LGI2
| LGI2 | |||||||||||||||||||||||||
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| Identifikatori | |||||||||||||||||||||||||
| Aliasi | LGI2 | ||||||||||||||||||||||||
| Vanjski ID-jevi | OMIM: 608301 MGI: 2180196 HomoloGene: 10048 GeneCards: LGI2 | ||||||||||||||||||||||||
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| Ortolozi | |||||||||||||||||||||||||
| Vrste | Čovjek | Miš | |||||||||||||||||||||||
| Entrez | |||||||||||||||||||||||||
| Ensembl | |||||||||||||||||||||||||
| UniProt | |||||||||||||||||||||||||
| RefSeq (mRNK) | |||||||||||||||||||||||||
| RefSeq (bjelančevina) | |||||||||||||||||||||||||
| Lokacija (UCSC) | Chr 4: 25 – 25.03 Mb | Chr 5: 52.69 – 52.72 Mb | |||||||||||||||||||||||
| PubMed pretraga | [3] | [4] | |||||||||||||||||||||||
| Wikipodaci | |||||||||||||||||||||||||
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Član 2 porodice leucinski bogatih ponavljanja LGI jest protein koji je kod ljudi kodiran genom LGI2 sa hromosoma 4.[5][6][7]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 545 aminokiselina, а molekulska težina 62.298 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MALRRGGCGA | LGLLLLLLGA | ACLIPRSAQV | RRLARCPATC | SCTKESIICV | ||||
| GSSWVPRIVP | GDISSLSLVN | GTFSEIKDRM | FSHLPSLQLL | LLNSNSFTII | ||||
| RDDAFAGLFH | LEYLFIEGNK | IETISRNAFR | GLRDLTHLSL | ANNHIKALPR | ||||
| DVFSDLDSLI | ELDLRGNKFE | CDCKAKWLYL | WLKMTNSTVS | DVLCIGPPEY | ||||
| QEKKLNDVTS | FDYECTTTDF | VVHQTLPYQS | VSVDTFNSKN | DVYVAIAQPS | ||||
| MENCMVLEWD | HIEMNFRSYD | NITGQSIVGC | KAILIDDQVF | VVVAQLFGGS | ||||
| HIYKYDESWT | KFVKFQDIEV | SRISKPNDIE | LFQIDDETFF | VIADSSKAGL | ||||
| STVYKWNSKG | FYSYQSLHEW | FRDTDAEFVD | IDGKSHLILS | SRSQVPIILQ | ||||
| WNKSSKKFVP | HGDIPNMEDV | LAVKSFRMQN | TLYLSLTRFI | GDSRVMRWNS | ||||
| KQFVEIQALP | SRGAMTLQPF | SFKDNHYLAL | GSDYTFSQIY | QWDKEKQLFK | ||||
| KFKEIYVQAP | RSFTAVSTDR | RDFFFASSFK | GKTKIFEHII | VDLSL |
Reference
[uredi | uredi izvor]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000153012 - Ensembl, maj 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039252 - Ensembl, maj 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Gu W, Wevers A, Schroder H, Grzeschik KH, Derst C, Brodtkorb E, de Vos R, Steinlein OK (maj 2002). "The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins". FEBS Lett. 519 (1–3): 71–6. doi:10.1016/S0014-5793(02)02713-8. PMID 12023020. S2CID 41639083.
- ↑ Gu W, Gibert Y, Wirth T, Elischer A, Bloch W, Meyer A, Steinlein OK, Begemann G (Oct 2005). "Using gene-history and expression analyses to assess the involvement of LGI genes in human disorders". Mol Biol Evol. 22 (11): 2209–16. doi:10.1093/molbev/msi214. PMID 16014869.
- ↑ "Entrez Gene: LGI2 leucine-rich repeat LGI family, member 2".
- ↑ "UniProt, Q8N0V4" (jezik: engleski). Pristupljeno 29. 10. 2021.
Dopunska literatura
[uredi | uredi izvor]- Staub E, Pérez-Tur J, Siebert R, et al. (2002). "The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders". Trends Biochem. Sci. 27 (9): 441–4. doi:10.1016/S0968-0004(02)02163-1. PMID 12217514.
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Res. 8 (4): 179–87. doi:10.1093/dnares/8.4.179. PMID 11572484.
- Scheel H, Tomiuk S, Hofmann K (2003). "A common protein interaction domain links two recently identified epilepsy genes". Hum. Mol. Genet. 11 (15): 1757–62. doi:10.1093/hmg/11.15.1757. PMID 12095917.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wang L, Zhu YF, Guo XJ, et al. (2006). "A two-dimensional electrophoresis reference map of human ovary". J. Mol. Med. 83 (10): 812–21. doi:10.1007/s00109-005-0676-y. PMID 16021519. S2CID 6644433.