MAN1A2

MAN1A2
Identifikatori
Aliasi	MAN1A2
Vanjski ID-jevi	OMIM: 604345 MGI: 104676 HomoloGene: 55982 GeneCards: MAN1A2
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	117,528,872 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	100,592,819 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• calcium ion binding; • hydrolase activity; • hydrolase activity, acting on glycosyl bonds; • vezivanje iona metala; • mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; • catalytic activity;
Ćelijska komponenta	• Golđijev aparat; • Egzosom; • Endoplazmatski retikulum; • membrana; • integral component of membrane; • Golđijeva membrana;
Biološki proces	• GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation; • N-glycan processing; • lung alveolus development; • metabolizam; • glycoprotein metabolic process; • Golgi apparatus mannose trimming; • respiratory gaseous exchange by respiratory system;
	Izvori:Amigo / QuickGO
Ortolozi
	10905
	17156
	ENSG00000198162
	ENSMUSG00000008763
	O60476
	P39098
	NM_006699
	NM_010763
	NP_006690
	NP_034893
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Mannozil-oligosaharidna 1,2-alfa-manozidaza IB jest enzim koji je kod ljudi kodiran genom MAN1A2 sa hromosoma 1.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 641 aminokiselina, a molekulska težina 73.004 Da. ^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MTTPALLPLS	GRRIPPLNLG	PPSFPHHRAT	LRLSEKFILL	LILSAFITLC
FGAFFFLPDS	SKHKRFDLGL	EDVLIPHVDA	GKGAKNPGVF	LIHGPDEHRH
REEEERLRNK	IRADHEKALE	EAKEKLRKSR	EEIRAEIQTE	KNKVVQEMKI
KENKPLPPVP	IPNLVGIRGG	DPEDNDIREK	REKIKEMMKH	AWDNYRTYGW
GHNELRPIAR	KGHSPNIFGS	SQMGATIVDA	LDTLYIMGLH	DEFLDGQRWI
EDNLDFSVNS	EVSVFEVNIR	FIGGLLAAYY	LSGEEIFKIK	AVQLAEKLLP
AFNTPTGIPW	AMVNLKSGVG	RNWGWASAGS	SILAEFGTLH	MEFIHLSYLT
GDLTYYKKVM	HIRKLLQKMD	RPNGLYPNYL	NPRTGRWGQY	HTSVGGLGDS
FYEYLLKAWL	MSDKTDHEAR	KMYDDAIEAI	EKHLIKKSRG	GLTFIGEWKN
GHLEKKMGHL	ACFAGGMFAL	GADGSRADKA	GHYLELGAEI	ARTCHESYDR
TALKLGPESF	KFDGAVEAVA	VRQAEKYYIL	RPEVIETYWY	LWRFTHDPRY
RQWGWEAALA	IEKYCRVNGG	FSGVKDVYSS	TPTHDDVQQS	FFLAETLKYL
YLLFSGDDLL	PLDHWVFNTE	AHPLPVLHLA	NTTLSGNPAV	R

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198162 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000008763 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tremblay LO, Campbell Dyke N, Herscovics A (Jul 1998). "Molecular cloning, chromosomal mapping and tissue-specific expression of a novel human alpha1,2-mannosidase gene involved in N-glycan maturation". Glycobiology. 8 (6): 585–595. doi:10.1093/glycob/8.6.585. PMID 9592125.
^ "Entrez Gene: MAN1A2 mannosidase, alpha, class 1A, member 2".
^ "UniProt, O60476" (jezik: eng.). Pristupljeno 30. 11. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura[uredi | uredi izvor]

Land A, Braakman I (2001). "Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum". Biochimie. 83 (8): 783–790. doi:10.1016/S0300-9084(01)01314-1. hdl:1874/5091. PMID 11530211.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–321. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–1332. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Hart ML, Saifuddin M, Spear GT (2003). "Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin". J. Gen. Virol. 84 (Pt 2): 353–360. doi:10.1099/vir.0.18734-0. PMID 12560567.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Papandreou MJ, Fenouillet E (1997). "Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation". FEBS Lett. 406 (1–2): 191–195. doi:10.1016/S0014-5793(97)00273-1. PMID 9109416. S2CID 17660.
Hu H, Shioda T, Moriya C, et al. (1996). "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface". J. Virol. 70 (11): 7462–7470. doi:10.1128/jvi.70.11.7462-7470.1996. PMC 190813. PMID 8892864.
Bolmstedt A, Sjölander S, Hansen JE, et al. (1996). "Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (3): 213–220. doi:10.1097/00042560-199607000-00001. PMID 8673525.
Yeh JC, Seals JR, Murphy CI, et al. (1993). "Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system". Biochemistry. 32 (41): 11087–11099. doi:10.1021/bi00092a019. PMID 8218172.
Fenouillet E, Jones I, Powell B, et al. (1993). "Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–160. doi:10.1128/jvi.67.1.150-160.1993. PMC 237347. PMID 8093218.
Montefiori DC, Robinson WE, Mitchell WM (1988). "Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 85 (23): 9248–9252. Bibcode:1988PNAS...85.9248M. doi:10.1073/pnas.85.23.9248. PMC 282716. PMID 3264072.
Blough HA, Pauwels R, De Clercq E, et al. (1987). "Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins". Biochem. Biophys. Res. Commun. 141 (1): 33–38. doi:10.1016/S0006-291X(86)80330-8. PMID 3099781.
Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis". AIDS Res. Hum. Retroviruses. 3 (3): 265–282. doi:10.1089/aid.1987.3.265. PMID 2829950.
Kozarsky K, Penman M, Basiripour L, et al. (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein". J. Acquir. Immune Defic. Syndr. 2 (2): 163–169. PMID 2649653.
Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP (1989). "Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport". J. Virol. 63 (6): 2452–2456. doi:10.1128/jvi.63.6.2452-2456.1989. PMC 250699. PMID 2542563.

Vanjski linkovi[uredi | uredi izvor]

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198162 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000008763 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9592125-5] Tremblay LO, Campbell Dyke N, Herscovics A (Jul 1998). "Molecular cloning, chromosomal mapping and tissue-specific expression of a novel human alpha1,2-mannosidase gene involved in N-glycan maturation". Glycobiology. 8 (6): 585–595. doi:10.1093/glycob/8.6.585. PMID 9592125.

[entrez-6] "Entrez Gene: MAN1A2 mannosidase, alpha, class 1A, member 2".

[UniProt-7] "UniProt, O60476" (jezik: eng.). Pristupljeno 30. 11. 2021.CS1 održavanje: nepoznati jezik (link)

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p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak