Katepsin B

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Katepsin B
PDB 1csb EBI.jpg
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

3PBH, 1CSB, 1GMY, 1HUC, 1PBH, 2IPP, 2PBH, 3AI8, 3CBJ, 3CBK, 3K9M

Identifikatori
AliasiCTSB
Vanjski ID-jeviOMIM: 116810 MGI: 88561 HomoloGene: 37550 GeneCards: CTSB
Lokacija gena (čovjek)
Hromosom 8 (čovjek)
Hrom.Hromosom 8 (čovjek)[1]
Hromosom 8 (čovjek)
Genomska lokacija za Katepsin B
Genomska lokacija za Katepsin B
Bend8p23.1Početak11,842,524 bp[1]
Kraj11,869,448 bp[1]
Lokacija gena (miš)
Hromosom 14 (miš)
Hrom.Hromosom 14 (miš)[2]
Hromosom 14 (miš)
Genomska lokacija za Katepsin B
Genomska lokacija za Katepsin B
Bend14 D1|14 33.24 cMPočetak63,359,911 bp[2]
Kraj63,383,372 bp[2]
Obrazac RNK ekspresije
PBB GE CTSB 213274 s at fs.png

PBB GE CTSB 200838 at fs.png

PBB GE CTSB 200839 s at fs.png
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija cysteine-type peptidase activity
collagen binding
GO:0070122 peptidase activity
GO:0001948, GO:0016582 protein binding
cysteine-type endopeptidase activity
hydrolase activity
proteoglycan binding
serine-type endopeptidase activity
endopeptidase activity
Ćelijska komponenta intracellular membrane-bounded organelle
Melanosom
intracellular anatomical structure
extracellular region
endolysosome lumen
Jedarce
mitohondrija
Lizozom
Egzosom
perinuklearno područje citoplazme
Vanćelijsko
ficolin-1-rich granule lumen
collagen-containing extracellular matrix
Biološki proces regulation of apoptotic process
epithelial cell differentiation
Proteoliza
toll-like receptor signaling pathway
decidualization
cellular response to thyroid hormone stimulus
collagen catabolic process
viral entry into host cell
GO:0048552 regulation of catalytic activity
proteolysis involved in cellular protein catabolic process
neutrophil degranulation
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_001908
NM_147780
NM_147781
NM_147782
NM_147783

NM_001317237

NM_007798

RefSeq (bjelančevina)
NP_001304166
NP_001899
NP_680090
NP_680091
NP_680092

NP_680093

NP_031824

Lokacija (UCSC)Chr 8: 11.84 – 11.87 MbChr 14: 63.36 – 63.38 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Katepsin B (EC 3.4.22.1katepsin B1 ili katepsin II – je enzim iz superfamilije peptidaza, familija papaina.[5][6][7][8][9][10][11][12] katalizira slijedeću hemijsku reakciju:

Hidroliza proteina široke specifičnosti peptidnih veza. Prvenstveno razlaže -Arg- -Arg- veze u malim molekulama supstrata, po čeme se razlikuje od katepsina L.

Reference[uredi | uredi izvor]

  1. ^ a b c ENSG00000285132 GRCh38: Ensembl release 89: ENSG00000164733, ENSG00000285132 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021939 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cornish-Bowden A. (2004): Fundamentals of enzyme kinetics, 3rd Ed. Portland Press. ISBN 9781855781580; ISBN 1855781581.
  6. ^ Međedović S., Maslić E., Hadžiselimović R. (2000): Biologija 2. Svjetlost, Sarajevo, ISBN 9958-10-222-6.
  7. ^ Bajrović K, Jevrić-Čaušević A., Hadžiselimović R., Ed. (2005): Uvod u genetičko inženjerstvo i biotehnologiju. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 9958-9344-1-8.
  8. ^ Bond, J.S. and Barrett, A.J. (1980). "Degradation of fructose-1,6-bisphosphate aldolase by cathepsin B. A further example of peptidyldipeptidase activity of this proteinase". Biochem. J. 189: 17–25. PMID 7458901.CS1 održavanje: više imena: authors list (link)
  9. ^ Barrett, A.J. , Kirschke, H. (1981). "Cathepsin B, cathepsin H and cathepsin L". Methods Enzymol. 80: 535–561. PMID 7043200.CS1 održavanje: više imena: authors list (link)
  10. ^ Polgár, L. and Csoma, C. (1987). "Dissociation of ionizing groups in the binding cleft inversely controls the endo- and exopeptidase activities of cathepsin B". J. Biol. Chem. 262: 14448–14453. PMID 3312190.CS1 održavanje: više imena: authors list (link)
  11. ^ Barrett, A.J., Buttle, D.J. and Mason, R.W. (1988). "Lysosomal cysteine proteinases". ISI Atlas of Science. Biochemistry. 1: 256–260.CS1 održavanje: više imena: authors list (link)
  12. ^ Kirschke, H., Wikstrom, P. and Shaw, E. (1988). "Active center differences between cathepsins L and B: the S1 binding region". FEBS Lett. 228: 128–130. PMID 3342870.CS1 održavanje: više imena: authors list (link)

Vanjski linkovi[uredi | uredi izvor]