OVGP1

OVGP1
Identifikatori
Aliasi	OVGP1
Vanjski ID-jevi	OMIM: 603578 MGI: 106661 HomoloGene: 74442 GeneCards: OVGP1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	111,427,735 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	105,894,739 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• chitinase activity; • chitin binding;
Ćelijska komponenta	• egg coat; • citosol; • Perivitelinski prostor; • transport vesicle; • GO:0016023 citoplazmatska vezikula; • extracellular region; • citoplazma;
Biološki proces	• female pregnancy; • binding of sperm to zona pellucida; • negative regulation of binding of sperm to zona pellucida; • single fertilization; • chitin catabolic process; • carbohydrate metabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	5016
	12659
	ENSG00000085465
	ENSMUSG00000074340
	Q12889
	Q62010
	NM_002557
	NM_007696
	NP_002548
	NP_031722
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Jajovodno-specifični glikoprotein , znan i kao jajovodni glikoprotein (OGP) ili estrogen-ovisni jajovodni protein (EGP) ili mucin-9 (MUC9) jest protein koji je kod ljudi kodiran genom OVGP1 sa hromosoma 1.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 678 aminokiselina, a molekulska težina 75.421 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MWKLLLWVGL	VLVLKHHDGA	AHKLVCYFTN	WAHSRPGPAS	ILPHDLDPFL
CTHLIFAFAS	MNNNQIVAKD	LQDEKILYPE	FNKLKERNRE	LKTLLSIGGW
NFGTSRFTTM	LSTFANREKF	IASVISLLRT	HDFDGLDLFF	LYPGLRGSPM
HDRWTFLFLI	EELLFAFRKE	ALLTMRPRLL	LSAAVSGVPH	IVQTSYDVRF
LGRLLDFINV	LSYDLHGSWE	RFTGHNSPLF	SLPEDPKSSA	YAMNYWRKLG
APSEKLIMGI	PTYGRTFRLL	KASKNGLQAR	AIGPASPGKY	TKQEGFLAYF
EICSFVWGAK	KHWIDYQYVP	YANKGKEWVG	YDNAISFSYK	AWFIRREHFG
GAMVWTLDMD	DVRGTFCGTG	PFPLVYVLND	ILVRAEFSST	SLPQFWLSSA
VNSSSTDPER	LAVTTAWTTD	SKILPPGGEA	GVTEIHGKCE	NMTITPRGTT
VTPTKETVSL	GKHTVALGEK	TEITGAMTMT	SVGHQSMTPG	EKALTPVGHQ
SVTTGQKTLT	SVGYQSVTPG	EKTLTPVGHQ	SVTPVSHQSV	SPGGTTMTPV
HFQTETLRQN	TVAPRRKAVA	REKVTVPSRN	ISVTPEGQTM	PLRGENLTSE
VGTHPRMGNL	GLQMEAENRM	MLSSSPVIQL	PEQTPLAFDN	RFVPIYGNHS
SVNSVTPQTS	PLSLKKEIPE	NSAVDEEA

Funkcija[uredi | uredi izvor]

Glikoprotein specifičan za jajovode je veliki, bogat ugljikohidratima, epitelni glikoprotein sa brojnim O-glikozilacijskim mjestima unutar treoninom, serinom i prolinom bogatih tandemskih ponavlja. Gen je sličan članovima porodice sluznih gena i glikozil hidrolaze 18. Regulacija ekspresije može biti estrogen-ovisna. Ekspresija gena i sekrecija proteina javljaju se tokom kasnog razvoja folikula u ranoj fazi embriogeneze. Protein se luči iz epitelnih ćelija ovidukt a bez cilija i povezuje se sa ovulskimm oocitom, blastomerama i akrosomnim regijama spermatozoida.^[7]

Iza jajovoda, OVGP1 je otkriven u mišjim jajnicima, sjemenicima i epididimisu, što ukazuje na njegovu ulogu izvan oplodnje. Ne otkriva se u mišjoj maternici, grliću materice, vagini, dojkama, sjemenim vezikulama i prostati.^[9] OVGP1 je eksprimiran u površinskomm epitelu endometrija u vrijeme implantacije kod miša. Potreban je za održavanje fenotipa receptivnosti i adhezije trofoblasta, a nivoi OVGP1 iRNK smanjeni su u endometriju žena sa rekurentnim neuspjehom implantacije^[10]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000085465 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074340 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Arias EB, Verhage HG, Jaffe RC (Feb 1995). "Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein". Biol Reprod. 51 (4): 685–94. doi:10.1095/biolreprod51.4.685. PMID 7819450.
^ Lapensee L, Paquette Y, Bleau G (Nov 1997). "Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9)". Fertil Steril. 68 (4): 702–8. doi:10.1016/S0015-0282(97)00317-8. PMID 9341614.
^ ^a ^b "Entrez Gene: OVGP1 oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)".
^ "UniProt, Q12889" (jezik: eng.). Pristupljeno 3. 12. 2021.CS1 održavanje: nepoznati jezik (link)
^ Laheri, Saniya; Modi, Deepak; Bhatt, Purvi (Mar 2017). "Extra-oviductal expression of oviductal glycoprotein 1 in mouse: Detection in testis, epididymis and ovary". Journal of Biosciences. 42 (1): 69–80. doi:10.1007/s12038-016-9657-2. PMID 28229966. S2CID 10274575. Pristupljeno 16. 7. 2018.
^ Laheri, Saniya; Ashary, Nancy; Bhatt, Purvi; Modi, Deepak (2018). "Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion". Journal of Assisted Reproduction and Genetics. 35 (8): 1419–1429. doi:10.1007/s10815-018-1231-4. PMC 6086790. PMID 29968069.

