PDCD7
| PDCD7 | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||||||||||||||||
| Aliasi | PDCD7 | ||||||||||||||||||||||||
| Vanjski ID-jevi | OMIM: 608138 MGI: 1859170 HomoloGene: 4170 GeneCards: PDCD7 | ||||||||||||||||||||||||
| |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| Ortolozi | |||||||||||||||||||||||||
| Vrste | Čovjek | Miš | |||||||||||||||||||||||
| Entrez | |||||||||||||||||||||||||
| Ensembl | |||||||||||||||||||||||||
| UniProt | |||||||||||||||||||||||||
| RefSeq (mRNK) | |||||||||||||||||||||||||
| RefSeq (bjelančevina) |
| ||||||||||||||||||||||||
| Lokacija (UCSC) | Chr 15: 65.12 – 65.13 Mb | Chr 9: 65.25 – 65.27 Mb | |||||||||||||||||||||||
| PubMed pretraga | [3] | [4] | |||||||||||||||||||||||
| Wikipodaci | |||||||||||||||||||||||||
| |||||||||||||||||||||||||
Protein 7 programirane ćelijske smrti je protein koji je kod ljudi kodiran genom PDCD7.[5][6]
Ovaj gen kodira protein slične sekvence mišjeg proteina koji je izvorno identificiran u embrionskim matičnim ćelijaka. U mišjim T-ćelijskim linijama ovaj protein povezan je sa glukokortikoidima i apoptotskim putevima izazvanim staurinom i povezan sa keramid omposredovanom signalizacijom. Ova zapažanja sugeriraju da je ovaj genski proizvod uključen u specifične apoptozne procese u T-ćelijama.[6]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 485 aminokiselina, a molekulska težina 54.700 Da.[7].
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MALPPFFGQG | RPGPPPPQPP | PPAPFGCPPP | PLPSPAFPPP | LPQRPGPFPG | ||||
| ASAPFLQPPL | ALQPRASAEA | SRGGGGAGAF | YPVPPPPLPP | PPPQCRPFPG | ||||
| TDAGERPRPP | PPGPGPPWSP | RWPEAPPPPA | DVLGDAALQR | LRDRQWLEAV | ||||
| FGTPRRAGCP | VPQRTHAGPS | LGEVRARLLR | ALRLVRRLRG | LSQALREAEA | ||||
| DGAAWVLLYS | QTAPLRAELA | ERLQPLTQAA | YVGEARRRLE | RVRRRRLRLR | ||||
| ERAREREAER | EAEAARAVER | EQEIDRWRVK | CVQEVEEKKR | EQELKAAADG | ||||
| VLSEVRKKQA | DTKRMVDILR | ALEKLRKLRK | EAAARKGVCP | PASADETFTH | ||||
| HLQRLRKLIK | KRSELYEAEE | RALRVMLEGE | QEEERKRELE | KKQRKEKEKI | ||||
| LLQKREIESK | LFGDPDEFPL | AHLLEPFRQY | YLQAEHSLPA | LIQIRHDWDQ | ||||
| YLVPSDHPKG | NFVPQGWVLP | PLPSNDIWAT | AVKLH |
- Simboli
Reference
[uredi | uredi izvor]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000090470 - Ensembl, maj 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041837 - Ensembl, maj 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Park EJ, Kim JH, Seong RH, Kim CG, Park SD, Hong SH (Apr 1999). "Characterization of a novel mouse cDNA, ES18, involved in apoptotic cell death of T-cells". Nucleic Acids Res. 27 (6): 1524–30. doi:10.1093/nar/27.6.1524. PMC 148348. PMID 10037816.
- 1 2 "Entrez Gene: PDCD7 programmed cell death 7".
- ↑ "UniProt, Q8N8D1". Pristupljeno 16. 7. 2021.
Dopunska literatura
[uredi | uredi izvor]- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Vanjski linkovi
[uredi | uredi izvor]- PDCD7 lokacija ljudskog genoma UCSC Genome Browser.
PDCD7 detalji ljudskog genoma u UCSC Genome Browser.