LOC642658

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LOC642658
Identifikatori
AliasiSCX
Vanjski ID-jeviOMIM: 609067 MGI: 102934 HomoloGene: 85195 GeneCards: SCX
Lokacija gena (čovjek)
Hromosom 8 (čovjek)
Hrom.Hromosom 8 (čovjek)[1]
Hromosom 8 (čovjek)
Genomska lokacija za LOC642658
Genomska lokacija za LOC642658
Bend8q24.3Početak144,266,453 bp[1]
Kraj144,268,481 bp[1]
Lokacija gena (miš)
Hromosom 15 (miš)
Hrom.Hromosom 15 (miš)[2]
Hromosom 15 (miš)
Genomska lokacija za LOC642658
Genomska lokacija za LOC642658
Bend15 D3|15 35.92 cMPočetak76,341,652 bp[2]
Kraj76,343,658 bp[2]
Ontologija gena
Molekularna funkcija GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
DNA binding
sequence-specific DNA binding
protein dimerization activity
bHLH transcription factor binding
E-box binding
GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific
protein heterodimerization activity
GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
Ćelijska komponenta transcription regulator complex
Jedro
Biološki proces cellular response to transforming growth factor beta stimulus
positive regulation of collagen biosynthetic process
Ćelijska diferencijacija
GO:0009373 regulation of transcription, DNA-templated
chondrocyte differentiation
regulation of cartilage development
positive regulation of gastrulation
collagen fibril organization
tendon development
tendon cell differentiation
mesoderm formation
cellular response to BMP stimulus
negative regulation of apoptotic process
Sertoli cell differentiation
endochondral ossification
transcription by RNA polymerase II
BMP signaling pathway
transcription, DNA-templated
sclerotome development
embryonic skeletal system development
GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
multicellular organism development
deltoid tuberosity development
cellular response to mechanical stimulus
GO:1901313 positive regulation of gene expression
heart valve formation
positive regulation of cartilage development
heart valve morphogenesis
tissue homeostasis
positive regulation of cell population proliferation
tendon formation
skeletal muscle cell differentiation
GO:0045996 negative regulation of transcription, DNA-templated
face morphogenesis
GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001008271
NM_001080514

NM_198885

RefSeq (bjelančevina)

NP_001073983

NP_942588

Lokacija (UCSC)Chr 8: 144.27 – 144.27 MbChr 15: 76.34 – 76.34 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Osnovni skleraksni transkripcijski faktor heliks-petlja-heliks je protein koji je kod ljudi kodiran genom SCXB.[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 201 aminokiselina, а molekulska težina 21.596 Da.[6]

1020304050
MSFATLRPAPPGRYLYPEVSPLSEDEDRGSDSSGSDEKPCRVHAARCGLQ
GARRRAGGRRAGGGGPGGRPGREPRQRHTANARERDRTNSVNTAFTALRT
LIPTEPADRKLSKIETLRLASSYISHLGNVLLAGEACGDGQPCHSGPAFF
HAARAGSPPPPPPPPPARDGENTQPKQICTFCLSNQRKLSKDRDRKTAIR
S

Reference[uredi | uredi izvor]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000260428 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034161 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: LOC642658 similar to Basic helix-loop-helix transcription factor scleraxis".
  6. ^ "UniProt, Q7RTU7" (jezik: engleski). Pristupljeno 19. 9. 2021.