KDM7A

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KDM7A
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

3KV5, 3KV6, 3KV9, 3KVA, 3KVB, 3U78

Identifikatori
AliasiKDM7A
Vanjski ID-jeviMGI: 2443388 HomoloGene: 25281 GeneCards: KDM7A
Lokacija gena (čovjek)
Hromosom 7 (čovjek)
Hrom.Hromosom 7 (čovjek)[1]
Hromosom 7 (čovjek)
Genomska lokacija za KDM7A
Genomska lokacija za KDM7A
Bend7q34Početak140,084,746 bp[1]
Kraj140,176,983 bp[1]
Lokacija gena (miš)
Hromosom 6 (miš)
Hrom.Hromosom 6 (miš)[2]
Hromosom 6 (miš)
Genomska lokacija za KDM7A
Genomska lokacija za KDM7A
Bend6|6 B1Početak39,113,557 bp[2]
Kraj39,183,723 bp[2]
Ontologija gena
Molekularna funkcija• 2-oxoglutarate-dependent dioxygenase activity
• iron ion binding
• histone H3-methyl-lysine-9 demethylase activity
• histone H4-methyl-lysine-20 demethylase activity
• dioxygenase activity
• vezivanje iona metala
• methylated histone binding
• histone H3-methyl-lysine-36 demethylase activity
• oxidoreductase activity
• histone H3-tri/di-methyl-lysine-27 demethylase activity
• histone demethylase activity
• vezivanje iona cinka
Ćelijska komponenta• nukleoplazma
• Jedarce
• jedro
Biološki proces• GO:0009373 regulation of transcription, DNA-templated
• histone H3-K27 demethylation
• histone H3-K9 demethylation
• histone H4-K20 demethylation
• transcription, DNA-templated
• nervous system development
• GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
• histone H3-K36 demethylation
• midbrain development
• GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

80853

338523

Ensembl

ENSG00000006459

ENSMUSG00000042599

UniProt

Q6ZMT4

Q3UWM4

RefSeq (mRNK)

NM_030647

NM_001033430

RefSeq (bjelančevina)

NP_085150

NP_001028602

Lokacija (UCSC)Chr 7: 140.08 – 140.18 MbChr 6: 39.11 – 39.18 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Lizin-demetilaza 7A je protein/enzim koji je kod ljudi kodiran genom KDM7A.[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 941 aminokiselina, а molekulska težina 106.557 Da.[6]

1020304050
MAGAAAAVAAGAAAGAAAAAVSVAAPGRASAPPPPPPVYCVCRQPYDVNR
FMIECDICKDWFHGSCVGVEEHHAVDIDLYHCPNCAVLHGSSLMKKRRNW
HRHDYTEIDDGSKPVQAGTRTFIKELRSRVFPSADEIIIKMHGSQLTQRY
LEKHGFDVPIMVPKLDDLGLRLPSPTFSVMDVERYVGGDKVIDVIDVARQ
ADSKMTLHNYVKYFMNPNRPKVLNVISLEFSDTKMSELVEVPDIAKKLSW
VENYWPDDSVFPKPFVQKYCLMGVQDSYTDFHIDFGGTSVWYHVLWGEKI
FYLIKPTDENLARYESWSSSVTQSEVFFGDKVDKCYKCVVKQGHTLFVPT
GWIHAVLTSQDCMAFGGNFLHNLNIGMQLRCYEMEKRLKTPDLFKFPFFE
AICWFVAKNLLETLKELREDGFQPQTYLVQGVKALHTALKLWMKKELVSE
HAFEIPDNVRPGHLIKELSKVIRAIEEENGKPVKSQGIPIVCPVSRSSNE
ATSPYHSRRKMRKLRDHNVRTPSNLDILELHTREVLKRLEMCPWEEDILS
SKLNGKFNKHLQPSSTVPEWRAKDNDLRLLLTNGRIIKDERQPFADQSLY
TADSENEEDKRRTKKAKMKIEESSGVEGVEHEESQKPLNGFFTRVKSELR
SRSSGYSDISESEDSGPECTALKSIFTTEESESSGDEKKQEITSNFKEES
NVMRNFLQKSQKPSRSEIPIKRECPTSTSTEEEAIQGMLSMAGLHYSTCL
QRQIQSTDCSGERNSLQDPSSCHGSNHEVRQLYRYDKPVECGYHVKTEDP
DLRTSSWIKQFDTSRFHPQDLSRSQKCIRKEGSSEISQRVQSRNYVDSSG
SSLQNGKYMQNSNLTSGACQISNGSLSPERPVGETSFSVPLHPTKRPASN
PPPISNQATKGKRPKKGMATAKQRLGKILKLNRNGHARFFV

Reference[uredi | uredi izvor]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000006459 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042599 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Lysine demethylase 7A". Pristupljeno 9. 4. 2016.
  6. ^ "UniProt, Q6ZMT4" (jezik: engleski). Pristupljeno 25. 9. 2021.

Dopunska literatura[uredi | uredi izvor]

Vanjski linkovi[uredi | uredi izvor]

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Lysine-specific demethylase 7A (KDM7A)
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