Kaspaza-10

Kaspaza-10
Identifikatori
Aliasi	CASP10
Vanjski ID-jevi	OMIM: 601762 HomoloGene: 50038 GeneCards: CASP10
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	201,229,428 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• death effector domain binding; • GO:0070122 peptidase activity; • cysteine-type peptidase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • hydrolase activity; • ubiquitin protein ligase binding; • cysteine-type endopeptidase activity involved in execution phase of apoptosis; • cysteine-type endopeptidase activity; • cysteine-type endopeptidase activity involved in apoptotic signaling pathway; • cysteine-type endopeptidase activity involved in apoptotic process;
Ćelijska komponenta	• ripoptosome; • citosol; • CD95 death-inducing signaling complex; • citoplazma;
Biološki proces	• positive regulation of I-kappaB kinase/NF-kappaB signaling; • apoptotic signaling pathway; • cell surface receptor signaling pathway; • Proteoliza; • GO:0097285 apoptoza; • regulation of apoptotic process; • execution phase of apoptosis; • activation of cysteine-type endopeptidase activity involved in apoptotic process;
	Izvori:Amigo / QuickGO
Ortolozi
	843
	n/a
	ENSG00000003400
	n/a
	Q92851
	n/a
NM_001206524; NM_001206542; NM_001230; NM_001306083; NM_032974;
	NM_032976; NM_032977
	n/a
NP_001193453; NP_001193471; NP_001221; NP_001293012; NP_116756;
	NP_116758; NP_116759
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Kaspaza-10 jest enzim koji je kod ljudi kodiran genom CASP10 sa hromosoma 2.^[3]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 521 aminokiselina, a molekulska težina 58.951 Da.^[3]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKSQGQHWYS	SSDKNCKVSF	REKLLIIDSN	LGVQDVENLK	FLCIGLVPNK
KLEKSSSASD	VFEHLLAEDL	LSEEDPFFLA	ELLYIIRQKK	LLQHLNCTKE
EVERLLPTRQ	RVSLFRNLLY	ELSEGIDSEN	LKDMIFLLKD	SLPKTEMTSL
SFLAFLEKQG	KIDEDNLTCL	EDLCKTVVPK	LLRNIEKYKR	EKAIQIVTPP
VDKEAESYQG	EEELVSQTDV	KTFLEALPQE	SWQNKHAGSN	GNRATNGAPS
LVSRGMQGAS	ANTLNSETST	KRAAVYRMNR	NHRGLCVIVN	NHSFTSLKDR
QGTHKDAEIL	SHVFQWLGFT	VHIHNNVTKV	EMEMVLQKQK	CNPAHADGDC
FVFCILTHGR	FGAVYSSDEA	LIPIREIMSH	FTALQCPRLA	EKPKLFFIQA
CQGEEIQPSV	SIEADALNPE	QAPTSLQDSI	PAEADFLLGL	ATVPGYVSFR
HVEEGSWYIQ	SLCNHLKKLV	PRMLKFLEKT	MEIRGRKRTV	WGAKQISATS
LPTAISAQTP	RPPMRRWSSV	S

Funkcija[uredi | uredi izvor]

Ovaj gen kodira protein koji je član porodice cistein-asparaginskokiselinskih kaspaza. Sekvencna aktivacija kaspaza ima centralnu ulogu u fazi izvršenja apoptoze ćelije. Kaspaze postoje kao neaktivni proenzimi koji se podvrgavaju proteolitskoj obradi na konzerviranim asparaginskim ostacima kako bi se proizvele dvije podjedinice, velika i mala, koje se dimeriziraju i formiraju aktivni enzim. Ovaj protein cijepa i aktivira kaspaze 3 i 7, a sam protein se obrađuje kaspazom 8. Mutacije ovog gena su povezane sa defektima apoptoze koji se vide kod autoimunskog limfoproliferativnog sindroma tipa II. Za ovaj gen su opisane tri alternativno prerađene varijante transkripta koje kodiraju različite izoforme.^[4]

Interakcije[uredi | uredi izvor]

Pokazalo se da kaspaza 10 ima interakcije sa FADD,^[5]^[6]^[7]^[8] CFLAR,^[7]^[9]^[10] kaspaza-8,^[5]^[9]^[11]^[12] Fas receptorom,^[5]^[6]^[13] RYBP,^[14] TNFRSF1A^[5]^[6] i TNFRSF10B.^[5]^[13]

