TCEAL1

TCEAL1
Identifikatori
Aliasi	TCEAL1
Vanjski ID-jevi	OMIM: 300237 MGI: 2385317 HomoloGene: 3510 GeneCards: TCEAL1
Lokacija gena (čovjek)
Hrom.	Hromosom X
Kraj	103,630,953 bp
Lokacija gena (miš)
Hrom.	Hromosom X (miš)
Kraj	135,612,227 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • WW domain binding;
Ćelijska komponenta	• jedro; • nukleoplazma;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • GO:1901227 negative regulation of transcription by RNA polymerase II; • transcription, DNA-templated;
	Izvori:Amigo / QuickGO
Ortolozi
	9338
	237052
	ENSG00000172465
	ENSMUSG00000049536
	Q15170
	Q921P9
	NM_004780; NM_001006639; NM_001006640
	NM_146236; NM_001356367
	NP_001006640; NP_001006641; NP_004771
	NP_666348; NP_001343296
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Proteinoliki-1 faktor A transcripcijske elongacije je protein koji je kod ljudi kodiran genom TCEAL1.^[5]^[6]^[7]

Ovaj gen kodira člana genetičke generacije slične faktoru elongacije transkripcije A (SII) (TCEAL). Članovi ove porodice mogu funkcionirati kao jedarni fosfoproteini, koji moduliraju transkripciju koja ovisana o kontekstu promotora. Kodirani protein sličan je faktoru elongacije transkripcijskog A faktora transkripcije SII i sadrži motiv sličan cinkovom prstu kao i sekvencu povezanu sa faktorom transkripcije SII Pol II-vezanja. Učinak može ispoljavati putem interakcije protein-protein sa drugim regulatorima transkripcije, a ne direktnim vezivanjem DNK. Više članova porodice nalazi se na X hromosomu. Alternativna prerada rezultira u više varijanti transkripta koji kodiraju jednu izoformu.^[7]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172465 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049536 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yeh CH, Shatkin AJ (Jul 1994). "A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII". Gene. 143 (2): 285–7. doi:10.1016/0378-1119(94)90112-0. PMID 8206389.
^ Yeh CH, Shatkin AJ (Dec 1994). "Down-regulation of Rous sarcoma virus long terminal repeat promoter activity by a HeLa cell basic protein". Proc Natl Acad Sci U S A. 91 (23): 11002–6. doi:10.1073/pnas.91.23.11002. PMC 45154. PMID 7971997.
^ ^a ^b "Entrez Gene: TCEAL1 transcription elongation factor A (SII)-like 1".

Dopunska literature[uredi | uredi izvor]

Yeh CH, Zong WX, Shatkin AJ (1995). "The Ser36-Ser37 pair in HeLa nuclear protein p21/SIIR mediates Ser/Thr phosphorylation and is essential for Rous sarcoma virus long terminal repeat repression". J. Biol. Chem. 270 (43): 25313–5. doi:10.1074/jbc.270.44.26558. PMID 7592688.
Pillutla RC, Shimamoto A, Furuichi Y, Shatkin AJ (1999). "Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR". Genomics. 56 (2): 217–20. doi:10.1006/geno.1998.5705. PMID 10051408.
van der Kuip H, Carius B, Haque SJ, et al. (1999). "The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins". J. Mol. Med. 77 (4): 386–92. doi:10.1007/s001090050365. PMID 10353443.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Makino H, Tajiri T, Miyashita M, et al. (2005). "Differential expression of TCEAL1 in esophageal cancers by custom cDNA microarray analysis". Dis. Esophagus. 18 (1): 37–40. doi:10.1111/j.1442-2050.2005.00432.x. PMID 15773840.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172465 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049536 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8206389-5] Yeh CH, Shatkin AJ (Jul 1994). "A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII". Gene. 143 (2): 285–7. doi:10.1016/0378-1119(94)90112-0. PMID 8206389.

[pmid7971997-6] Yeh CH, Shatkin AJ (Dec 1994). "Down-regulation of Rous sarcoma virus long terminal repeat promoter activity by a HeLa cell basic protein". Proc Natl Acad Sci U S A. 91 (23): 11002–6. doi:10.1073/pnas.91.23.11002. PMC 45154. PMID 7971997.

[entrez-7] "Entrez Gene: TCEAL1 transcription elongation factor A (SII)-like 1".

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