MTERF

MTERF
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	3MVA, 3MVB, 3N6S, 3N7Q, 5CO0, 5CRJ, 5CKY, 5CRK
Identifikatori
Aliasi	MTERF1
Vanjski ID-jevi	OMIM: 602318 MGI: 3704243 HomoloGene: 5073 GeneCards: MTERF1
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	91,880,702 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	4,247,651 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • GO:0001948, GO:0016582 vezivanje za proteine; • double-stranded DNA binding; • vezivanje sa RNK;
Ćelijska komponenta	• mitochondrial matrix; • mitochondrial nucleoid; • mitohondrija; • citosol;
Biološki proces	• termination of mitochondrial transcription; • mitochondrion organization; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • DNA geometric change; • DNA-templated transcription, termination;
	Izvori:Amigo / QuickGO
Ortolozi
	7978
	208595
	ENSG00000127989
	ENSMUSG00000053178
	Q99551
	B9EJ57
	NM_001301134; NM_001301135; NM_006980
	NM_001042670
	NP_001288063; NP_001288064; NP_008911
	NP_001036135
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Mitohondrijskoterminacjski faktor transkripcije 1, znan i kao aMTERF1, jest protein koji je kod ljudi kodiran genom MTERF.^[5]^[6]^[7]^[8]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 399 aminokiselina, а molekulska težina 45.778 Da.^[9]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MQSLSLGQTS	ISKGLNYLTI	MAPGNLWHMR	NNFLFGSRCW	MTRFSAENIF
KSVSFRLFGV	KCHNTDSEPL	KNEDLLKNLL	TMGVDIDMAR	KRQPGVFHRM
ITNEQDLKMF	LLSKGASKEV	IASIISRYPR	AITRTPENLS	KRWDLWRKIV
TSDLEIVNIL	ERSPESFFRS	NNNLNLENNI	KFLYSVGLTR	KCLCRLLTNA
PRTFSNSLDL	NKQMVEFLQA	AGLSLGHNDP	ADFVRKIIFK	NPFILIQSTK
RVKANIEFLR	STFNLNSEEL	LVLICGPGAE	ILDLSNDYAR	RSYANIKEKL
FSLGCTEEEV	QKFVLSYPDV	IFLAEKKFND	KIDCLMEENI	SISQIIENPR
VLDSSISTLK	SRIKELVNAG	CNLSTLNITL	LSWSKKRYEA	KLKKLSRFA

Funkcija[uredi | uredi izvor]

Ovaj gen kodira transkripciju terminacijskog faktora u mitohondrijama. Protein učestvuje u slabljenju transkripcije iz mitohondrijskog genoma; ovo slabljenje omogućava veće nivoe ekspresije 16S ribosomske RNK u odnosu na nizvodni gen za tRNK. Proizvod ovog gena ima tri motiva leucinskog zatvarača koji su u pregradama povezani s dva osnovna domena koji su oba potrebna za vezivanje DNK. Postoje dokazi da za ovaj protein zatvarači sudjeluju u intramolekulnim interakcijama koje uspostavljaju trodimenzijsku strukturu potrebnu za vezanje DNK.^[5]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127989 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053178 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: MTERF mitochondrial transcription termination factor".
^ Daga A, Micol V, Hess D, Aebersold R, Attardi G (april 1993). "Molecular characterization of the transcription termination factor from human mitochondria". J. Biol. Chem. 268 (11): 8123–30. doi:10.1016/S0021-9258(18)53070-2. PMID 7681833. Arhivirano s originala, 17. 4. 2020. Pristupljeno 27. 9. 2021.
^ Asin-Cayuela J, Helm M, Attardi G (april 2004). "A monomer-to-trimer transition of the human mitochondrial transcription termination factor (mTERF) is associated with a loss of in vitro activity". J. Biol. Chem. 279 (15): 15670–7. doi:10.1074/jbc.M312537200. PMID 14744862.
^ Asin-Cayuela J, Schwend T, Farge G, Gustafsson CM (juli 2005). "The human mitochondrial transcription termination factor (mTERF) is fully active in vitro in the non-phosphorylated form". J. Biol. Chem. 280 (27): 25499–505. doi:10.1074/jbc.M501145200. PMID 15899902.
^ "UniProt, Q99551" (jezik: engleski). Pristupljeno 27. 9. 2021.

Dopunska literatura[uredi | uredi izvor]

Daga A, Micol V, Hess D, et al. (1993). "Molecular characterization of the transcription termination factor from human mitochondria". J. Biol. Chem. 268 (11): 8123–30. doi:10.1016/S0021-9258(18)53070-2. PMID 7681833.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Fernandez-Silva P, Martinez-Azorin F, Micol V, Attardi G (1997). "The human mitochondrial transcription termination factor (mTERF) is a multizipper protein but binds to DNA as a monomer, with evidence pointing to intramolecular leucine zipper interactions". EMBO J. 16 (5): 1066–79. doi:10.1093/emboj/16.5.1066. PMC 1169706. PMID 9118945.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Asin-Cayuela J, Helm M, Attardi G (2004). "A monomer-to-trimer transition of the human mitochondrial transcription termination factor (mTERF) is associated with a loss of in vitro activity". J. Biol. Chem. 279 (15): 15670–7. doi:10.1074/jbc.M312537200. PMID 14744862.
Prieto-Martín A, Montoya J, Martínez-Azorín F (2004). "Phosphorylation of rat mitochondrial transcription termination factor (mTERF) is required for transcription termination but not for binding to DNA". Nucleic Acids Res. 32 (7): 2059–68. doi:10.1093/nar/gkh528. PMC 407814. PMID 15087485.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Asin-Cayuela J, Schwend T, Farge G, Gustafsson CM (2005). "The human mitochondrial transcription termination factor (mTERF) is fully active in vitro in the non-phosphorylated form". J. Biol. Chem. 280 (27): 25499–505. doi:10.1074/jbc.M501145200. PMID 15899902.
Hyvärinen AK, Pohjoismäki JL, Reyes A, et al. (2007). "The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA". Nucleic Acids Res. 35 (19): 6458–74. doi:10.1093/nar/gkm676. PMC 2095818. PMID 17884915.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000127989 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053178 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MTERF mitochondrial transcription termination factor".

[pmid7681833-6] Daga A, Micol V, Hess D, Aebersold R, Attardi G (april 1993). "Molecular characterization of the transcription termination factor from human mitochondria". J. Biol. Chem. 268 (11): 8123–30. doi:10.1016/S0021-9258(18)53070-2. PMID 7681833. Arhivirano s originala, 17. 4. 2020. Pristupljeno 27. 9. 2021.

[pmid14744862-7] Asin-Cayuela J, Helm M, Attardi G (april 2004). "A monomer-to-trimer transition of the human mitochondrial transcription termination factor (mTERF) is associated with a loss of in vitro activity". J. Biol. Chem. 279 (15): 15670–7. doi:10.1074/jbc.M312537200. PMID 14744862.

[pmid15899902-8] Asin-Cayuela J, Schwend T, Farge G, Gustafsson CM (juli 2005). "The human mitochondrial transcription termination factor (mTERF) is fully active in vitro in the non-phosphorylated form". J. Biol. Chem. 280 (27): 25499–505. doi:10.1074/jbc.M501145200. PMID 15899902.

[UniProt-9] "UniProt, Q99551" (jezik: engleski). Pristupljeno 27. 9. 2021.

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