Također pogledajte[uredi | uredi izvor]

Referenc[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000003400 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Fernandes-Alnemri T, Armstrong RC, Krebs J, Srinivasula SM, Wang L, Bullrich F, Fritz LC, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES (oktobar 1996). "In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains". Proc Natl Acad Sci USA. 93 (15): 7464–9. Bibcode:1996PNAS...93.7464F. doi:10.1073/pnas.93.15.7464. PMC 38767. PMID 8755496.
^ "Entrez Gene: CASP10 caspase 10, apoptosis-related cysteine peptidase".
^ ^a ^b ^c ^d ^e Gajate, Consuelo; Mollinedo Faustino (mart 2005). "Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy". J. Biol. Chem. United States. 280 (12): 11641–7. doi:10.1074/jbc.M411781200. ISSN 0021-9258. PMID 15659383.
^ ^a ^b ^c Vincenz, C; Dixit V M (mart 1997). "Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling". J. Biol. Chem. UNITED STATES. 272 (10): 6578–83. doi:10.1074/jbc.272.10.6578. ISSN 0021-9258. PMID 9045686.
^ ^a ^b Srinivasula SM, Ahmad M, Ottilie S, Bullrich F, Banks S, Wang Y, Fernandes-Alnemri T, Croce CM, Litwack G, Tomaselli KJ, Armstrong RC, Alnemri ES (juli 1997). "FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis". J. Biol. Chem. UNITED STATES. 272 (30): 18542–5. doi:10.1074/jbc.272.30.18542. ISSN 0021-9258. PMID 9228018.
^ Wang, J; Chun H J; Wong W; Spencer D M; Lenardo M J (novembar 2001). "Caspase-10 is an initiator caspase in death receptor signaling". Proc. Natl. Acad. Sci. U.S.A. United States. 98 (24): 13884–8. Bibcode:2001PNAS...9813884W. doi:10.1073/pnas.241358198. ISSN 0027-8424. PMC 61136. PMID 11717445.
^ ^a ^b Micheau, Olivier; Tschopp Jürg (juli 2003). "Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes". Cell. United States. 114 (2): 181–90. doi:10.1016/S0092-8674(03)00521-X. ISSN 0092-8674. PMID 12887920.
^ Goltsev, Y V; Kovalenko A V; Arnold E; Varfolomeev E E; Brodianskii V M; Wallach D (august 1997). "CASH, a novel caspase homologue with death effector domains". J. Biol. Chem. United States. 272 (32): 19641–4. doi:10.1074/jbc.272.32.19641. ISSN 0021-9258. PMID 9289491.
^ Guo, Yin; Srinivasula Srinivasa M; Druilhe Anne; Fernandes-Alnemri Teresa; Alnemri Emad S (april 2002). "Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria". J. Biol. Chem. United States. 277 (16): 13430–7. doi:10.1074/jbc.M108029200. ISSN 0021-9258. PMID 11832478.
^ Srinivasula, S M; Ahmad M; Fernandes-Alnemri T; Litwack G; Alnemri E S (decembar 1996). "Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases". Proc. Natl. Acad. Sci. U.S.A. United States. 93 (25): 14486–91. Bibcode:1996PNAS...9314486S. doi:10.1073/pnas.93.25.14486. ISSN 0027-8424. PMC 26159. PMID 8962078.
^ ^a ^b MacFarlane, M; Ahmad M; Srinivasula S M; Fernandes-Alnemri T; Cohen G M; Alnemri E S (oktobar 1997). "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL". J. Biol. Chem. United States. 272 (41): 25417–20. doi:10.1074/jbc.272.41.25417. ISSN 0021-9258. PMID 9325248.
^ Zheng, L; Schickling O; Peter M E; Lenardo M J (august 2001). "The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm". J. Biol. Chem. United States. 276 (34): 31945–52. doi:10.1074/jbc.M102799200. ISSN 0021-9258. PMID 11395500.

