PHTF2

PHTF2
Identifikatori
Aliasi	PHTF2
Vanjski ID-jevi	OMIM: 616785 MGI: 1916020 HomoloGene: 10713 GeneCards: PHTF2
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	77,957,503 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	20,882,124 bp
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK;
Ćelijska komponenta	• Endoplazmatski retikulum; • jedro;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated;
	Izvori:Amigo / QuickGO
Ortolozi
	57157
	68770
	ENSG00000006576
	ENSMUSG00000039987
	Q8N3S3
	Q8CB19
NM_001127357; NM_001127358; NM_001127359; NM_001127360; NM_020432;
	NM_001366081; NM_001366082; NM_001366083; NM_001366084; NM_001366085; NM_001366086; NM_001366087; NM_001366088; NM_001366089; NM_001395270; NM_001395271; NM_001395272
	NM_172992
NP_001120829; NP_001120830; NP_001120831; NP_001120832; NP_065165;
	NP_001353010; NP_001353011; NP_001353012; NP_001353013; NP_001353014; NP_001353015; NP_001353016; NP_001353017; NP_001353018
	NP_766580
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Pretpostavljeni homeodomenski transkripcijski faktor 2 je protein koji je kod ljudi kodiran genom PHTF2.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 785 aminokiselina, а molekulska težina 88.757 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MASKVTDAIV	WYQKKEFLSV	ATTAPGPQQV	LPGYCQCSLK	DQGLFIQCLI
GAYDQQIWEK	SVEQREIKFI	KLGLRNKPKK	TAHVKPDLID	VDLVRGSAFA
KAKPESPWTS	LTRKGIVRVV	FFPFFFRWWL	QVTSKVIFFW	LLVLYLLQVA
AIVLFCSTSS	PHSIPLTEVI	GPIWLMLLLG	TVHCQIVSTR	TPKPPLSTGG
KRRRKLRKAA	HLEVHREGDG	SSTTDNTQEG	AVQNHGTSTS	HSVGTVFRDL
WHAAFFLSGS	KKAKNSIDKS	TETDNGYVSL	DGKKTVKSGE	DGIQNHEPQC
ETIRPEETAW	NTGTLRNGPS	KDTQRTITNV	SDEVSSEEGP	ETGYSLRRHV
DRTSEGVLRN	RKSHHYKKHY	PNEDAPKSGT	SCSSRCSSSR	QDSESARPES
ETEDVLWEDL	LHCAECHSSC	TSETDVENHQ	INPCVKKEYR	DDPFHQSHLP
WLHSSHPGLE	KISAIVWEGN	DCKKADMSVL	EISGMIMNRV	NSHIPGIGYQ
IFGNAVSLIL	GLTPFVFRLS	QATDLEQLTA	HSASELYVIA	FGSNEDVIVL
SMVIISFVVR	VSLVWIFFFL	LCVAERTYKQ	RLLFAKLFGH	LTSARRARKS
EVPHFRLKKV	QNIKMWLSLR	SYLKRRGPQR	SVDVIVSSAF	LLTISVVFIC
CAQLLHVHEI	FLDCHYNWEL	VIWCISLTLF	LLRFVTLGSE	TSKKYSNTSI
LLTEQINLYL	KMEKKPNKKE	ELTLVNNVLK	LATKLLKELD	SPFRLYGLTM
NPLLYNITQV	VILSAVSGVI	SDLLGFNLKL	WKIKS

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000006576 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039987 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Manuel A, Beaupain D, Romeo PH, Raich N (maj 2000). "Molecular characterization of a novel gene family (PHTF) conserved from Drosophila to mammals". Genomics. 64 (2): 216–20. doi:10.1006/geno.1999.6079. PMID 10729229.
^ "Entrez Gene: PHTF2 putative homeodomain transcription factor 2".
^ "UniProt, Q8N3S3" (jezik: engleski). Pristupljeno 28. 9. 2021.

Dopunska literatura[uredi | uredi izvor]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000006576 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039987 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10729229-5] Manuel A, Beaupain D, Romeo PH, Raich N (maj 2000). "Molecular characterization of a novel gene family (PHTF) conserved from Drosophila to mammals". Genomics. 64 (2): 216–20. doi:10.1006/geno.1999.6079. PMID 10729229.

[entrez-6] "Entrez Gene: PHTF2 putative homeodomain transcription factor 2".

[UniProt-7] "UniProt, Q8N3S3" (jezik: engleski). Pristupljeno 28. 9. 2021.

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