LPCAT1

LPCAT1
Identifikatori
Aliasi	LPCAT1
Vanjski ID-jevi	OMIM: 610472 MGI: 2384812 HomoloGene: 9871 GeneCards: LPCAT1
EC broj	2.3.1.67
Lokacija gena (čovjek)
Hrom.	Hromosom 5 (čovjek)
Kraj	1,523,962 bp
Lokacija gena (miš)
Hrom.	Hromosom 13 (miš)
Kraj	73,664,541 bp
Ontologija gena
Molekularna funkcija	• 1-alkylglycerophosphocholine O-acyltransferase activity; • vezivanje iona metala; • calcium ion binding; • transferase activity; • acyltransferase activity; • 1-alkylglycerophosphocholine O-acetyltransferase activity; • 1-alkenylglycerophosphocholine O-acyltransferase activity; • 1-acylglycerophosphocholine O-acyltransferase activity; • 1-acylglycerol-3-phosphate O-acyltransferase activity; • 2-acylglycerol-3-phosphate O-acyltransferase activity;
Ćelijska komponenta	• integral component of membrane; • Golđijev aparat; • Golđijeva membrana; • membrana; • Lipidna kapljica; • endoplasmic reticulum membrane; • Endoplazmatski retikulum; • ćelijska membrana; • azurophil granule membrane;
Biološki proces	• phospholipid biosynthetic process; • retina development in camera-type eye; • lipid metabolism; • phosphatidylglycerol acyl-chain remodeling; • GO:1903364 positive regulation of protein catabolic process; • phosphatidic acid biosynthetic process; • metabolizam; • surfactant homeostasis; • negative regulation of phosphatidylcholine biosynthetic process; • phosphatidylcholine acyl-chain remodeling; • phospholipid metabolic process; • phosphatidylcholine biosynthetic process; • neutrophil degranulation;
	Izvori:Amigo / QuickGO
Ortolozi
	79888
	210992
	ENSG00000275079; ENSG00000153395
	ENSMUSG00000021608
	Q8NF37
	Q3TFD2
	NM_024830
	NM_145376; NM_001368681; NM_001368682
	NP_079106
	NP_663351; NP_001355610; NP_001355611
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Lizofosfatidilholin-aciltransferaza 1 jest protein/enzim koji je kod ljudi kodiran genom LPCAT1 sa hromosoma 5.^[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je aminokiselina, а molekulska težina 59.151 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MRLRGCGPRA	APASSAGASD	ARLLAPPGRN	PFVHELRLSA	LQKAQVALMT
LTLFPVRLLV	AAAMMLLAWP	LALVASLGSA	EKEPEQPPAL	WRKVVDFLLK
AIMRTMWFAG	GFHRVAVKGR	QALPTEAAIL	TLAPHSSYFD	AIPVTMTMSS
IVMKAESRDI	PIWGTLIQYI	RPVFVSRSDQ	DSRRKTVEEI	KRRAQSNGKW
PQIMIFPEGT	CTNRTCLITF	KPGAFIPGAP	VQPVVLRYPN	KLDTITWTWQ
GPGALEILWL	TLCQFHNQVE	IEFLPVYSPS	EEEKRNPALY	ASNVRRVMAE
ALGVSVTDYT	FEDCQLALAE	GQLRLPADTC	LLEFARLVRG	LGLKPEKLEK
DLDRYSERAR	MKGGEKIGIA	EFAASLEVPV	SDLLEDMFSL	FDESGSGEVD
LRECVVALSV	VCRPARTLDT	IQLAFKMYGA	QEDGSVGEGD	LSCILKTALG
VAELTVTDLF	RAIDQEEKGK	ITFADFHRFA	EMYPAFAEEY	LYPDQTHFES
CAETSPAPIP	NGFCADFSPE	NSDAGRKPVR	KKLD

Funkcija[uredi | uredi izvor]

Lizofosfatidilholin (LPC) aciltransferaza (LPCAT; EC 2.3.1.23) katalizira pretvorbu LPC u fosfatidilholin (PC) na putu remodeliranja biosinteze PC-a.^[7]

Reference[uredi | uredi izvor]

^ ^a ^b ^c ENSG00000153395 GRCh38: Ensembl release 89: ENSG00000275079, ENSG00000153395 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021608 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Lysophosphatidylcholine acyltransferase 1".
^ "UniProt, Q8NF37" (jezik: engleski). Pristupljeno 16. 10. 2021.
^ Nakanishi H, Shindou H, Hishikawa D, Harayama T, Ogasawara R, Suwabe A, Taguchi R, Shimizu T (2006). "Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production". J. Biol. Chem. 281 (29): 20140–7. doi:10.1074/jbc.M600225200. PMID 16704971.

Vanjski linkovi[uredi | uredi izvor]

Šablon:PAF signalizacija

[refGRCh38Ensembl-1] ENSG00000153395 GRCh38: Ensembl release 89: ENSG00000275079, ENSG00000153395 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021608 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Lysophosphatidylcholine acyltransferase 1".

[UniProt-6] "UniProt, Q8NF37" (jezik: engleski). Pristupljeno 16. 10. 2021.

[pmid16704971-7] Nakanishi H, Shindou H, Hishikawa D, Harayama T, Ogasawara R, Suwabe A, Taguchi R, Shimizu T (2006). "Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production". J. Biol. Chem. 281 (29): 20140–7. doi:10.1074/jbc.M600225200. PMID 16704971.

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p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak