MIR196A2

MIR196A2
Identifikatori
Aliasi	MIR196A2
Vanjski ID-jevi	OMIM: 609687 GeneCards: MIR196A2
Lokacija gena (čovjek) Hrom. Hromosom 12 (čovjek) Bend 12q13.13 Početak 53,991,738 bp Kraj 53,991,847 bp
Ortolozi
Vrste	Čovjek	Miš
Entrez	406973	n/a
Ensembl	ENSG00000207924	n/a
UniProt	n a	n/a
RefSeq (mRNK)	n/a	n/a
RefSeq (bjelančevina)	n/a	n/a
Lokacija (UCSC)	Chr 12: 53.99 – 53.99 Mb	n/a
PubMed pretraga		n/a
Wikipodaci
Pogledaj/uredi – čovjek

MikroRNK 196a-2 je mikroRNK koja je kod ljudi kodirana genom MIR196A2. Dio je porodice prekursora Mir-196 mikroRNK.

Funkcija

mikroRNK (miRNK) su kratke (20-24 nukleotidne) nekodirajuće RNK koje su uključene u posttranskripcijsku regulaciju ekspresije gena u višećelijskim organizmima, utičući i na stabilnost i na translaciju iRNK. miRNK transkribiraju se pomoću RNK-polimeraze II, kao dio kapiranih i poliadeniliranih primarnih transkripata (pri-miRNK), koji mogu biti kodirani proteini ili nekodirani. Primarni transkript cijepa enzim drosha ribonukleaza III, kako bi se proizvela približno 70-nukleotidni prekursor miRNK, prekursora matične petlje (pre-miRNK), koji se dalje cijepa citoplazmatskom Dicer ribonukleazom kako bi nastali proizvodi zrele miRNK i antisensne miRNK zvijezdica (miRNK*). Zrela miRNK ugrađena je u kompleks za utišavanje, induciran putem RNK (RISC), koji prepoznaje ciljane iRNK putem nesavršenog uparivanja baza s miRNK i najčešće rezultira translacijskom inhibicijom ili destabilizacijom ciljane mRNK. RefSeq predstavlja predviđenu matičnu petlju mikroRNK.

Dopunska literatura

• Park YS, Jeon YJ, Lee BE, Kim TG, Choi JU, Kim DS, Kim NK (July 2012). "Association of the miR-146aC>G, miR-196a2C>T, and miR-499A>G polymorphisms with moyamoya disease in the Korean population". Neuroscience Letters. 521 (1): 71–5. doi:10.1016/j.neulet.2012.05.062. PMID 22659075. S2CID 195680110.
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• Qi P, Dou TH, Geng L, Zhou FG, Gu X, Wang H, Gao CF (June 2010). "Association of a variant in MIR 196A2 with susceptibility to hepatocellular carcinoma in male Chinese patients with chronic hepatitis B virus infection". Human Immunology. 71 (6): 621–6. doi:10.1016/j.humimm.2010.02.017. PMID 20188135.
• Dou T, Wu Q, Chen X, Ribas J, Ni X, Tang C, Huang F, Zhou L, Lu D (December 2010). "A polymorphism of microRNA196a genome region was associated with decreased risk of glioma in Chinese population". Journal of Cancer Research and Clinical Oncology. 136 (12): 1853–9. doi:10.1007/s00432-010-0844-5. PMID 20229273. S2CID 24935552.
• Mori M, Nakagami H, Rodriguez-Araujo G, Nimura K, Kaneda Y (2012). "Essential role for miR-196a in brown adipogenesis of white fat progenitor cells". PLOS Biology. 10 (4): e1001314. doi:10.1371/journal.pbio.1001314. PMC 3335871. PMID 22545021.
• Ye Y, Wang KK, Gu J, Yang H, Lin J, Ajani JA, Wu X (November 2008). "Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk". Cancer Prevention Research. 1 (6): 460–9. doi:10.1158/1940-6207.CAPR-08-0135. PMC 2768267. PMID 19138993.
• Qiu LX, Wang Y, Xia ZG, Xi B, Mao C, Wang JL, Wang BY, Lv FF, Wu XH, Hu LQ (December 2011). "miR-196a2 C allele is a low-penetrant risk factor for cancer development". Cytokine. 56 (3): 589–92. doi:10.1016/j.cyto.2011.08.019. PMID 21907588.
• Kashiyama K, Mitsutake N, Matsuse M, Ogi T, Saenko VA, Ujifuku K, Utani A, Hirano A, Yamashita S (June 2012). "miR-196a downregulation increases the expression of type I and III collagens in keloid fibroblasts". The Journal of Investigative Dermatology. 132 (6): 1597–604. doi:10.1038/jid.2012.22. hdl:10069/29204. PMID 22358059.
• Xu W, Xu J, Liu S, Chen B, Wang X, Li Y, Qian Y, Zhao W, Wu J (2011). "Effects of common polymorphisms rs11614913 in miR-196a2 and rs2910164 in miR-146a on cancer susceptibility: a meta-analysis". PLOS ONE. 6 (5): e20471. Bibcode:2011PLoSO...620471X. doi:10.1371/journal.pone.0020471. PMC 3102728. PMID 21637771.