MMP11
Stromelizin-3 (SL-3), znan i kao matriksna metaloproteinaza-11 (MMP-11) jest enzim koji je kod ljudi kodiran genom MMP11 sa hromosoma 22.[4][5][6][7]
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 488 aminokiselina, a molekulska težina 54.590 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAPAAWLRSA | AARALLPPML | LLLLQPPPLL | ARALPPDAHH | LHAERRGPQP | ||||
| WHAALPSSPA | PAPATQEAPR | PASSLRPPRC | GVPDPSDGLS | ARNRQKRFVL | ||||
| SGGRWEKTDL | TYRILRFPWQ | LVQEQVRQTM | AEALKVWSDV | TPLTFTEVHE | ||||
| GRADIMIDFA | RYWHGDDLPF | DGPGGILAHA | FFPKTHREGD | VHFDYDETWT | ||||
| IGDDQGTDLL | QVAAHEFGHV | LGLQHTTAAK | ALMSAFYTFR | YPLSLSPDDC | ||||
| RGVQHLYGQP | WPTVTSRTPA | LGPQAGIDTN | EIAPLEPDAP | PDACEASFDA | ||||
| VSTIRGELFF | FKAGFVWRLR | GGQLQPGYPA | LASRHWQGLP | SPVDAAFEDA | ||||
| QGHIWFFQGA | QYWVYDGEKP | VLGPAPLTEL | GLVRFPVHAA | LVWGPEKNKI | ||||
| YFFRGRDYWR | FHPSTRRVDS | PVPRRATDWR | GVPSEIDAAF | QDADGYAYFL | ||||
| RGRLYWKFDP | VKVKALEGFP | RLVGPDFFGC | AEPANTFL |
Funkcija[uredi | uredi izvor]
Proteini iz porodice matriksnih metaloproteinaza (MMP) uključeni su u razgradnju vanćelijskog matriksa u normalnim fiziološkim procesima, kao što su embrionski razvoj, reprodukcija i remodeliranje tkiva, kao i u procesima bolesti , kao što su artritis i metastaze. Većina MMP izlučuje se kao neaktivni proprotein koji se aktiviraju kada ih cijepaju vanćelijske proteinaze. Međutim, enzim koji je kodiran ovim genom aktivira se unutarćelijski pomoću furina unutar konstitutivnog sekretornog puta. Također, za razliku od drugih MMP, ovaj enzim cijepa alfa inhibitor 1-proteinaza, ali slabo razgrađuje strukturne proteine vanćelijskog matriksa.[7]
Reference[uredi | uredi izvor]
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000901 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Levy A, Zucman J, Delattre O, Mattei MG, Rio MC, Basset P (Aug 1992). "Assignment of the human stromelysin 3 (STMY3) gene to the q11.2 region of chromosome 22". Genomics. 13 (3): 881–3. doi:10.1016/0888-7543(92)90175-R. PMID 1639418.
- ^ Anglard P, Melot T, Guerin E, Thomas G, Basset P (Oct 1995). "Structure and promoter characterization of the human stromelysin-3 gene". J Biol Chem. 270 (35): 20337–44. doi:10.1074/jbc.270.35.20337. PMID 7657606.
- ^ Luo D, Mari B, Stoll I, Anglard P (Jul 2002). "Alternative splicing and promoter usage generates an intracellular stromelysin 3 isoform directly translated as an active matrix metalloproteinase". J Biol Chem. 277 (28): 25527–36. doi:10.1074/jbc.M202494200. PMID 12006591.
- ^ a b c "Entrez Gene: MMP11 matrix metallopeptidase 11 (stromelysin 3)".
Dopunska literatura[uredi | uredi izvor]
- Nagase H, Woessner JF (1999). "Matrix metalloproteinases". J. Biol. Chem. 274 (31): 21491–4. doi:10.1074/jbc.274.31.21491. PMID 10419448.
