MYBL1

MYBL1
Identifikatori
Aliasi	MYBL1
Vanjski ID-jevi	OMIM: 159405 MGI: 99925 HomoloGene: 32045 GeneCards: MYBL1
Lokacija gena (čovjek) Hrom. Hromosom 8 (čovjek) Bend 8q13.1 Početak 66,562,175 bp Kraj 66,614,247 bp
Lokacija gena (miš) Hrom. Hromosom 1 (miš) Bend 1 A2|1 2.08 cM Početak 9,737,640 bp Kraj 9,770,434 bp
Ontologija gena Molekularna funkcija • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • vezivanje sa DNK • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • jedro Biološki proces • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • GO:0007067 Mitoza • male meiosis I • Spermatogeneza • negative regulation of transposition • Ćelijska diferencijacija • piRNA biosynthetic process Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	4603	17864
Ensembl	ENSG00000185697	ENSMUSG00000025912
UniProt	P10243	P51960
RefSeq (mRNK)	NM_001080416 NM_001144755 NM_001294282	NM_001290397 NM_008651
RefSeq (bjelančevina)	NP_001073885 NP_001138227 NP_001281211	NP_001277326 NP_032677
Lokacija (UCSC)	Chr 8: 66.56 – 66.61 Mb	Chr 1: 9.74 – 9.77 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

MYB proto-onkogenoliki protein 1 je protein koji je kod ljudi kodiran genom MYBL1.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 752 aminokiseline, а molekulska težina 85.887 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MAKRSRSEDE		DDDLQYADHD		YEVPQQKGLK		KLWNRVKWTR		DEDDKLKKLV
EQHGTDDWTL		IASHLQNRSD		FQCQHRWQKV		LNPELIKGPW		TKEEDQRVIE
LVQKYGPKRW		SLIAKHLKGR		IGKQCRERWH		NHLNPEVKKS		SWTEEEDRII
YEAHKRLGNR		WAEIAKLLPG		RTDNSIKNHW		NSTMRRKVEQ		EGYLQDGIKS
ERSSSKLQHK		PCAAMDHMQT		QNQFYIPVQI		PGYQYVSPEG		NCIEHVQPTS
AFIQQPFIDE		DPDKEKKIKE		LEMLLMSAEN		EVRRKRIPSQ		PGSFSSWSGS
FLMDDNMSNT		LNSLDEHTSE		FYSMDENQPV		SAQQNSPTKF		LAVEANAVLS
SLQTIPEFAE		TLELIESDPV		AWSDVTSFDI		SDAAASPIKS		TPVKLMRIQH
NEGAMECQFN		VSLVLEGKKN		TCNGGNSEAV		PLTSPNIAKF		STPPAILRKK
RKMRVGHSPG		SELRDGSLND		GGNMALKHTP		LKTLPFSPSQ		FFNTCPGNEQ
LNIENPSFTS		TPICGQKALI		TTPLHKETTP		KDQKENVGFR		TPTIRRSILG
TTPRTPTPFK		NALAAQEKKY		GPLKIVSQPL		AFLEEDIREV		LKEETGTDLF
LKEEDEPAYK		SCKQENTASG		KKVRKSLVLD		NWEKEESGTQ		LLTEDISDMQ
SENRFTTSLL		MIPLLEIHDN		RCNLIPEKQD		INSTNKTYTL		TKKKPNPNTS
KVVKLEKNLQ		SNCEWETVVY		GKTEDQLIMT		EQARRYLSTY		TATSSTSRAL
IL

Dopunska literatura

• Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, Schumacher SE, McKenna A, Lawrence MS, Bergthold G, Brastianos PK, Tabak B, Ducar MD, Van Hummelen P, MacConaill LE, Pouissant-Young T, Cho YJ, Taha H, Mahmoud M, Bowers DC, Margraf L, Tabori U, Hawkins C, Packer RJ, Hill DA, Pomeroy SL, Eberhart CG, Dunn IF, Goumnerova L, Getz G, Chan JA, Santagata S, Hahn WC, Stiles CD, Ligon AH, Kieran MW, Beroukhim R, Ligon KL (2013). "Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1". Proc. Natl. Acad. Sci. U.S.A. 110 (20): 8188–93. Bibcode:2013PNAS..110.8188R. doi:10.1073/pnas.1300252110. PMC 3657784. PMID 23633565.