L1TD1

L1TD1
Dostupne strukture
PDB	Pretraga Human UniProta: PDBe RCSB
Spisak PDB ID kodova
	2LR6, 3SOO
Identifikatori
Aliasi	L1TD1
Vanjski ID-jevi	HomoloGene: 136289 GeneCards: L1TD1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	62,212,328 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• single-stranded RNA binding; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• ribonukleoprotein;
Biološki proces	• transposition, RNA-mediated;
	Izvori:Amigo / QuickGO
Ortolozi
	54596
	n/a
	ENSG00000240563
	n/a
	Q5T7N2
	n/a
	NM_019079; NM_001164835
	n/a
	NP_001158307; NP_061952
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

LINE-1 tip transposaze sa domenom 1, znan i kao L1TD1, jest protein koji je kod ljudi kodiran genom L1TD1 sa hromosoma 1.

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 865 aminokiselina, a molekulska težina 98.850 Da.^[3].

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSDVSTSVQS	KFARLAKKKE	NITYMKREQL	TETDKDIAPV	LDLKCKDVSA
IMNKFKVLME	IQDLMFEEMR	ETLKNDLKAV	LGGKATIPEV	KNSENSSSRT
EFQQIINLAL	QKTGMVGKIE	GENSKIGDDN	ENLTFKLEVN	ELSGKLDNTN
EYNSNDGKKL	PQGESRSYEV	MGSMEETLCN	IDDRDGNRNV	HLEFTERESR
KDGEDEFVKE	MREERKFQKL	KNKEEVLKAS	REEKVLMDEG	AVLTLVADLS
SATLDISKQW	SNVFNILREN	DFEPKFLCEV	KLAFKCDGEI	KTFSDLQSLR
KFASQKSSVK	ELLKDVLPQK	EEINQGGRKY	GIQEKRDKTL	IDSKHRAGEI
TSDGLSFLFL	KEVKVAKPEE	MKNLETQEEE	FSELEELDEE	ASGMEDDEDT
SGLEEEEEEP	SGLEEEEEEE	ASGLEEDEAS	GLEEEEEQTS	EQDSTFQGHT
LVDAKHEVEI	TSDGMETTFI	DSVEDSESEE	EEEGKSSETG	KVKTTSLTEK
KASRRQKEIP	FSYLVGDSGK	KKLVKHQVVH	KTQEEEETAV	PTSQGTGTPC
LTLCLASPSK	SLEMSHDEHK	KHSHTNLSIS	TGVTKLKKTE	EKKHRTLHTE
ELTSKEADLT	EETEENLRSS	VINSIREIKE	EIGNLKSSHS	GVLEIENSVD
DLSSRMDILE	ERIDSLEDQI	EEFSKDTMQM	TKQIISKERQ	RDIEERSRSC
NIRLIGIPEK	ESYENRAEDI	IKEIIDENFA	ELKKGSSLEI	VSACRVPSKI
DEKRLTPRHI	LVKFWNSSDK	EKIIRASRER	REITYQGTRI	RLTADLSLDT
LDARSKWSNV	FKVLLEKGFN	PRILYPAKMA	FDFRGKTKVF	LSIEEFRDYV
LHMPTLRELL	GNNIP

Funkcija[uredi | uredi izvor]

L1TD1 je RNK-vezujući protein koji je uključen u samoobnavljanje nediferenciranih ljudskih embrionskih matičnih ćelija i proliferacije ćelija raka. Prijavljeno je da je L1TD1 povezan s razvojem nekoliko karcinoma. ^[4] ^[5] ^[6] ^[7]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000240563 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "UniProt, Q5T7N2" (jezik: eng.). Pristupljeno 29. 11. 2021.CS1 održavanje: nepoznati jezik (link)
^ Iwabuchi KA, Yamakawa T, Sato Y, Ichisaka T, Takahashi K, Okita K, Yamanaka S (maj 2011). "ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the maintenance and induction of pluripotency". PLOS ONE. 6 (5): e20461. Bibcode:2011PLoSO...620461I. doi:10.1371/journal.pone.0020461. PMC 3102727. PMID 21637830.
^ Närvä E, Rahkonen N, Emani MR, Lund R, Pursiheimo JP, Nästi J, Autio R, Rasool O, Denessiouk K, Lähdesmäki H, Rao A, Lahesmaa R (mart 2012). "RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation". Stem Cells. 30 (3): 452–60. doi:10.1002/stem.1013. PMC 3507993. PMID 22162396.
^ Wong RC, Ibrahim A, Fong H, Thompson N, Lock LF, Donovan PJ (april 2011). "L1TD1 is a marker for undifferentiated human embryonic stem cells". PLOS ONE. 6 (4): e19355. Bibcode:2011PLoSO...619355W. doi:10.1371/journal.pone.0019355. PMC 3084827. PMID 21559406.
^ Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y (oktobar 2008). "LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis". Cancer Epidemiol Biomarkers Prev. 17 (10): 2555–64. doi:10.1158/1055-9965.EPI-08-0112. PMID 18842996.

Dopunska literatura[uredi | uredi izvor]

Mitsui K, Tokuzawa Y, Itoh H, et al. (2003). "The homeoprotein Nanog isrequired for maintenance of pluripotency in mouse epiblast and ES cells". Cell. 113 (5): 631–42. doi:10.1016/S0092-8674(03)00393-3. PMID 12787504. S2CID 18836242.
Cash HL, Tao L, Yuan JM, et al. (2012). "LINE-1 hypomethylation is associated with bladder cancer risk among nonsmoking Chinese". Int J Cancer. 130 (5): 1151–9. doi:10.1002/ijc.26098. PMC 3208798. PMID 21445976.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000240563 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[UniProt-3] "UniProt, Q5T7N2" (jezik: eng.). Pristupljeno 29. 11. 2021.CS1 održavanje: nepoznati jezik (link)

[pmid21637830-4] Iwabuchi KA, Yamakawa T, Sato Y, Ichisaka T, Takahashi K, Okita K, Yamanaka S (maj 2011). "ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the maintenance and induction of pluripotency". PLOS ONE. 6 (5): e20461. Bibcode:2011PLoSO...620461I. doi:10.1371/journal.pone.0020461. PMC 3102727. PMID 21637830.

[pmid22162396-5] Närvä E, Rahkonen N, Emani MR, Lund R, Pursiheimo JP, Nästi J, Autio R, Rasool O, Denessiouk K, Lähdesmäki H, Rao A, Lahesmaa R (mart 2012). "RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation". Stem Cells. 30 (3): 452–60. doi:10.1002/stem.1013. PMC 3507993. PMID 22162396.

[pmid21559406-6] Wong RC, Ibrahim A, Fong H, Thompson N, Lock LF, Donovan PJ (april 2011). "L1TD1 is a marker for undifferentiated human embryonic stem cells". PLOS ONE. 6 (4): e19355. Bibcode:2011PLoSO...619355W. doi:10.1371/journal.pone.0019355. PMC 3084827. PMID 21559406.

[pmid18842996-7] Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y (oktobar 2008). "LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis". Cancer Epidemiol Biomarkers Prev. 17 (10): 2555–64. doi:10.1158/1055-9965.EPI-08-0112. PMID 18842996.

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