OTUD4
Protein 4 sa OTU domenom jest protein koji je kod ljudi kodiran genom OTUD4 sa hromosoma 4.[5][6][7]
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 1.114 aminokiselina, а molekulska težina 124.045 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MEAAVGVPDG | GDQGGAGPRE | DATPMDAYLR | KLGLYRKLVA | KDGSCLFRAV | ||||
| AEQVLHSQSR | HVEVRMACIH | YLRENREKFE | AFIEGSFEEY | LKRLENPQEW | ||||
| VGQVEISALS | LMYRKDFIIY | REPNVSPSQV | TENNFPEKVL | LCFSNGNHYD | ||||
| IVYPIKYKES | SAMCQSLLYE | LLYEKVFKTD | VSKIVMELDT | LEVADEDNSE | ||||
| ISDSEDDSCK | SKTAAAAADV | NGFKPLSGNE | QLKNNGNSTS | LPLSRKVLKS | ||||
| LNPAVYRNVE | YEIWLKSKQA | QQKRDYSIAA | GLQYEVGDKC | QVRLDHNGKF | ||||
| LNADVQGIHS | ENGPVLVEEL | GKKHTSKNLK | APPPESWNTV | SGKKMKKPST | ||||
| SGQNFHSDVD | YRGPKNPSKP | IKAPSALPPR | LQHPSGVRQH | AFSSHSSGSQ | ||||
| SQKFSSEHKN | LSRTPSQIIR | KPDRERVEDF | DHTSRESNYF | GLSPEERREK | ||||
| QAIEESRLLY | EIQNRDEQAF | PALSSSSVNQ | SASQSSNPCV | QRKSSHVGDR | ||||
| KGSRRRMDTE | ERKDKDSIHG | HSQLDKRPEP | STLENITDDK | YATVSSPSKS | ||||
| KKLECPSPAE | QKPAEHVSLS | NPAPLLVSPE | VHLTPAVPSL | PATVPAWPSE | ||||
| PTTFGPTGVP | APIPVLSVTQ | TLTTGPDSAV | SQAHLTPSPV | PVSIQAVNQP | ||||
| LMPLPQTLSL | YQDPLYPGFP | CNEKGDRAIV | PPYSLCQTGE | DLPKDKNILR | ||||
| FFFNLGVKAY | SCPMWAPHSY | LYPLHQAYLA | ACRMYPKVPV | PVYPHNPWFQ | ||||
| EAPAAQNESD | CTCTDAHFPM | QTEASVNGQM | PQPEIGPPTF | SSPLVIPPSQ | ||||
| VSESHGQLSY | QADLESETPG | QLLHADYEES | LSGKNMFPQP | SFGPNPFLGP | ||||
| VPIAPPFFPH | VWYGYPFQGF | IENPVMRQNI | VLPSDEKGEL | DLSLENLDLS | ||||
| KDCGSVSTVD | EFPEARGEHV | HSLPEASVSS | KPDEGRTEQS | SQTRKADTAL | ||||
| ASIPPVAEGK | AHPPTQILNR | ERETVPVELE | PKRTIQSLKE | KTEKVKDPKT | ||||
| AADVVSPGAN | SVDSRVQRPK | EESSEDENEV | SNILRSGRSK | QFYNQTYGSR | ||||
| KYKSDWGYSG | RGGYQHVRSE | ESWKGQPSRS | RDEGYQYHRN | VRGRPFRGDR | ||||
| RRSGMGDGHR | GQHT |
Funkcija[uredi | uredi izvor]
Za ovaj gen su pronađene dvije alternativno prerađene varijante transkripta koje kodiraju različite izoforme. Manja izoforma proteina kodirana kraćom varijantom transkripta nalazi se samo u ćelijama zaraženim HIV-om-1.[7]
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000164164 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036990 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Raineri I, Senn HP (Feb 1993). "HIV-1 promotor insertion revealed by selective detection of chimeric provirus-host gene transcripts". Nucleic Acids Res. 20 (23): 6261–6. doi:10.1093/nar/20.23.6261. PMC 334514. PMID 1475186.
- ^ Krop I, Maguire P, Lahti-Domenici J, Lodeiro G, Richardson A, Johannsdottir HK, Nevanlinna H, Borg A, Gelman R, Barkardottir RB, Lindblom A, Polyak K (maj 2003). "Lack of HIN-1 methylation in BRCA1-linked and "BRCA1-like" breast tumors". Cancer Res. 63 (9): 2024–7. PMID 12727813.
- ^ a b "Entrez Gene: OTUD4 OTU domain containing 4".
- ^ "UniProt, Q01804" (jezik: engleski). Pristupljeno 30. 10. 2021.
Dopunska literatura[uredi | uredi izvor]
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.