Dopunska literatura[uredi | uredi izvor]

Cohen GM (1997). "Caspases: the executioners of apoptosis". Biochem. J. 326 (Pt 1): 1–16. doi:10.1042/bj3260001. PMC 1218630. PMID 9337844.
Clements GB, Klein G, Povey S (1975). "Production by EBV infection of an EBNA-positive subline from an EBNA-negative human lymphoma cell line without detectable EBV DNA". Int. J. Cancer. 16 (1): 125–33. doi:10.1002/ijc.2910160114. PMID 170210. S2CID 30408863.
Baumann K, de Rouffignac C, Roinel N, et al. (1975). "Renal phosphate transport: inhomogeneity of local proximal transport rates and sodium dependence". Pflügers Arch. 356 (4): 287–98. doi:10.1007/BF00580003. PMID 1171445. S2CID 259484.
DuBridge RB, Tang P, Hsia HC, et al. (1987). "Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system". Mol. Cell. Biol. 7 (1): 379–87. doi:10.1128/mcb.7.1.379. PMC 365079. PMID 3031469.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Fernandes-Alnemri T, Takahashi A, Armstrong R, et al. (1996). "Mch3, a novel human apoptotic cysteine protease highly related to CPP32". Cancer Res. 55 (24): 6045–52. PMID 8521391.
Srinivasula SM, Ahmad M, Fernandes-Alnemri T, et al. (1997). "Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases". Proc. Natl. Acad. Sci. U.S.A. 93 (25): 14486–91. Bibcode:1996PNAS...9314486S. doi:10.1073/pnas.93.25.14486. PMC 26159. PMID 8962078.
Vincenz C, Dixit VM (1997). "Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling". J. Biol. Chem. 272 (10): 6578–83. doi:10.1074/jbc.272.10.6578. PMID 9045686.
Bourquin JP, Stagljar I, Meier P, et al. (1997). "A serine/arginine-rich nuclear matrix cyclophilin interacts with the C-terminal domain of RNA polymerase II". Nucleic Acids Res. 25 (11): 2055–61. doi:10.1093/nar/25.11.2055. PMC 146702. PMID 9153302.
Shu HB, Halpin DR, Goeddel DV (1997). "Casper is a FADD- and caspase-related inducer of apoptosis". Immunity. 6 (6): 751–63. doi:10.1016/S1074-7613(00)80450-1. PMID 9208847.
Srinivasula SM, Ahmad M, Ottilie S, et al. (1997). "FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis". J. Biol. Chem. 272 (30): 18542–5. doi:10.1074/jbc.272.30.18542. PMID 9228018.
Goltsev YV, Kovalenko AV, Arnold E, et al. (1997). "CASH, a novel caspase homologue with death effector domains". J. Biol. Chem. 272 (32): 19641–4. doi:10.1074/jbc.272.32.19641. PMID 9289491.
MacFarlane M, Ahmad M, Srinivasula SM, et al. (1997). "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL". J. Biol. Chem. 272 (41): 25417–20. doi:10.1074/jbc.272.41.25417. PMID 9325248.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hu S, Snipas SJ, Vincenz C, et al. (1998). "Caspase-14 is a novel developmentally regulated protease". J. Biol. Chem. 273 (45): 29648–53. doi:10.1074/jbc.273.45.29648. PMID 9792675.
Ng PW, Porter AG, Jänicke RU (1999). "Molecular cloning and characterization of two novel pro-apoptotic isoforms of caspase-10". J. Biol. Chem. 274 (15): 10301–8. doi:10.1074/jbc.274.15.10301. PMID 10187817.
Wang J, Zheng L, Lobito A, et al. (1999). "Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II". Cell. 98 (1): 47–58. doi:10.1016/S0092-8674(00)80605-4. PMID 10412980.
Satoh S, Hijikata M, Handa H, Shimotohno K (1999). "Caspase-mediated cleavage of eukaryotic translation initiation factor subunit 2alpha". Biochem. J. 342 (Pt 1): 65–70. doi:10.1042/0264-6021:3420065. PMC 1220437. PMID 10432301.

Vanjski linkovi[uredi | uredi izvor]

GeneReviews/NCBI/NIH/UW entry on Autoimmune Lymphoproliferative Syndrome
The MEROPS online database for peptidases and their inhibitors: C14.011^{[mrtav link]}

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000003400 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8755496-3] Fernandes-Alnemri T, Armstrong RC, Krebs J, Srinivasula SM, Wang L, Bullrich F, Fritz LC, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES (oktobar 1996). "In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains". Proc Natl Acad Sci USA. 93 (15): 7464–9. Bibcode:1996PNAS...93.7464F. doi:10.1073/pnas.93.15.7464. PMC 38767. PMID 8755496.

