MOSC1

MTARC1
Identifikatori
Aliasi	MTARC1
Vanjski ID-jevi	OMIM: 614126 MGI: 1913362 HomoloGene: 129604 GeneCards: MTARC1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	220,819,659 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	184,543,510 bp
Ontologija gena
Molekularna funkcija	• molybdopterin cofactor binding; • molybdenum ion binding; • oxidoreductase activity; • pyridoxal phosphate binding; • nitrate reductase activity; • catalytic activity;
Ćelijska komponenta	• integral component of membrane; • membrana; • mitohondrija; • mitochondrial outer membrane;
Biološki proces	• detoxification of nitrogen compound; • nitrate metabolic process; • xenobiotic metabolic process; • metabolizam;
	Izvori:Amigo / QuickGO
Ortolozi
	64757
	66112
	ENSG00000186205
	ENSMUSG00000026621
	Q5VT66
	Q9CW42
	NM_022746
	NM_001081361; NM_001290273
	NP_073583
	NP_001277202
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Mitohondrijska amidoksim-reducirajuća komponenta 1, znana i kao protein 1 sa MOCO sulfuraznim C-terminalnim domenom, MOSC1 ili MARC1, jest enzim koji je kod ljudi kodiran genom sa hromosoma 1.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 337 aminokiselina, a molekulska težina 37.499 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGAAGSSALA	RFVLLAQSRP	GWLGVAALGL	TAVALGAVAW	RRAWPTRRRR
LLQQVGTVAQ	LWIYPVKSCK	GVPVSEAECT	AMGLRSGNLR	DRFWLVINQE
GNMVTARQEP	RLVLISLTCD	GDTLTLSAAY	TKDLLLPIKT	PTTNAVHKCR
VHGLEIEGRD	CGEATAQWIT	SFLKSQPYRL	VHFEPHMRPR	RPHQIADLFR
PKDQIAYSDT	SPFLILSEAS	LADLNSRLEK	KVKATNFRPN	IVISGCDVYA
EDSWDELLIG	DVELKRVMAC	SRCILTTVDP	DTGVMSRKEP	LETLKSYRQC
DPSERKLYGK	SPLFGQYFVL	ENPGTIKVGD	PVYLLGQ

Funkcija[uredi | uredi izvor]

MOCO je engleska skraćenica za molibdenski [[kofaktor (biohemija)|cofaktor.

Prijavljeno je da MOSC1 reducira amidoksime na amidine.^[8]^[9]

Prijavljeno je da su genetičke varijacije MARC1 povezane sa nižim nivoima holesterola u krvi, nivoima jetrenih enzima u krvi, smanjenom masnoćom jetre i zaštitom od ciroze, što sugeriše da nedostatak MARC1 može zaštititi od bolesti jetre.^[10]

Također pogledajte[uredi | uredi izvor]

MOCOS

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186205 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026621 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Anantharaman V, Aravind L (januar 2002). "MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases". FEMS Microbiol. Lett. 207 (1): 55–61. doi:10.1016/S0378-1097(01)00515-8. PMID 11886751.
^ "Entrez Gene: Mitochondrial amidoxime reducing component 1". Pristupljeno 3. 3. 2016.
^ "UniProt, Q5VT66" (jezik: engleski). Pristupljeno 14. 12. 2021.
^ Havemeyer A, Bittner F, Wollers S, Mendel R, Kunze T, Clement B (novembar 2006). "Identification of the missing component in the mitochondrial benzamidoxime prodrug-converting system as a novel molybdenum enzyme". J. Biol. Chem. 281 (46): 34796–802. doi:10.1074/jbc.M607697200. PMID 16973608.
^ Gruenewald S, Wahl B, Bittner F, Hungeling H, Kanzow S, Kotthaus J, Schwering U, Mendel RR, Clement B (decembar 2008). "The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs". J. Med. Chem. 51 (24): 8173–7. doi:10.1021/jm8010417. PMID 19053771.
^ Kathiresan, Sekar; Gabriel, Stacey; Denny, Joshua; Daly, Mark; Saleheen, Danish; Danesh, John; Gupta, Namrata; Erdmann, Jeanette; Baber, Usman (31. 3. 2019). "A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease". bioRxiv (jezik: engleski). 16 (4): 594523. doi:10.1101/594523. PMC 7200007. PMID 32282858.

Vanjski linkovi[uredi | uredi izvor]

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186205 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026621 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11886751-5] Anantharaman V, Aravind L (januar 2002). "MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases". FEMS Microbiol. Lett. 207 (1): 55–61. doi:10.1016/S0378-1097(01)00515-8. PMID 11886751.

[entrez-6] "Entrez Gene: Mitochondrial amidoxime reducing component 1". Pristupljeno 3. 3. 2016.

[UniProt-7] "UniProt, Q5VT66" (jezik: engleski). Pristupljeno 14. 12. 2021.

[pmid16973608-8] Havemeyer A, Bittner F, Wollers S, Mendel R, Kunze T, Clement B (novembar 2006). "Identification of the missing component in the mitochondrial benzamidoxime prodrug-converting system as a novel molybdenum enzyme". J. Biol. Chem. 281 (46): 34796–802. doi:10.1074/jbc.M607697200. PMID 16973608.

[pmid19053771-9] Gruenewald S, Wahl B, Bittner F, Hungeling H, Kanzow S, Kotthaus J, Schwering U, Mendel RR, Clement B (decembar 2008). "The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs". J. Med. Chem. 51 (24): 8173–7. doi:10.1021/jm8010417. PMID 19053771.

[10] Kathiresan, Sekar; Gabriel, Stacey; Denny, Joshua; Daly, Mark; Saleheen, Danish; Danesh, John; Gupta, Namrata; Erdmann, Jeanette; Baber, Usman (31. 3. 2019). "A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease". bioRxiv (jezik: engleski). 16 (4): 594523. doi:10.1101/594523. PMC 7200007. PMID 32282858.

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