MAML3
Upravljački protein 3 (Drosophila) je protein koji je kod ljudi kodiran genom MAML3 sa hromosoma 4.[5]
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 1.138 aminokiselina, a molekulska težina 122.293 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MGDFAAPAAA | ANGSSICINS | SLNSSLGGAG | IGVNNTPNST | PAAPSSNHPA | ||||
| AGGCGGSGGP | GGGSAAVPKH | STVVERLRQR | IEGCRRHHVN | CENRYQQAQV | ||||
| EQLELERRDT | VSLYQRTLEQ | RAKKSGAGTG | KQQHPSKPQQ | DAEAASAEQR | ||||
| NHTLIMLQET | VKRKLEGARS | PLNGDQQNGA | CDGNFSPTSK | RIRKDISAGM | ||||
| EAINNLPSNM | PLPSASPLHQ | LDLKPSLPLQ | NSGTHTPGLL | EDLSKNGRLP | ||||
| EIKLPVNGCS | DLEDSFTILQ | SKDLKQEPLD | DPTCIDTSET | SLSNQNKLFS | ||||
| DINLNDQEWQ | ELIDELANTV | PEDDIQDLFN | EDFEEKKEPE | FSQPATETPL | ||||
| SQESASVKSD | PSHSPFAHVS | MGSPQARPSS | SGPPFSTVST | ATSLPSVAST | ||||
| PAAPNPASSP | ANCAVQSPQT | PNQAHTPGQA | PPRPGNGYLL | NPAAVTVAGS | ||||
| ASGPVAVPSS | DMSPAEQLKQ | MAAQQQQRAK | LMQQKQQQQQ | QQQQQQQQQQ | ||||
| QQQQQQQQQQ | HSNQTSNWSP | LGPPSSPYGA | AFTAEKPNSP | MMYPQAFNNQ | ||||
| NPIVPPMANN | LQKTTMNNYL | PQNHMNMINQ | QPNNLGTNSL | NKQHNILTYG | ||||
| NTKPLTHFNA | DLSQRMTPPV | ANPNKNPLMP | YIQQQQQQQQ | QQQQQQQQQQ | ||||
| PPPPQLQAPR | AHLSEDQKRL | LLMKQKGVMN | QPMAYAALPS | HGQEQHPVGL | ||||
| PRTTGPMQSS | VPPGSGGMVS | GASPAGPGFL | GSQPQAAIMK | QMLIDQRAQL | ||||
| IEQQKQQFLR | EQRQQQQQQQ | QQILAEQQLQ | QSHLPRQHLQ | PQRNPYPVQQ | ||||
| VNQFQGSPQD | IAAVRSQAAL | QSMRTSRLMA | QNAGMMGIGP | SQNPGTMATA | ||||
| AAQSEMGLAP | YSTTPTSQPG | MYNMSTGMTQ | MLQHPNQSGM | SITHNQAQGP | ||||
| RQPASGQGVG | MVSGFGQSML | VNSAITQQHP | QMKGPVGQAL | PRPQAPPRLQ | ||||
| SLMGTVQQGA | QSWQQRSLQG | MPGRTSGELG | PFNNGASYPL | QAGQPRLTKQ | ||||
| HFPQGLSQSV | VDANTGTVRT | LNPAAMGRQM | MPSLPGQQGT | SQARPMVMSG | ||||
| LSQGVPGMPA | FSQPPAQQQI | PSGSFAPSSQ | SQAYERNAPQ | DVSYNYSGDG | ||||
| AGGSFPGLPD | GADLVDSIIK | GGPGDEWMQE | LDELFGNP |
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000196782 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061143 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Mastermind-like 3 (Drosophila)".
- ^ "UniProt, Q96JK9" (jezik: engleski). Pristupljeno 29. 10. 2021.
Dopunska literatura[uredi | uredi izvor]
- Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (juli 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Human Genetics. 100 (1): 114–22. doi:10.1007/s004390050476. PMID 9225980. S2CID 25999127.
- Lin SE, Oyama T, Nagase T, Harigaya K, Kitagawa M (decembar 2002). "Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling". The Journal of Biological Chemistry. 277 (52): 50612–20. doi:10.1074/jbc.M209529200. PMID 12386158.
- Hu Z, Shi Y, Mo X, Xu J, Zhao B, Lin Y, Yang S, Xu Z, Dai J, Pan S, Da M, Wang X, Qian B, Wen Y, Wen J, Xing J, Guo X, Xia Y, Ma H, Jin G, Yu S, Liu J, Zhou Z, Wang X, Chen Y, Sha J, Shen H (juli 2013). "A genome-wide association study identifies two risk loci for congenital heart malformations in Han Chinese populations". Nature Genetics. 45 (7): 818–21. doi:10.1038/ng.2636. PMID 23708190. S2CID 7904277.
- Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ (februar 2003). "t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway". Nature Genetics. 33 (2): 208–13. doi:10.1038/ng1083. PMID 12539049. S2CID 23417795.
- Wu L, Sun T, Kobayashi K, Gao P, Griffin JD (novembar 2002). "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors". Molecular and Cellular Biology. 22 (21): 7688–700. doi:10.1128/MCB.22.21.7688-7700.2002. PMC 135662. PMID 12370315.