LYAR
Jedarcetov protein regulacije ćelijskog rasta jest protein koji je kod ljudi kodiran genom LYAR sa hromosoma 4 (reaktivni klonski antigen Ly-1).[5]
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 379 aminokiselina, а molekulska težina 43.615 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MVFFTCNACG | ESVKKIQVEK | HVSVCRNCEC | LSCIDCGKDF | WGDDYKNHVK | ||||
| CISEDQKYGG | KGYEGKTHKG | DIKQQAWIQK | ISELIKRPNV | SPKVRELLEQ | ||||
| ISAFDNVPRK | KAKFQNWMKN | SLKVHNESIL | DQVWNIFSEA | SNSEPVNKEQ | ||||
| DQRPLHPVAN | PHAEISTKVP | ASKVKDAVEQ | QGEVKKNKRE | RKEERQKKRK | ||||
| REKKELKLEN | HQENSRNQKP | KKRKKGQEAD | LEAGGEEVPE | ANGSAGKRSK | ||||
| KKKQRKDSAS | EEEAHVGAGK | RKRRHSEVET | DSKKKKMKLP | EHPEGGEPED | ||||
| DEAPAKGKFN | WKGTIKAILK | QAPDNEITIK | KLRKKVLAQY | YTVTDEHHRS | ||||
| EEELLVIFNK | KISKNPTFKL | LKDKVKLVK |
Funkcija[uredi | uredi izvor]
LYAR sadrži motiv cinkovog prsta i tri kopije nukleolusnih signala. LYAR se uglavnom nalazi na jedarcima, u visokim nivoima u ranim embrionima i prvenstveno u jetri i fetusnom timusu.[7]
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000145220 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067367 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: LYAR hypothetical protein FLJ20425".
- ^ "UniProt, Q9NX58" (jezik: engleski). Pristupljeno 30. 10. 2021.
- ^ Su L, Hershberger RJ, Weissman IL (maj 1993). "LYAR, a novel nucleolar protein with zinc finger DNA-binding motifs, is involved in cell growth regulation". Genes Dev. 7 (5): 735–48. doi:10.1101/gad.7.5.735. PMID 8491376.
Dopunska literatura[uredi | uredi izvor]
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- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
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- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.