Laheri, Saniya; Ashary, Nancy; Bhatt, Purvi; Modi, Deepak (2018). "Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion". Journal of Assisted Reproduction and Genetics. 35 (8): 1419–1429. doi:10.1007/s10815-018-1231-4. PMC 6086790. PMID 29968069.

Dopunska literatura[uredi | uredi izvor]

Verhage HG, Fazleabas AT, Donnelly K (1988). "The in vitro synthesis and release of proteins by the human oviduct". Endocrinology. 122 (4): 1639–45. doi:10.1210/endo-122-4-1639. PMID 3278893.
Iontcheva I, Oppenheim FG, Troxler RF (1997). "Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins". J. Dent. Res. 76 (3): 734–43. doi:10.1177/00220345970760030501. PMID 9109822. S2CID 39525421.
Iontcheva I, Oppenheim FG, Offner GD, Troxler RF (2000). "Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system". J. Dent. Res. 79 (2): 732–9. doi:10.1177/00220345000790020601. PMID 10728974. S2CID 27558675.
Agarwal A, Yeung WS, Lee KF (2002). "Cloning and characterization of the human oviduct-specific glycoprotein (HuOGP) gene promoter". Mol. Hum. Reprod. 8 (2): 167–75. doi:10.1093/molehr/8.2.167. PMID 11818519.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lok IH, Briton-Jones CM, Yuen PM, Haines CJ (2003). "Variable expression of oviductin mRNA at different stages of human reproductive cycle". J. Assist. Reprod. Genet. 19 (12): 569–76. doi:10.1023/A:1021263132176. PMC 3455833. PMID 12503889.
Chen Q, Zhang J, Sweet F (2004). "Homology of primate DNA fragments for estrous-associated oviductal glycoprotein". Hereditas. 139 (1): 75–9. doi:10.1111/j.1601-5223.2003.01640.x. PMID 14641477.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Woo MM, Alkushi A, Verhage HG, et al. (2005). "Gain of OGP, an estrogen-regulated oviduct-specific glycoprotein, is associated with the development of endometrial hyperplasia and endometrial cancer". Clin. Cancer Res. 10 (23): 7958–64. doi:10.1158/1078-0432.CCR-04-1261. PMID 15585630.
Ling L, Lee YL, Lee KF, et al. (2006). "Expression of human oviductin in an immortalized human oviductal cell line". Fertil. Steril. 84 Suppl 2: 1095–103. doi:10.1016/j.fertnstert.2005.06.006. PMID 16209999.
Kadam KM, D'Souza SJ, Bandivdekar AH, Natraj U (2006). "Identification and characterization of oviductal glycoprotein-binding protein partner on gametes: epitopic similarity to non-muscle myosin IIA, MYH 9". Mol. Hum. Reprod. 12 (4): 275–82. doi:10.1093/molehr/gal028. PMID 16567366.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000085465 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074340 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7819450-5] Arias EB, Verhage HG, Jaffe RC (Feb 1995). "Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein". Biol Reprod. 51 (4): 685–94. doi:10.1095/biolreprod51.4.685. PMID 7819450.

[pmid9341614-6] Lapensee L, Paquette Y, Bleau G (Nov 1997). "Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9)". Fertil Steril. 68 (4): 702–8. doi:10.1016/S0015-0282(97)00317-8. PMID 9341614.

[entrez-7] "Entrez Gene: OVGP1 oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)".

[UniProt-8] "UniProt, Q12889" (jezik: eng.). Pristupljeno 3. 12. 2021.CS1 održavanje: nepoznati jezik (link)

[9] Laheri, Saniya; Modi, Deepak; Bhatt, Purvi (Mar 2017). "Extra-oviductal expression of oviductal glycoprotein 1 in mouse: Detection in testis, epididymis and ovary". Journal of Biosciences. 42 (1): 69–80. doi:10.1007/s12038-016-9657-2. PMID 28229966. S2CID 10274575. Pristupljeno 16. 7. 2018.

[10] Laheri, Saniya; Ashary, Nancy; Bhatt, Purvi; Modi, Deepak (2018). "Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion". Journal of Assisted Reproduction and Genetics. 35 (8): 1419–1429. doi:10.1007/s10815-018-1231-4. PMC 6086790. PMID 29968069.

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