MSTO1

MSTO1
Identifikatori
Aliasi	MSTO1
Vanjski ID-jevi	OMIM: 617619 MGI: 2385175 HomoloGene: 41228 GeneCards: MSTO1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	155,614,951 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	88,821,306 bp
Ontologija gena
Molekularna funkcija	• molekularna funkcija;
Ćelijska komponenta	• mitochondrial outer membrane; • mitohondrija; • membrana; • citoplazma;
Biološki proces	• mitochondrion organization; • mitochondrion distribution; • mitochondrial genome maintenance; • mitotic sister chromatid segregation; • mitotic spindle assembly;
	Izvori:Amigo / QuickGO
Ortolozi
	55154
	229524
	ENSG00000125459
	ENSMUSG00000068922
	Q9BUK6
	Q2YDW2
NM_001256532; NM_001256533; NM_018116; NM_001350772; NM_001350773;
	NM_001350774; NM_001350775; NM_001350776; NM_001350777; NM_001350778; NM_001350779; NM_001350780; NM_001350781; NM_001350782; NM_001350783; NM_001350784; NM_001350785; NM_001350786; NM_001350787; NM_001350788; NM_001350789
	NM_144898
NP_001243461; NP_001243462; NP_060586; NP_001337701; NP_001337702;
	NP_001337703; NP_001337704; NP_001337705; NP_001337706; NP_001337707; NP_001337708; NP_001337709; NP_001337710; NP_001337711; NP_001337712; NP_001337713; NP_001337714; NP_001337715; NP_001337716; NP_001337717; NP_001337718
	NP_659147
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Proteinski misato homolog 1 jest protein koji je kod ljudi kodiran genom MSTO1 sa hromosoma 1.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 570 aminokiselina, a molekulska težina 61.835 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAGGAREVLT	LQLGHFAGFV	GAHWWNQQDA	ALGRATDSKE	PPGELCPDVL
YRTGRTLHGQ	ETYTPRLILM	DLKGSLSSLK	EEGGLYRDKQ	LDAAIAWQGK
LTTHKEELYP	KNPYLQDFLS	AEGVLSSDGV	WRVKSIPNGK	GSSPLPTATT
PKPLIPTEAS	IRVWSDFLRV	HLHPRSICMI	QKYNHDGEAG	RLEAFGQGES
VLKEPKYQEE	LEDRLHFYVE	ECDYLQGFQI	LCDLHDGFSG	VGAKAAELLQ
DEYSGRGIIT	WGLLPGPYHR	GEAQRNIYRL	LNTAFGLVHL	TAHSSLVCPL
SLGGSLGLRP	EPPVSFPYLH	YDATLPFHCS	AILATALDTV	TVPYRLCSSP
VSMVHLADML	SFCGKKVVTA	GAIIPFPLAP	GQSLPDSLMQ	FGGATPWTPL
SACGEPSGTR	CFAQSVVLRG	IDRACHTSQL	TPGTPPPSAL	HACTTGEEIL
AQYLQQQQPG	VMSSSHLLLT	PCRVAPPYPH	LFSSCSPPGM	VLDGSPKGAA
VESIPVFGAL	CSSSSLHQTL	EALARDLTKL	DLRRWASFMD	AGVEHDDVAE
LLQELQSLAQ	CYQGGDSLVD

Struktura[uredi | uredi izvor]

MSTO1 gen ima 5134 para baza (lociranih u hromosomu 1), a MSTO1 protein je dug 570 aminokiselina. Nalazi se u vanjskoj membrani mitohondrija i uključen je u regulaciju mitohondrijske distribucije i morfologije.^[8]

Protein misato sadrži N-terminalni miozinski domen sličan misato segmentu II i centralni domen tubulina.^[8]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125459 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000068922 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kuryshev VY, Vorobyov E, Zink D, Schmitz J, Rozhdestvensky TS, Munstermann E, Ernst U, Wellenreuther R, Moosmayer P, Bechtel S, Schupp I, Horst J, Korn B, Poustka A, Wiemann S (Jul 2006). "An anthropoid-specific segmental duplication on human chromosome 1q22". Genomics. 88 (2): 143–51. doi:10.1016/j.ygeno.2006.02.002. PMID 16545939.
^ "Entrez Gene: MSTO1 misato homolog 1 (Drosophila)".
^ "UniProt, Q9BUK6" (jezik: engleski). Pristupljeno 14. 12. 2021.
^ ^a ^b Kimura M, Okano Y (april 2007). "Human Misato regulates mitochondrial distribution and morphology". Exp. Cell Res. 313 (7): 1393–404. doi:10.1016/j.yexcr.2007.02.004. PMID 17349998.

Dopunska literatura[uredi | uredi izvor]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Miklos GL, Yamamoto M, Burns RG, Maleszka R (1997). "An essential cell division gene of Drosophila, absent from Saccharomyces, encodes an unusual protein with tubulin-like and myosin-like peptide motifs". Proc. Natl. Acad. Sci. U.S.A. 94 (10): 5189–94. Bibcode:1997PNAS...94.5189M. doi:10.1073/pnas.94.10.5189. PMC 24654. PMID 9144213.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125459 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000068922 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16545939-5] Kuryshev VY, Vorobyov E, Zink D, Schmitz J, Rozhdestvensky TS, Munstermann E, Ernst U, Wellenreuther R, Moosmayer P, Bechtel S, Schupp I, Horst J, Korn B, Poustka A, Wiemann S (Jul 2006). "An anthropoid-specific segmental duplication on human chromosome 1q22". Genomics. 88 (2): 143–51. doi:10.1016/j.ygeno.2006.02.002. PMID 16545939.

[entrez-6] "Entrez Gene: MSTO1 misato homolog 1 (Drosophila)".

[UniProt-7] "UniProt, Q9BUK6" (jezik: engleski). Pristupljeno 14. 12. 2021.

[pmid17349998-8] Kimura M, Okano Y (april 2007). "Human Misato regulates mitochondrial distribution and morphology". Exp. Cell Res. 313 (7): 1393–404. doi:10.1016/j.yexcr.2007.02.004. PMID 17349998.

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