MAN1A1

MAN1A1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1NXC
Identifikatori
Aliasi	MAN1A1
Vanjski ID-jevi	OMIM: 604344 MGI: 104677 HomoloGene: 4316 GeneCards: MAN1A1
Lokacija gena (čovjek) Hrom. Hromosom 6 (čovjek) Bend 6q22.31 Početak 119,177,205 bp Kraj 119,349,761 bp
Lokacija gena (miš) Hrom. Hromosom 10 (miš) Bend 10|10 B3 Početak 53,780,881 bp Kraj 53,952,705 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • calcium ion binding • hydrolase activity • mannosidase activity • hydrolase activity, acting on glycosyl bonds • mannosyl-oligosaccharide 1,2-alpha-mannosidase activity • catalytic activity Ćelijska komponenta • integral component of membrane • Golđijeva membrana • Golđijev aparat • Egzosom • Endoplazmatski retikulum • membrana • endoplasmic reticulum-Golgi intermediate compartment • citosol Biološki proces • GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation • N-glycan processing • metabolizam • Golgi apparatus mannose trimming Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	4121	17155
Ensembl	ENSG00000111885	ENSMUSG00000003746
UniProt	P33908	P45700
RefSeq (mRNK)	NM_005907	NM_008548
RefSeq (bjelančevina)	NP_005898	NP_032574
Lokacija (UCSC)	Chr 6: 119.18 – 119.35 Mb	Chr 10: 53.78 – 53.95 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Manozil-oligosaharid 1,2-alfa-mannozidaza IA jest enzim koji je kod ljudi kodiran genom MAN1A1.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 653 aminokiseline, а molekulska težina 72.969 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MPVGGLLPLF		SSPAGGVLGG		GLGGGGGRKG		SGPAALRLTE		KFVLLLVFSA
FITLCFGAIF		FLPDSSKLLS		GVLFHSSPAL		QPAADHKPGP		GARAEDAAEG
RARRREEGAP		GDPEAALEDN		LARIRENHER		ALREAKETLQ		KLPEEIQRDI
LLEKKKVAQD		QLRDKAPFRG		LPPVDFVPPI		GVESREPADA		AIREKRAKIK
EMMKHAWNNY		KGYAWGLNEL		KPISKGGHSS		SLFGNIKGAT		IVDALDTLFI
MEMKHEFEEA		KSWVEENLDF		NVNAEISVFE		VNIRFVGGLL		SAYYLSGEEI
FRKKAVELGV		KLLPAFHTPS		GIPWALLNMK		SGIGRNWPWA		SGGSSILAEF
GTLHLEFMHL		SHLSGNPIFA		EKVMNIRTVL		NKLEKPQGLY		PNYLNPSSGQ
WGQHHVSVGG		LGDSFYEYLL		KAWLMSDKTD		LEAKKMYFDA		VQAIETHLIR
KSSSGLTYIA		EWKGGLLEHK		MGHLTCFAGG		MFALGADAAP		EGMAQHYLEL
GAEIARTCHE		SYNRTFMKLG		PEAFRFDGGV		EAIATRQNEK		YYILRPEVME
TYMYMWRLTH		DPKYRKWAWE		AVEALENHCR		VNGGYSGLRD		VYLLHESYDD
VQQSFFLAET		LKYLYLIFSD		DDLLPLEHWI		FNSEAHLLPI		LPKDKKEVEI
REE

Funkcija

Ovaj gen kodira sisarsku Golgijevu 1,2-manozidazu klase I, koja je transmembranski protein tipa II. Ovaj protein katalizira uklanjanje tri različita ostatka manoze iz peptid-vezanih Man (9) -GlcNAc (2) oligosaharida i pripada porodici 47 glikozil hidrolaza.