[entrez-4] "Entrez Gene: CASP10 caspase 10, apoptosis-related cysteine peptidase".

[pmid15659383-5] Gajate, Consuelo; Mollinedo Faustino (mart 2005). "Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy". J. Biol. Chem. United States. 280 (12): 11641–7. doi:10.1074/jbc.M411781200. ISSN 0021-9258. PMID 15659383.

[pmid9045686-6] Vincenz, C; Dixit V M (mart 1997). "Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling". J. Biol. Chem. UNITED STATES. 272 (10): 6578–83. doi:10.1074/jbc.272.10.6578. ISSN 0021-9258. PMID 9045686.

[pmid9228018-7] Srinivasula SM, Ahmad M, Ottilie S, Bullrich F, Banks S, Wang Y, Fernandes-Alnemri T, Croce CM, Litwack G, Tomaselli KJ, Armstrong RC, Alnemri ES (juli 1997). "FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis". J. Biol. Chem. UNITED STATES. 272 (30): 18542–5. doi:10.1074/jbc.272.30.18542. ISSN 0021-9258. PMID 9228018.

[pmid11717445-8] Wang, J; Chun H J; Wong W; Spencer D M; Lenardo M J (novembar 2001). "Caspase-10 is an initiator caspase in death receptor signaling". Proc. Natl. Acad. Sci. U.S.A. United States. 98 (24): 13884–8. Bibcode:2001PNAS...9813884W. doi:10.1073/pnas.241358198. ISSN 0027-8424. PMC 61136. PMID 11717445.

[pmid12887920-9] Micheau, Olivier; Tschopp Jürg (juli 2003). "Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes". Cell. United States. 114 (2): 181–90. doi:10.1016/S0092-8674(03)00521-X. ISSN 0092-8674. PMID 12887920.

[pmid9289491-10] Goltsev, Y V; Kovalenko A V; Arnold E; Varfolomeev E E; Brodianskii V M; Wallach D (august 1997). "CASH, a novel caspase homologue with death effector domains". J. Biol. Chem. United States. 272 (32): 19641–4. doi:10.1074/jbc.272.32.19641. ISSN 0021-9258. PMID 9289491.

[pmid11832478-11] Guo, Yin; Srinivasula Srinivasa M; Druilhe Anne; Fernandes-Alnemri Teresa; Alnemri Emad S (april 2002). "Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria". J. Biol. Chem. United States. 277 (16): 13430–7. doi:10.1074/jbc.M108029200. ISSN 0021-9258. PMID 11832478.

[pmid8962078-12] Srinivasula, S M; Ahmad M; Fernandes-Alnemri T; Litwack G; Alnemri E S (decembar 1996). "Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases". Proc. Natl. Acad. Sci. U.S.A. United States. 93 (25): 14486–91. Bibcode:1996PNAS...9314486S. doi:10.1073/pnas.93.25.14486. ISSN 0027-8424. PMC 26159. PMID 8962078.

[pmid9325248-13] MacFarlane, M; Ahmad M; Srinivasula S M; Fernandes-Alnemri T; Cohen G M; Alnemri E S (oktobar 1997). "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL". J. Biol. Chem. United States. 272 (41): 25417–20. doi:10.1074/jbc.272.41.25417. ISSN 0021-9258. PMID 9325248.

[pmid11395500-14] Zheng, L; Schickling O; Peter M E; Lenardo M J (august 2001). "The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm". J. Biol. Chem. United States. 276 (34): 31945–52. doi:10.1074/jbc.M102799200. ISSN 0021-9258. PMID 11395500.

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p r u Proteaza: Cisteinska proteaza (EC 3.4.22)
Kaspaza	Kaspaza-1 Kaspaza-2 Kaspaza-3 Kaspaza-4 Kaspaza-5 Kaspaza-6 Kaspaza-7 Kaspaza-8 Kaspaza-9 Kaspaza-10 Kaspaza-12 Kaspaza-13 Kaspaza-14
Izvedene iz plodova	Papain Fikain Bromelain Aktinidain
Kalpain	CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPNS1 CAPNS2
Katepsin	B C F H K L1/L2 O S W Z
Ostale	Klostripain Kancerski prokoagulant Separaza Autofagin Kruzipain 3C-lika proteaza