MEAF6

MEAF6
Identifikatori
Aliasi	MEAF6
Vanjski ID-jevi	OMIM: 611001 MGI: 1917338 HomoloGene: 11240 GeneCards: MEAF6
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	37,514,766 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	125,007,031 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • histone acetyltransferase activity (H3-K23 specific);
Ćelijska komponenta	• NuA4 histone acetyltransferase complex; • MOZ/MORF histone acetyltransferase complex; • histone acetyltransferase complex; • jedro; • Jedarce; • hromosom; • kinetohor; • Primarno suženje; • nukleoplazma; • NuA3a histone acetyltransferase complex; • NuA3b histone acetyltransferase complex;
Biološki proces	• histone H4-K12 acetylation; • GO:0009373 regulation of transcription, DNA-templated; • histone H4-K5 acetylation; • histone acetylation; • histone H4-K8 acetylation; • histone H4-K16 acetylation; • histone H3-K14 acetylation; • histone H2A acetylation; • transcription, DNA-templated; • regulation of signal transduction by p53 class mediator; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization; • histone H3-K23 acetylation;
	Izvori:Amigo / QuickGO
Ortolozi
	64769
	70088
	ENSG00000163875
	ENSMUSG00000028863
	Q9HAF1
	Q2VPQ9
	NM_001270875; NM_001270876; NM_022756
	NM_001290701; NM_027310; NM_001374123
	NP_001257804; NP_001257805; NP_073593
	NP_001277630; NP_081586; NP_001361052
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein MEAF6 vezan za modifikaciju hromatina jest protein koji je kod ljudi kodiran genom MEAF6 sa hromosoma 1.^[5]^[6]^[7]^[8]^[9]^[10]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 191 aminokiselina, a molekulska težina 21.635 Da.^[11]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAMHNKAAPP	QIPDTRRELA	ELVKRKQELA	ETLANLERQI	YAFEGSYLED
TQMYGNIIRG	WDRYLTNQKN	SNSKNDRRNR	KFKEAERLFS	KSSVTSAAAV
SALAGVQDQL	IEKREPGSGT	ESDTSPDFHN	QENEPSQEDP	EDLDGSVQGV
KPQKAASSTS	SGSHHSSHKK	RKNKNRHRID	LKLNKKPRAD	Y

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163875 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028863 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
^ Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
^ Cai Y, Jin J, Tomomori-Sato C, Sato S, Sorokina I, Parmely TJ, Conaway RC, Conaway JW (Oct 2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J Biol Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.
^ Doyon Y, Selleck W, Lane WS, Tan S, Cote J (Feb 2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans". Mol Cell Biol. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270.
^ Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J (Jan 2006). "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation". Mol Cell. 21 (1): 51–64. doi:10.1016/j.molcel.2005.12.007. PMID 16387653.
^ "Entrez Gene: C1orf149 chromosome 1 open reading frame 149".
^ "UniProt, Q9HAF1" (jezik: eng.). Pristupljeno 30. 11. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura[uredi | uredi izvor]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lee SY, Obata Y, Yoshida M, et al. (2003). "Immunomic analysis of human sarcoma". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2651–6. Bibcode:2003PNAS..100.2651L. doi:10.1073/pnas.0437972100. PMC 151395. PMID 12601173.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163875 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028863 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8619474-5] Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

[pmid9110174-6] Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.

[pmid12963728-7] Cai Y, Jin J, Tomomori-Sato C, Sato S, Sorokina I, Parmely TJ, Conaway RC, Conaway JW (Oct 2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J Biol Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.

[pmid14966270-8] Doyon Y, Selleck W, Lane WS, Tan S, Cote J (Feb 2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans". Mol Cell Biol. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270.

[pmid16387653-9] Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J (Jan 2006). "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation". Mol Cell. 21 (1): 51–64. doi:10.1016/j.molcel.2005.12.007. PMID 16387653.

[entrez-10] "Entrez Gene: C1orf149 chromosome 1 open reading frame 149".

[UniProt-11] "UniProt, Q9HAF1" (jezik: eng.). Pristupljeno 30. 11. 2021.CS1 održavanje: nepoznati jezik (link)

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