MYRIP

MYRIP
Identifikatori
Aliasi	MYRIP
Vanjski ID-jevi	OMIM: 611790 MGI: 2384407 HomoloGene: 9150 GeneCards: MYRIP
Lokacija gena (čovjek) Hrom. Hromosom 3 (čovjek) Bend 3p22.1 Početak 39,808,914 bp Kraj 40,260,321 bp
Lokacija gena (miš) Hrom. Hromosom 9 (miš) Bend 9|9 F4 Početak 120,130,579 bp Kraj 120,303,907 bp
Ontologija gena Molekularna funkcija • protein kinase A binding • vezivanje iona cinka • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje iona metala • actin binding • myosin binding Ćelijska komponenta • citoplazma • Melanosom • perinuklearno područje citoplazme • photoreceptor outer segment • exocyst • sinapsa • dense core granule • transport vesicle • GO:0016023 citoplazmatska vezikula • actin cytoskeleton • cortical actin cytoskeleton Biološki proces • intracellular protein transport • positive regulation of insulin secretion • vesicle transport along actin filament Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	25924	245049
Ensembl	ENSG00000170011	ENSMUSG00000041794
UniProt	Q8NFW9	Q8K3I4
RefSeq (mRNK)	NM_001284423 NM_001284424 NM_001284425 NM_001284426 NM_015460	NM_144557
RefSeq (bjelančevina)	NP_001271352 NP_001271353 NP_001271354 NP_001271355 NP_056275	NP_653140
Lokacija (UCSC)	Chr 3: 39.81 – 40.26 Mb	Chr 9: 120.13 – 120.3 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Miozinski VIIA i Rab interaktivni protein jest protein koji je kod ljudi kodiran genom MYRIP sa hromosoma 3.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 859 aminokiselina, а molekulska težina 95.706 Da..

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MGRKLDLSGL		TDDETEHVLQ		VVQRDFNLRK		KEEERLSELK		QKLDEEGSKC
SILSKHQQFV		EHCCMRCCSP		FTFLVNTKRQ		CGDCKFNVCK		SCCSYQKHEK
AWVCCVCQQA		RLLRAQSLEW		FYNNVKSRFK		RFGSAKVLKN		LYRKHRLESG
ACFDILGGSL		FESNLENEGS		ISGSDSTFYR		QSEGHSVMDT		LAVALRVAEE
AIEEAISKAE		AYGDSLDKQN		EASYLRDHKE		ELTEELATTI		LQKIIRKQKS
KSEQQVEEEP		GWPHPQSCST		KVADEGTSAS		PGGYRAPAAL		WRSQSAFSIT
GEEALKTPPV		EAPSRQPRDQ		GQHPRAESAL		PSWKSVDRLD		ETNLAPVLQS
PDGNWVALKD		GAPPPTRLLA		KPKSGTFQAL		EVASSVASAY		DEMGSDSEED
FDWSEALSKL		CPRSRALPRN		PQPQPTQAQS		SDQGPIAASP		SSALSPNPEA
MCSDSETSSA		GSSREVGHQA		RLSWLQRKAP		RNPAAEKMRL		HGELDVNFNP
QLASRETSDS		SEPEEAPHTT		DRRARRWRRA		RLGSEEPSKE		PSSPSAQLRD
LDTHQVSDDL		SETDISNEAR		DPQTLTDTTE		EKRRNRLYEL		AMKMSEKETS
SGEDQESEPK		TESENQKESL		SSEDNSQSVQ		EELKKKFSAV		SLCNISTEVL
KVINATEELI		AGSTGPWESP		QVPPDRQKGM		FPRGTDQVRL		DEQLTSLEEN
VYLAAGTVYG		LETQLTELED		AARCIHSGTD		ETHLADLEDQ		VATAAAQVHH
AELQISDIES		RISALTIAGL		NIAPCVRFTR		RRDQKQRTQV		QTIDTSRQQR
RKLPAPPVKA		EKIETSSVTT		IKTFNHNFIL		QGSSTNRTKE		RKGTTKDLME
PALESAVMY

Dopunska literatura

• El-Amraoui A, Schonn JS, Küssel-Andermann P, Blanchard S, Desnos C, Henry JP, Wolfrum U, Darchen F, Petit C (2002). "MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes". EMBO Rep. 3 (5): 463–70. doi:10.1093/embo-reports/kvf090. PMC 1084103. PMID 11964381.