LHX9

LHX9
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2DMQ
Identifikatori
Aliasi	LHX9
Vanjski ID-jevi	OMIM: 606066 MGI: 1316721 HomoloGene: 7816 GeneCards: LHX9
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	197,935,478 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	138,848,577 bp
Ontologija gena
Molekularna funkcija	• sequence-specific DNA binding; • vezivanje sa DNK; • GO:0001948, GO:0016582 vezivanje za proteine; • GO:0001106 transcription corepressor activity; • vezivanje iona metala; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • RNA polymerase II transcription regulatory region sequence-specific DNA binding;
Ćelijska komponenta	• jedro;
Biološki proces	• Ćelijska proliferacija; • male gonad development; • GO:0045996 negative regulation of transcription, DNA-templated; • GO:0009373 regulation of transcription, DNA-templated; • female gonad development; • gonad morphogenesis; • dorsal spinal cord interneuron anterior axon guidance; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • neuron differentiation; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	56956
	16876
	ENSG00000143355
	ENSMUSG00000019230
	Q9NQ69
	Q9WUH2
	NM_001014434; NM_020204; NM_001370213
	NM_001025565; NM_001042577; NM_010714
	NP_001014434; NP_064589; NP_001357142
	NP_001020736; NP_001036042; NP_034844
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

LIM-homeoboks 9 jest protein koji je kod ljudi kodiran genom LHX9 sa hromosoma 1.^[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 397 aminokiselina, a molekulska težina 43.976 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MEIVGCRAED	NSCPFRPPAM	LFHGISGGHI	QGIMEEMERR	SKTEARLAKG
AQLNGRDAGM	PPLSPEKPAL	CAGCGGKISD	RYYLLAVDKQ	WHLRCLKCCE
CKLALESELT	CFAKDGSIYC	KEDYYRRFSV	QRCARCHLGI	SASEMVMRAR
DSVYHLSCFT	CSTCNKTLTT	GDHFGMKDSL	VYCRAHFETL	LQGEYPPQLS
YTELAAKSGG	LALPYFNGTG	TVQKGRPRKR	KSPALGVDIV	NYNSGCNENE
ADHLDRDQQP	YPPSQKTKRM	RTSFKHHQLR	TMKSYFAINH	NPDAKDLKQL
AQKTGLTKRV	LQVWFQNARA	KFRRNLLRQE	NGGVDKADGT	SLPAPPSADS
GALTPPGTAT	TLTDLTNPTI	TVVTSVTSNM	DSHESGSPSQ	TTLTNLF

Funkcija[uredi | uredi izvor]

Ovaj gen kodira člana porodice gena LIM-homeoboksa razvojno eksprimiranih transkripcijskih faktoraa. Kodirani protein sadrži homeodomen i dva LIM-domena koji se vezuju za cistein, uključene u interakcije protein-protein. Protein je vrlo sličan proteinu miša koji uzrokuje agenezu gonada kada je inaktiviran, što ukazuje na ulogu u razvoju gonada. Alternativna prerada rezultira višestrukim varijantama transkripta.

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143355 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019230 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: LIM homeobox 9".
^ "UniProt, Q9NQ69" (jezik: engleski). Pristupljeno 13. 12. 2021.

Dopunska literatura[uredi | uredi izvor]

Avraham O, Hadas Y, Vald L, Zisman S, Schejter A, Visel A, Klar A (2009). "Transcriptional control of axonal guidance and sorting in dorsal interneurons by the Lim-HD proteins Lhx9 and Lhx1". Neural Dev. 4: 21. doi:10.1186/1749-8104-4-21. PMC 2704203. PMID 19545367.

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143355 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019230 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: LIM homeobox 9".

[UniProt-6] "UniProt, Q9NQ69" (jezik: engleski). Pristupljeno 13. 12. 2021.

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