S Wikipedije, slobodne enciklopedije
Druga imena IUPAC ime: L -arginil-L -prolil-L -valil-L -lizil-L -valil-L -tirozil-L -prolil-L -asparaginil-L -glicil-L -alanil-L -α-glutamil-L -α-aspartil-L -α-glutamil-L -seril-L -alanil-L -α-glutamil-L -alanil-L -fenilalanil-L -prolil-L -leucil-L -α-glutamil-L -fenilalaninMolekularna formula C112 H165 N27 O36 CAS registarski broj 53917-42-3 Molarna masa 2465,668 g/mol 1 Gdje god je moguće korištene su SI jedinice. Ako nije drugačije naznačeno, dati podaci vrijede pri standardnim uslovima.
Kod čovjeka, genski lokus POMC je na kratkom (p) kraku hromosomu 2 : pozicija 2p.23 Kortikotropinoliki intermedijarni peptid (CLIP ), poznat i kao fragment adrenokortikotropnog hormona 18-39 [ACTH (18-39 )], je koji se prirodno pojavljuje kao endogeni neuropeptid sa dokosapeptidnom strukturom i sekvencom aminokiselina : Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe. CLIP nastaje kao proizvod cijepanja veza u proteolizi fadenokortikotropnog hormona (ACTH),[1] [2] proopiomelanokortina (POMC).[3] [4] [5] centralnom nervnom sistemu .[6] [7] [8] [9] [10]
^ Gianoulakis C, Seidah NG, Routhier R, Chrétien M (decembar 1979). "Biosynthesis and characterization of adrenocorticotropic hormone, alpha-melanocyte-stimulating hormone, and an NH2-terminal fragment of the adrenocorticotropic hormone/beta-lipotropin precursor from rat pars intermedia" . The Journal of Biological Chemistry . 254 (23): 11903–6. PMID 227883 . Arhivirano s originala , 15. 9. 2019. Pristupljeno 27. 8. 2020 . ^ Lloyd D. Fricker (24. 7. 1991). Peptide biosynthesis and processing ISBN 978-0-8493-8852-1 . Pristupljeno 25. 11. 2011 . ^ Anthony W. Norman; Gerald Litwack (26. 9. 1997). Hormones 12 . ISBN 978-0-12-521441-4 . Pristupljeno 25. 11. 2011 . ^ Marshall JB, Kapcala LP, Manning LD, McCullough AJ (novembar 1984). "Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules" . The Journal of Clinical Investigation . 74 (5): 1886–9. doi :10.1172/JCI111608 . PMC 425369 PMID 6209301 . ^ Zaphiropoulos A, Charnay Y, Vallet P, Constantinidis J, Bouras C (januar 1991). "Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain" . Brain Research Bulletin . 26 (1): 99–111. doi :10.1016/0361-9230(91)90194-O . PMID 1849784 . ^ Shojiro Inoué; Shojiro Inoué (1989). Biology of sleep substances ISBN 978-0-8493-4822-8 . Pristupljeno 25. 11. 2011 . ^ Chastrette N, Cespuglio R, Jouvet M (februar 1990). "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 1--Hypnogenic properties of ACTH derivatives" . Neuropeptides . 15 (2): 61–74. doi :10.1016/0143-4179(90)90042-w . PMID 1981927 . ^ Chastrette N, Cespuglio R, Lin YL, Jouvet M (februar 1990). "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 2--Aminergic regulatory processes" . Neuropeptides . 15 (2): 75–88. doi :10.1016/0143-4179(90)90043-x . PMID 1964203 . ^ Grigoriev VV, Petrova LN, Ivanova TA, Gabreliyan AV, Serkova TP (mart 2009). "Effect of corticotropin-like intermediate lobe peptide on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in rat brain". Bulletin of Experimental Biology and Medicine . 147 (3): 319–22. doi :10.1007/s10517-009-0499-x . PMID 19529852 . ^ Seidenbecher T, Balschun D, Vogel D, Reymann KG (1993). "Neuronal transmission of hippocampal CA1 neurones is modulated by corticotropin-like intermediate lobe peptide [CLIP; ACTH(18-39)]". Peptides . 14 (6): 1221–4. doi :10.1016/0196-9781(93)90179-K . PMID 8134304 .
