PFDN6

PFDN6
Identifikatori
Aliasi	PFDN6
Vanjski ID-jevi	OMIM: 605660 MGI: 95908 HomoloGene: 40720 GeneCards: PFDN6
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	33,298,401 bp
Lokacija gena (miš)
Hrom.	Hromosom 17 (miš)
Kraj	34,159,317 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• unfolded protein binding; • chaperone binding;
Ćelijska komponenta	• citoplazma; • prefoldin complex;
Biološki proces	• chaperone-mediated protein complex assembly; • Savijanje proteina;
	Izvori:Amigo / QuickGO
Ortolozi
	10471
	14976
ENSG00000237335; ENSG00000204220; ENSG00000235692; ENSG00000206283; ENSG00000224782;
	n/a
	ENSMUSG00000024309
	O15212; Q5STK2
	Q03958
	NM_014260; NM_001185181; NM_001265595; NM_001265596
	NM_001185182; NM_010385
NP_001172110; NP_001252524; NP_001252525; NP_055075; NP_001172110.1;
	NP_001252524.1; NP_001252525.1; NP_055075.1
	NP_001172111; NP_034515
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Prefoldinska podjedinica 6 je protein koji je kod ljudi kodiran genom PFDN6 .^[5]^[6]^[7]

Biogeneza aktinskih i tubulinskih citoskeletnih proteina uključuje interakciju novonastalih lanaca svakog od dva proteina s oligomernim proteinom prefoldinom (PFD) i njihov naknadni prijenos u citosolni šaperonin CCT (šaperonin koji sadrži TCP-1). Elektronskom mikroskopijom pokazano je da eukariotski perfoldin, koji ima sličnu strukturu kao i njegov arhejski pandan, stupa u interakciju s rasklopljenim aktinom duž vrhova isturenih krakova. Čini se da aktin u svom stanju vezanom za PFD dobija konformaciju sličnu onoj usvojenoj kada je vezan za CCT. Trodimenzijska rekonstrukcija CCT: PFD kompleksa zasnovana na krioelektronskoj mikroskopiji otkriva da se PFD veže za svaki od CCT prstenova u jedinstvenoj konformaciji preko dvije specifične CCT podjedinice koje su smještene u 1,4 raspored. Ovo definira faziranje CCT prstenova i predlaže mehanizam primopredaje za PFD.^[8]

Reference[uredi | uredi izvor]

^ ^a ^b ^c ENSG00000204220, ENSG00000235692, ENSG00000206283, ENSG00000224782 GRCh38: Ensembl release 89: ENSG00000237335, ENSG00000204220, ENSG00000235692, ENSG00000206283, ENSG00000224782 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024309 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Herberg JA, Beck S, Trowsdale J (May 1998). "TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC". J Mol Biol. 277 (4): 839–57. doi:10.1006/jmbi.1998.1637. PMID 9545376.
^ Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ (Jul 1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell. 93 (5): 863–73. doi:10.1016/S0092-8674(00)81446-4. PMID 9630229. S2CID 16011829.
^ "Entrez Gene: PFDN6 prefoldin subunit 6".
^ Jaime Martín-Benito, Jasminka Boskovic, Paulino Gómez-Puertas, José L. Carrascosa, C.Torrey Simons,1 Sally A. Lewis,1 Francesca Bartolini,1 Nicholas J. Cowan,1 and José M. Valpuesta2 (2002): Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT. EMBO J. 21(23): 6377–6386. pmcid: pmc136944; pmid: 12456645 ;doi: 10.1093/emboj/cdf640

Dopunska literatura[uredi | uredi izvor]

Herberg JA, Sgouros J, Jones T, et al. (1998). "Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC". Eur. J. Immunol. 28 (2): 459–67. doi:10.1002/(SICI)1521-4141(199802)28:02<459::AID-IMMU459>3.0.CO;2-Z. PMID 9521053.</ref>*Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Simons CT, Staes A, Rommelaere H, et al. (2004). "Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding". J. Biol. Chem. 279 (6): 4196–203. doi:10.1074/jbc.M306053200. PMID 14634002.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ostrov DA, Barnes CL, Smith LE, et al. (2007). "Characterization of HKE2: an ancient antigen encoded in the major histocompatibility complex". Tissue Antigens. 69 (2): 181–8. doi:10.1111/j.1399-0039.2006.00730.x. PMID 17257322.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[refGRCh38Ensembl-1] ENSG00000204220, ENSG00000235692, ENSG00000206283, ENSG00000224782 GRCh38: Ensembl release 89: ENSG00000237335, ENSG00000204220, ENSG00000235692, ENSG00000206283, ENSG00000224782 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024309 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9545376-5] Herberg JA, Beck S, Trowsdale J (May 1998). "TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC". J Mol Biol. 277 (4): 839–57. doi:10.1006/jmbi.1998.1637. PMID 9545376.

[pmid9630229-6] Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ (Jul 1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell. 93 (5): 863–73. doi:10.1016/S0092-8674(00)81446-4. PMID 9630229. S2CID 16011829.

[entrez-7] "Entrez Gene: PFDN6 prefoldin subunit 6".

[8] Jaime Martín-Benito, Jasminka Boskovic, Paulino Gómez-Puertas, José L. Carrascosa, C.Torrey Simons,1 Sally A. Lewis,1 Francesca Bartolini,1 Nicholas J. Cowan,1 and José M. Valpuesta2 (2002): Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT. EMBO J. 21(23): 6377–6386. pmcid: pmc136944; pmid: 12456645 ;doi: 10.1093/emboj/cdf640

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