- Basset P, Bellocq JP, Wolf C, et al. (1991). "A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas". Nature. 348 (6303): 699–704. doi:10.1038/348699a0. PMID 1701851. S2CID 4233952.
- Pei D, Majmudar G, Weiss SJ (1994). "Hydrolytic inactivation of a breast carcinoma cell-derived serpin by human stromelysin-3". J. Biol. Chem. 269 (41): 25849–55. doi:10.1016/S0021-9258(18)47324-3. PMID 7523394.
- Pei D, Weiss SJ (1995). "Furin-dependent intracellular activation of the human stromelysin-3 zymogen" (PDF). Nature. 375 (6528): 244–7. Bibcode:1995Natur.375..244P. doi:10.1038/375244a0. hdl:2027.42/62522. PMID 7746327. S2CID 4266100.
- Boulay A, Masson R, Chenard MP, et al. (2001). "High cancer cell death in syngeneic tumors developed in host mice deficient for the stromelysin-3 matrix metalloproteinase". Cancer Res. 61 (5): 2189–93. PMID 11280785.
- Perret AG, Duthel R, Fotso MJ, et al. (2002). "Stromelysin-3 is expressed by aggressive meningiomas". Cancer. 94 (3): 765–72. doi:10.1002/cncr.10270. PMID 11857311. S2CID 26088137.
- Nakopoulou L, Panayotopoulou EG, Giannopoulou I, et al. (2003). "Stromelysin-3 protein expression in invasive breast cancer: relation to proliferation, cell survival and patients' outcome". Mod. Pathol. 15 (11): 1154–61. doi:10.1097/01.MP.0000037317.84782.CD. PMID 12429794.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wasenius VM, Hemmer S, Kettunen E, et al. (2003). "Hepatocyte growth factor receptor, matrix metalloproteinase-11, tissue inhibitor of metalloproteinase-1, and fibronectin are up-regulated in papillary thyroid carcinoma: a cDNA and tissue microarray study". Clin. Cancer Res. 9 (1): 68–75. PMID 12538453.
- Fromigué O, Louis K, Wu E, et al. (2003). "Active stromelysin-3 (MMP-11) increases MCF-7 survival in three-dimensional Matrigel culture via activation of p42/p44 MAP-kinase". Int. J. Cancer. 106 (3): 355–63. doi:10.1002/ijc.11232. PMID 12845673. S2CID 27594080.
- Skoglund J, Emterling A, Arbman G, et al. (2004). "Clinicopathological significance of stromelysin-3 expression in colorectal cancer". Oncology. 67 (1): 67–72. doi:10.1159/000080288. PMID 15459498. S2CID 23298126.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Louis K, Guérineau N, Fromigué O, et al. (2005). "Tumor cell-mediated induction of the stromal factor stromelysin-3 requires heterotypic cell contact-dependent activation of specific protein kinase C isoforms". J. Biol. Chem. 280 (2): 1272–83. doi:10.1074/jbc.M405482200. PMID 15509588.
- Deng H, Guo RF, Li WM, et al. (2005). "Matrix metalloproteinase 11 depletion inhibits cell proliferation in gastric cancer cells". Biochem. Biophys. Res. Commun. 326 (2): 274–81. doi:10.1016/j.bbrc.2004.11.027. PMID 15582574.
- Arora S, Kaur J, Sharma C, et al. (2005). "Stromelysin 3, Ets-1, and vascular endothelial growth factor expression in oral precancerous and cancerous lesions: correlation with microvessel density, progression, and prognosis". Clin. Cancer Res. 11 (6): 2272–84. doi:10.1158/1078-0432.CCR-04-0572. PMID 15788677.
- Vazquez-Ortiz G, Pina-Sanchez P, Vazquez K, et al. (2006). "Overexpression of cathepsin F, matrix metalloproteinases 11 and 12 in cervical cancer". BMC Cancer. 5: 68. doi:10.1186/1471-2407-5-68. PMC 1175083. PMID 15989693.
