PDF (gen)
(Preusmjereno sa Mitohondrijska peptid-deformilaza)
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| Aliasi | |||||||||||||||||||||||||
| Vanjski ID-jevi | MGI: 1915273 HomoloGene: 69354 GeneCards: PDF | ||||||||||||||||||||||||
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| Vrste | Čovjek | Miš | |||||||||||||||||||||||
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| RefSeq (mRNK) | |||||||||||||||||||||||||
| RefSeq (bjelančevina) | |||||||||||||||||||||||||
| Lokacija (UCSC) | Chr 16: 69.33 – 69.33 Mb | Chr 8: 107.77 – 107.78 Mb | |||||||||||||||||||||||
| PubMed pretraga | [3] | [4] | |||||||||||||||||||||||
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Mitohondrijska peptid-deformilaza je enzim koji je kod ljudi kodiran genom PDF.[5][6][7]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 243 aminokiseline, a molekulska težina 27.013 Da[8].
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MARLWGALSL | WPLWAAVPWG | GAAAVGVRAC | SSTAAPDGVE | GPALRRSYWR | ||||
| HLRRLVLGPP | EPPFSHVCQV | GDPVLRGVAA | PVERAQLGGP | ELQRLTQRLV | ||||
| QVMRRRRCVG | LSAPQLGVPR | QVLALELPEA | LCRECPPRQR | ALRQMEPFPL | ||||
| RVFVNPSLRV | LDSRLVTFPE | GCESVAGFLA | CVPRFQAVQI | SGLDPNGEQV | ||||
| VWQASGWAAR | IIQHEMDHLQ | GCLFIDKMDS | RTFTNVYWMK | VND |
Također poledajte
[uredi | uredi izvor]Reference
[uredi | uredi izvor]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000258429 - Ensembl, maj 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000078931 - Ensembl, maj 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Giglione C, Serero A, Pierre M, Boisson B, Meinnel T (Nov 2000). "Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms". EMBO J. 19 (21): 5916–29. doi:10.1093/emboj/19.21.5916. PMC 305796. PMID 11060042.
- ↑ Lee MD, She Y, Soskis MJ, Borella CP, Gardner JR, Hayes PA, Dy BM, Heaney ML, Philips MR, Bornmann WG, Sirotnak FM, Scheinberg DA (Oct 2004). "Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics". J Clin Invest. 114 (8): 1107–16. doi:10.1172/JCI22269. PMC 522256. PMID 15489958.
- ↑ "Entrez Gene: PDF peptide deformylase (mitochondrial)".
- ↑ "UniProt, Q9HBH1". Pristupljeno 8. 7. 2021.
Dopunska literatura
[uredi | uredi izvor]- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Lee MD, Antczak C, Li Y, et al. (2004). "A new human peptide deformylase inhibitable by actinonin". Biochem. Biophys. Res. Commun. 312 (2): 309–15. doi:10.1016/j.bbrc.2003.10.123. PMID 14637138.
- Serero A, Giglione C, Sardini A, et al. (2004). "An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway". J. Biol. Chem. 278 (52): 52953–63. doi:10.1074/jbc.M309770200. PMID 14532271.
- Nguyen KT, Hu X, Colton C, et al. (2003). "Characterization of a human peptide deformylase: implications for antibacterial drug design". Biochemistry. 42 (33): 9952–8. doi:10.1021/bi0346446. PMID 12924944.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". Am. J. Hum. Genet. 71 (6): 1443–9. doi:10.1086/344580. PMC 378590. PMID 12417987.