Hromosom 14 (čovjek)
Kraj	23,578,790 bp
Lokacija gena (miš)
Hrom.	Hromosom 14 (miš)
Kraj	55,354,392 bp
Ontologija gena
Molekularna funkcija	• calcium-release channel activity;
Ćelijska komponenta	• dendritic shaft; • integral component of membrane; • ćelijska membrana; • Endoplazmatski retikulum; • endoplasmic reticulum membrane; • membrana; • junctional sarcoplasmic reticulum membrane; • smooth endoplasmic reticulum; • junctional membrane complex;
Biološki proces	• regulation of ryanodine-sensitive calcium-release channel activity; • calcium ion transport into cytosol; • učenje; • neuromuscular process controlling balance; • regulation of synaptic plasticity; • GO:0032657 regulation of cytokine production; • regulation of store-operated calcium entry; • release of sequestered calcium ion into cytosol;
	Izvori:Amigo / QuickGO
Ortolozi
	84502
	319984
	ENSG00000092051
	ENSMUSG00000022208
	Q96JJ6
	Q80WT0
	NM_032452; NM_001146028
	NM_001003829; NM_177049
	NP_001139500; NP_115828
	NP_796023
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Junktofilin 4 je protein koji je kod ljudi kodiran genom JPH4. ^[5]

Ovaj gen kodira člana porodice junktofilinskih transmembranskih proteina koji su uključeni u stvaranje kompleksa spojnih membrana između plazmamembrane i endoplazme /
sarkoplazmatskog retikuluma u pobuđenimim ćelijama. Kodirani protein sadrži konzerviranu regiju ponavljanja N-kraja koja se naziva sekvencom zauzimanja i prepoznavanja neksusa membrane koja se nalazi u drugih članova porodice junktofilina. Alternativna prerada rezultira u više varijanti transkripta.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 628 aminokiselina, a molekulska težina 65.861 Da.^[6]

10	20	30	40	50
MSPGGKFDFD	DGGCYVGGWE	AGRAHGYGVC	TGPGAQGEYS	GCWAHGFESL
GVFTGPGGHS	YQGHWQQGKR	EGLGVERKSR	WTYRGEWLGG	LKGRSGVWES
VSGLRYAGLW	KDGFQDGYGT	ETYSDGGTYQ	GQWQAGKRHG	YGVRQSVPYH
QAALLRSPRR	TSLDSGHSDP	PTPPPPLPLP	GDEGGSPASG	SRGGFVLAGP
GDADGASSRK	RTPAAGGFFR	RSLLLSGLRA	GGRRSSLGSK	RGSLRSEVSS
EVGSTGPPGS	EASGPPAAAP	PALIEGSATE	VYAGEWRADR	RSGFGVSQRS
NGLRYEGEWL	GNRRHGYGRT	TRPDGSREEG	KYKRNRLVHG	GRVRSLLPLA
LRRGKVKEKV	DRAVEGARRA	VSAARQRQEI	AAARAADALL	KAVAASSVAE
KAVEAARMAK	LIAQDLQPML	EAPGRRPRQD	SEGSDTEPLD	EDSPGVYENG
LTPSEGSPEL	PSSPASSRQP	WRPPACRSPL	PPGGDQGPFS	SPKAWPEEWG
GAGAQAEELA	GYEAEDEAGM	QGPGPRDGSP	LLGGCSDSSG	SLREEEGEDE
EPLPPLRAPA	GTEPEPIAML	VLRGSSSRGP	DAGCLTEELG	EPAATERPAQ
PGAANPLVVG	AVALLDLSLA	FLFSQLLT

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference

1 2 3 GRCh38: Ensembl release 89: ENSG00000092051 - Ensembl, maj 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022208 - Ensembl, maj 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Junctophilin 4". Pristupljeno 13. 4. 2013.
↑ "UniProt, Q96JJ6". Pristupljeno 26. 7. 2021.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000092051 - Ensembl, maj 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022208 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Junctophilin 4". Pristupljeno 13. 4. 2013.

[UniProt-6] "UniProt, Q96JJ6". Pristupljeno 26. 7. 2021.

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