Dopunska literatura

• Land A, Braakman I (2001). "Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum". Biochimie. 83 (8): 783–90. doi:10.1016/S0300-9084(01)01314-1. hdl:1874/5091. PMID 11530211.
• Dedera DA, Gu RL, Ratner L (1992). "Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function". Virology. 187 (1): 377–82. doi:10.1016/0042-6822(92)90331-I. PMID 1736542.
• Kalyanaraman VS, Rodriguez V, Veronese F, et al. (1990). "Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1". AIDS Res. Hum. Retroviruses. 6 (3): 371–80. doi:10.1089/aid.1990.6.371. PMID 2187500.
• Shimizu H, Tsuchie H, Honma H, et al. (1991). "Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins". Jpn. J. Med. Sci. Biol. 43 (3): 75–87. doi:10.7883/yoken1952.43.75. PMID 2283726.
• Leonard CK, Spellman MW, Riddle L, et al. (1990). "Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells". J. Biol. Chem. 265 (18): 10373–82. doi:10.1016/S0021-9258(18)86956-3. PMID 2355006.
• Stein BS, Engleman EG (1990). "Intracellular processing of the gp160 HIV-1 envelope precursor. Endoproteolytic cleavage occurs in a cis or medial compartment of the Golgi complex". J. Biol. Chem. 265 (5): 2640–9. doi:10.1016/S0021-9258(19)39849-7. PMID 2406237.
• Pal R, Hoke GM, Sarngadharan MG (1989). "Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 86 (9): 3384–8. Bibcode:1989PNAS...86.3384P. doi:10.1073/pnas.86.9.3384. PMC 287137. PMID 2541446.
• Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP (1989). "Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport". J. Virol. 63 (6): 2452–6. doi:10.1128/JVI.63.6.2452-2456.1989. PMC 250699. PMID 2542563.
• Kozarsky K, Penman M, Basiripour L, et al. (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein". J. Acquir. Immune Defic. Syndr. 2 (2): 163–9. PMID 2649653.
• Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis". AIDS Res. Hum. Retroviruses. 3 (3): 265–82. doi:10.1089/aid.1987.3.265. PMID 2829950.
• Blough HA, Pauwels R, De Clercq E, et al. (1987). "Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins". Biochem. Biophys. Res. Commun. 141 (1): 33–8. doi:10.1016/S0006-291X(86)80330-8. PMID 3099781.
• Montefiori DC, Robinson WE, Mitchell WM (1988). "Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 85 (23): 9248–52. Bibcode:1988PNAS...85.9248M. doi:10.1073/pnas.85.23.9248. PMC 282716. PMID 3264072.
• Bieberich E, Bause E (1995). "Man9-mannosidase from human kidney is expressed in COS cells as a Golgi-resident type II transmembrane N-glycoprotein". Eur. J. Biochem. 233 (2): 644–9. doi:10.1111/j.1432-1033.1995.644_2.x. PMID 7588811.
• Fenouillet E, Jones I, Powell B, et al. (1993). "Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. doi:10.1128/JVI.67.1.150-160.1993. PMC 237347. PMID 8093218.
• Yeh JC, Seals JR, Murphy CI, et al. (1993). "Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system". Biochemistry. 32 (41): 11087–99. doi:10.1021/bi00092a019. PMID 8218172.
• Bolmstedt A, Sjölander S, Hansen JE, et al. (1996). "Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (3): 213–20. doi:10.1097/00042560-199607000-00001. PMID 8673525.
• Hu H, Shioda T, Moriya C, et al. (1996). "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface". J. Virol. 70 (11): 7462–70. doi:10.1128/JVI.70.11.7462-7470.1996. PMC 190813. PMID 8892864.
• Papandreou MJ, Fenouillet E (1997). "Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation". FEBS Lett. 406 (1–2): 191–5. doi:10.1016/S0014-5793(97)00273-1. PMID 9109416. S2CID 17660.
• Bieberich E, Treml K, Völker C, et al. (1997). "Man9-mannosidase from pig liver is a type-II membrane protein that resides in the endoplasmic reticulum. cDNA cloning and expression of the enzyme in COS 1 cells". Eur. J. Biochem. 246 (3): 681–9. doi:10.1111/j.1432-1033.1997.t01-1-00681.x. PMID 9219526.