MBOAT5
Lizofosfolipid-aciltransferaza 5 je enzim koji je kod ljudi kodiran genom LPCAT3.[5][6][7][8]
Homologan je sa drugim O-aciltransferazama vezanim za membranu.
Pregled[uredi | uredi izvor]
Ljudski hromosom 12 sadrži više od 1.400 kodirajućih gena i 487 lokusa koji su direktno uključeni u ljudske bolese. Dugi (q) krak hromooma 12 sadrži jedan od najvećih blokova neravnoteže povezivanja koji se nalazi u ljudskom genomu. Gotova sekvencu ljudskog hromosoma 12, koja je dovršena do visokog kvaliteta i obuhvata približno 132 megabaze, što predstavlja približno 4,5% ljudskog genoma. Poravnavanje sekvence ljudskog hromosoma 12 sa kičmenjacima otkriva porijeklo pojedinačnih segmenata kod kokoši i jedinstvenu historiju preuređivanja putem loza glodara i primata. Stopa zamjena nukleotida u novijoj evolucijskoj povijesti pokazuje opće usporavanje u hominida u odnosu na primate i glodare.
Nakon završetka nacrta sekvence ljudsog genoma, Međunarodni konzorcij za sekvenciranje ljudskog genoma nastavio je s dovršavanjem i označavanjem svakog od 23 hromosoma koji čine ljudski genom.
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 487 aminokiselina, a molekulska težina 56.035 Da.[9]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MASSAEGDEG | TVVALAGVLQ | SGFQELSLNK | LATSLGASEQ | ALRLIISIFL | ||||
| GYPFALFYRH | YLFYKETYLI | HLFHTFTGLS | IAYFNFGNQL | YHSLLCIVLQ | ||||
| FLILRLMGRT | ITAVLTTFCF | QMAYLLAGYY | YTATGNYDIK | WTMPHCVLTL | ||||
| KLIGLAVDYF | DGGKDQNSLS | SEQQKYAIRG | VPSLLEVAGF | SYFYGAFLVG | ||||
| PQFSMNHYMK | LVQGELIDIP | GKIPNSIIPA | LKRLSLGLFY | LVGYTLLSPH | ||||
| ITEDYLLTED | YDNHPFWFRC | MYMLIWGKFV | LYKYVTCWLV | TEGVCILTGL | ||||
| GFNGFEEKGK | AKWDACANMK | VWLFETNPRF | TGTIASFNIN | TNAWVARYIF | ||||
| KRLKFLGNKE | LSQGLSLLFL | ALWHGLHSGY | LVCFQMEFLI | VIVERQAARL | ||||
| IQESPTLSKL | AAITVLQPFY | YLVQQTIHWL | FMGYSMTAFC | LFTWDKWLKV | ||||
| YKSIYFLGHI | FFLSLLFILP | YIHKAMVPRK | EKLKKME |
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000111684 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004270 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Ansari-Lari MA, Muzny DM, Lu J, Lu F, Lilley CE, Spanos S, Malley T, Gibbs RA (Sep 1996). "A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13". Genome Res. 6 (4): 314–26. doi:10.1101/gr.6.4.314. PMID 8723724.
- ^ Ansari-Lari MA, Shen Y, Muzny DM, Lee W, Gibbs RA (maj 1997). "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination". Genome Res. 7 (3): 268–80. doi:10.1101/gr.7.3.268. PMID 9074930.
- ^ Zhao Y, Chen YQ, Bonacci TM, Bredt DS, Li S, Bensch WR, Moller DE, Kowala M, Konrad RJ, Cao G (Mar 2008). "Identification and characterization of a major liver lysophosphatidylcholine acyltransferase". J Biol Chem. 283 (13): 8258–65. doi:10.1074/jbc.M710422200. PMID 18195019.
- ^ "Entrez Gene: MBOAT5 membrane bound O-acyltransferase domain containing 5".
- ^ "UniProt, Q6P1A2". Pristupljeno 11. 8. 2021.
Dopunska literatura[uredi | uredi izvor]
- Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12". Nature. 440 (7082): 346–51. doi:10.1038/nature04569. PMID 16541075.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Maurel-Zaffran C, Chauvet S, Jullien N, et al. (1999). "nessy, an evolutionary conserved gene controlled by Hox proteins during Drosophila embryogenesis". Mech. Dev. 86 (1–2): 159–63. doi:10.1016/S0925-4773(99)00105-7. PMID 10446276. S2CID 5793636.
Vanjski linkovi[uredi | uredi izvor]
- LPCAT3 lokacija ljudskog genoma UCSC Genome Browser.
- Šablon:UCSC gen details