LINGO2

LINGO2
Identifikatori
Aliasi	LINGO2
Vanjski ID-jevi	OMIM: 609793 MGI: 2442298 HomoloGene: 17621 GeneCards: LINGO2
Lokacija gena (čovjek)
Hrom.	Hromosom 9 (čovjek)
Kraj	28,670,286 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	36,951,747 bp
Ortolozi
	158038
	242384
	ENSG00000174482
	ENSMUSG00000045083
	Q7L985
	Q3URE9
	NM_001258282; NM_152570; NM_001354574; NM_001354575
	NM_001165999; NM_001166000; NM_001166001; NM_175516
	NP_001245211; NP_689783; NP_001341503; NP_001341504
	NP_001159471; NP_001159472; NP_001159473; NP_780725
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Leucinom bogato ponavljanje sa Ig domenom 2 je protein koji je kod ljudi kodiran genom LINGO2.^[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 606 aminokiselina, а molekulska težina 68.066 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MLHTAISCWQ	PFLGLAVVLI	FMGSTIGCPA	RCECSAQNKS	VSCHRRRLIA
IPEGIPIETK	ILDLSKNRLK	SVNPEEFISY	PLLEEIDLSD	NIIANVEPGA
FNNLFNLRSL	RLKGNRLKLV	PLGVFTGLSN	LTKLDISENK	IVILLDYMFQ
DLHNLKSLEV	GDNDLVYISH	RAFSGLLSLE	QLTLEKCNLT	AVPTEALSHL
RSLISLHLKH	LNINNMPVYA	FKRLFHLKHL	EIDYWPLLDM	MPANSLYGLN
LTSLSVTNTN	LSTVPFLAFK	HLVYLTHLNL	SYNPISTIEA	GMFSDLIRLQ
ELHIVGAQLR	TIEPHSFQGL	RFLRVLNVSQ	NLLETLEENV	FSSPRALEVL
SINNNPLACD	CRLLWILQRQ	PTLQFGGQQP	MCAGPDTIRE	RSFKDFHSTA
LSFYFTCKKP	KIREKKLQHL	LVDEGQTVQL	ECSADGDPQP	VISWVTPRRR
FITTKSNGRA	TVLGDGTLEI	RFAQDQDSGM	YVCIASNAAG	NDTFTASLTV
KGFASDRFLY	ANRTPMYMTD	SNDTISNGTN	ANTFSLDLKT	ILVSTAMGCF
TFLGVVLFCF	LLLFVWSRGK	GKHKNSIDLE	YVPRKNNGAV	VEGEVAGPRR
FNMKMI

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174482 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045083 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Leucine rich repeat and Ig domain containing 2". Pristupljeno 31. 3. 2014.
^ "UniProt, Q7L985". Pristupljeno 9. 9. 2021.

Dopunska literatura[uredi | uredi izvor]

Ferreira, R. C.; Pan-Hammarström, Q; Graham, R. R.; Gateva, V; Fontán, G; Lee, A. T.; Ortmann, W; Urcelay, E; Fernández-Arquero, M; Núñez, C; Jorgensen, G; Ludviksson, B. R.; Koskinen, S; Haimila, K; Clark, H. F.; Klareskog, L; Gregersen, P. K.; Behrens, T. W.; Hammarström, L (2010). "Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency". Nature Genetics. 42 (9): 777–80. doi:10.1038/ng.644. PMID 20694011. S2CID 205356843.
Wu, Y. W.; Prakash, K. M.; Rong, T. Y.; Li, H. H.; Xiao, Q; Tan, L. C.; Au, W. L.; Ding, J. Q.; Chen, S. D.; Tan, E. K. (2011). "Lingo2 variants associated with essential tremor and Parkinson's disease". Human Genetics. 129 (6): 611–5. doi:10.1007/s00439-011-0955-3. PMID 21287203. S2CID 23493765.
Su, F. C.; Chen, C. M.; Chen, Y. C.; Wu, Y. R. (2012). "LINGO-2 polymorphism and the risk of Parkinson's disease in Taiwan". Parkinsonism & Related Disorders. 18 (5): 609–11. doi:10.1016/j.parkreldis.2011.11.013. PMID 22123311.
Ichikawa, S; Koller, D. L.; Padgett, L. R.; Lai, D; Hui, S. L.; Peacock, M; Foroud, T; Econs, M. J. (2010). "Replication of previous genome-wide association studies of bone mineral density in premenopausal American women". Journal of Bone and Mineral Research. 25 (8): 1821–9. doi:10.1002/jbmr.62. PMC 3153352. PMID 20200978.
Vilariño-Güell, C; Wider, C; Ross, O. A.; Jasinska-Myga, B; Kachergus, J; Cobb, S. A.; Soto-Ortolaza, A. I.; Behrouz, B; Heckman, M. G.; Diehl, N. N.; Testa, C. M.; Wszolek, Z. K.; Uitti, R. J.; Jankovic, J; Louis, E. D.; Clark, L. N.; Rajput, A; Farrer, M. J. (2010). "LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease". Neurogenetics. 11 (4): 401–8. doi:10.1007/s10048-010-0241-x. PMC 3930084. PMID 20369371.
Carim-Todd, L; Escarceller, M; Estivill, X; Sumoy, L (2003). "LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex". The European Journal of Neuroscience. 18 (12): 3167–82. doi:10.1111/j.1460-9568.2003.03003.x. PMID 14686891. S2CID 42086715.
Speliotes, E. K.; Willer, C. J.; Berndt, S. I.; Monda, K. L.; Thorleifsson, G; Jackson, A. U.; Lango Allen, H; Lindgren, C. M.; Luan, J; Mägi, R; Randall, J. C.; Vedantam, S; Winkler, T. W.; Qi, L; Workalemahu, T; Heid, I. M.; Steinthorsdottir, V; Stringham, H. M.; Weedon, M. N.; Wheeler, E; Wood, A. R.; Ferreira, T; Weyant, R. J.; Segrè, A. V.; Estrada, K; Liang, L; Nemesh, J; Park, J. H.; Gustafsson, S; et al. (2010). "Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index". Nature Genetics. 42 (11): 937–48. doi:10.1038/ng.686. PMC 3014648. PMID 20935630.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174482 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045083 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Leucine rich repeat and Ig domain containing 2". Pristupljeno 31. 3. 2014.

[UniProt-6] "UniProt, Q7L985". Pristupljeno 9. 9. 2021.

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