MTO1

MTO1
Identifikatori
Aliasi	MTO1
Vanjski ID-jevi	OMIM: 614667 MGI: 1915541 HomoloGene: 5876 GeneCards: MTO1
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	73,509,236 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	78,382,630 bp
Ontologija gena
Molekularna funkcija	• flavin adenine dinucleotide binding; • vezivanje sa RNK;
Ćelijska komponenta	• mitohondrija;
Biološki proces	• tRNA methylation; • mitochondrial tRNA wobble uridine modification; • tRNA processing; • tRNA wobble uridine modification;
	Izvori:Amigo / QuickGO
Ortolozi
	25821
	68291
	ENSG00000135297
	ENSMUSG00000032342
	Q9Y2Z2
	Q923Z3
	NM_001123226; NM_012123; NM_133645
	NM_026658
	NP_001116698; NP_036255; NP_598400
	NP_080934
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Mitohondrijski homolog proteina MTO1 jest protein koji je kod ljudi kodiran genom MTO1.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 717 aminokiselina, а molekulska težina 79.964 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MFYFRGCGRW	VAVSFTKQQF	PLARLSSDSA	APRTPHFDVI	VIGGGHAGTE
AATAAARCGS	RTLLLTHRVD	TIGQMSCNPS	FGGIGKGHLM	REVDALDGLC
SRICDQSGVH	YKVLNRRKGP	AVWGLRAQID	RKLYKQNMQK	EILNTPLLTV
QEGAVEDLIL	TEPEPEHTGK	CRVSGVVLVD	GSTVYAESVI	LTTGTFLRGM
IVIGLETHPA	GRLGDQPSIG	LAQTLEKLGF	VVGRLKTGTP	PRIAKESINF
SILNKHIPDN	PSIPFSFTNE	TVWIKPEDQL	PCYLTHTNPR	VDEIVLKNLH
LNSHVKETTR	GPRYCPSIES	KVLRFPNRLH	QVWLEPEGMD	SDLIYPQGLS
MTLPAELQEK	MITCIRGLEK	AKVIQPDGVL	LLLPRMECNG	AISAHHNLPL
PGYGVQYDYL	DPRQITPSLE	THLVQRLFFA	GQINGTTGYE	EAAAQGVIAG
INASLRVSRK	PPFVVSRTEG	YIGVLIDDLT	TLGTSEPYRM	FTSRVEFRLS
LRPDNADSRL	TLRGYKDAGC	VSQQRYERAC	WMKSSLEEGI	SVLKSIEFLS
SKWKKLIPEA	SISTSRSLPV	RALDVLKYEE	VDMDSLAKAV	PEPLKKYTKC
RELAERLKIE	ATYESVLFHQ	LQEIKGVQQD	EALQLPKDLD	YLTIRDVSLS
HEVREKLHFS	RPQTIGAASR	IPGVTPAAII	NLLRFVKTTQ	RRQSAMNESS
KTDQYLCDAD	RLQEREL

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135297 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032342 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Li X, Li R, Lin X, Guan MX (Jul 2002). "Isolation and characterization of the putative nuclear modifier gene MTO1 involved in the pathogenesis of deafness-associated mitochondrial 12 S rRNA A1555G mutation". J Biol Chem. 277 (30): 27256–64. doi:10.1074/jbc.M203267200. PMID 12011058.
^ "Entrez Gene: MTO1 mitochondrial translation optimization 1 homolog (S. cerevisiae)".
^ "UniProt, Q9Y2Z2" (jezik: engleski). Pristupljeno 9. 10. 2021.

Dopunska literatura[uredi | uredi izvor]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Bykhovskaya Y, Mengesha E, Wang D, et al. (2005). "Phenotype of non-syndromic deafness associated with the mitochondrial A1555G mutation is modulated by mitochondrial RNA modifying enzymes MTO1 and GTPBP3". Mol. Genet. Metab. 83 (3): 199–206. doi:10.1016/j.ymgme.2004.07.009. PMID 15542390.
Krull M, Brosius J, Schmitz J (2005). "Alu-SINE exonization: en route to protein-coding function". Mol. Biol. Evol. 22 (8): 1702–11. doi:10.1093/molbev/msi164. PMID 15901843.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135297 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032342 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12011058-5] Li X, Li R, Lin X, Guan MX (Jul 2002). "Isolation and characterization of the putative nuclear modifier gene MTO1 involved in the pathogenesis of deafness-associated mitochondrial 12 S rRNA A1555G mutation". J Biol Chem. 277 (30): 27256–64. doi:10.1074/jbc.M203267200. PMID 12011058.

[entrez-6] "Entrez Gene: MTO1 mitochondrial translation optimization 1 homolog (S. cerevisiae)".

[UniProt-7] "UniProt, Q9Y2Z2" (jezik: engleski). Pristupljeno 9. 10. 2021.

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