Kaspaza-14

Kaspaza-14
Identifikatori
Aliasi	CASP14
Vanjski ID-jevi	OMIM: 605848 MGI: 1335092 HomoloGene: 36304 GeneCards: CASP14
Lokacija gena (čovjek) Hrom. Hromosom 19 (čovjek) Bend 19p13.12 Početak 15,049,480 bp Kraj 15,058,293 bp
Lokacija gena (miš) Hrom. Hromosom 10 (miš) Bend 10|10 C1 Početak 78,547,825 bp Kraj 78,554,128 bp
Ontologija gena Molekularna funkcija • GO:0070122 peptidase activity • cysteine-type endopeptidase activity • cysteine-type peptidase activity • GO:0001948, GO:0016582 vezivanje za proteine • hydrolase activity • endopeptidase activity • cysteine-type endopeptidase activity involved in execution phase of apoptosis • cysteine-type endopeptidase activity involved in apoptotic process Ćelijska komponenta • citoplazma • keratin filament • jedro • citosol • mitohondrija Biološki proces • cornification • Ćelijska diferencijacija • keratinization • Proteoliza • epidermis development • execution phase of apoptosis • GO:0097285 apoptoza • intrinsic apoptotic signaling pathway in response to DNA damage Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	23581	12365
Ensembl	ENSG00000105141	ENSMUSG00000005355
UniProt	P31944	O89094
RefSeq (mRNK)	NM_012114	NM_009809
RefSeq (bjelančevina)	NP_036246	NP_033939
Lokacija (UCSC)	Chr 19: 15.05 – 15.06 Mb	Chr 10: 78.55 – 78.55 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Kaspaza-14 jest enzim koji je kod ljudi kodiran genom CASP14 sa hromosoma 19.

Funkcija

Gen CASP14 kodira člana porodice cistein-aspartanih proteaza (kaspaza). Sekvencna aktivacija kaspaza ima centralnu ulogu u fazi izvršenja ćelijske apoptoze. Kaspaze postoje kao neaktivni proenzimi koji se podvrgavaju proteolitskoj obradi na konzerviranim asparaginskim ostacima kako bi se dobile dvije podjedinice, veliku i malu, koje se dimeriziraju i formiraju aktivni enzim. Pokazalo se da je ova kaspaza obrađena i aktivirana pomoću kaspaze-8 i 10 in vitro, i anti-Fas agonističkog antitijela ili TNF-ove apoptoze koja indukuje ligand in vivo. Ekspresija i obrada ove kaspaze može biti uključena u keratinocitnu terminalnu diferencijaciju, što je važno za formiranje kožne barijere.

Prema Atlasu ljudskih proteina, CASP14 proteinom je obogaćena ljudska koža i uglavnom je eksprimiran u gornjim slojevima epiderme. Prema Atlasu ćelija, protein je uglavnom lokalizovan u citosolu.

Također pogledajte

• Proteolizni MAP
• Kaspaza

Dopunska literatura

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Vanjski linkovi

• The MEROPS online database for peptidases and their inhibitors: C14.018 Arhivirano 24. 10. 2007. na Wayback Machine