PI4K2B
Fosfatidilinozitolna 4-kinaza tip 2-beta jest enzim koji je kod ljudi kodiran genom PI4K2B sa hromosoma 4.[5][6]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 481 aminokiselina, а molekulska težina 54.744 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MEDPSEPDRL | ASADGGSPEE | EEDGEREPLL | PRIAWAHPRR | GAPGSAVRLL | ||||
| DAAGEEGEAG | DEELPLPPGD | VGVSRSSSAE | LDRSRPAVSV | TIGTSEMNAF | ||||
| LDDPEFADIM | LRAEQAIEVG | IFPERISQGS | SGSYFVKDPK | RKIIGVFKPK | ||||
| SEEPYGQLNP | KWTKYVHKVC | CPCCFGRGCL | IPNQGYLSEA | GAYLVDNKLH | ||||
| LSIVPKTKVV | WLVSETFNYN | AIDRAKSRGK | KYALEKVPKV | GRKFHRIGLP | ||||
| PKIGSFQLFV | EGYKEAEYWL | RKFEADPLPE | NIRKQFQSQF | ERLVILDYII | ||||
| RNTDRGNDNW | LVRYEKQKCE | KEIDHKESKW | IDDEEFLIKI | AAIDNGLAFP | ||||
| FKHPDEWRAY | PFHWAWLPQA | KVPFSEEIRN | LILPYISDMN | FVQDLCEDLY | ||||
| ELFKTDKGFD | KATFESQMSV | MRGQILNLTQ | ALRDGKSPFQ | LVQIPCVIVE | ||||
| RSQGGSQGRI | VHLSNSFTQT | VNCRKPFFSS | W |
Reference
[uredi | uredi izvor]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000038210 - Ensembl, maj 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029186 - Ensembl, maj 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Balla A, Tuymetova G, Barshishat M, Geiszt M, Balla T (maj 2002). "Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments". J Biol Chem. 277 (22): 20041–50. doi:10.1074/jbc.M111807200. PMID 11923287.
- ↑ "Entrez Gene: PI4K2B phosphatidylinositol 4-kinase type 2 beta". Arhivirano s originala, 4. 11. 2021. Pristupljeno 30. 10. 2021.
- ↑ "UniProt, Q8TCG2" (jezik: engleski). Pristupljeno 30. 10. 2021.
Dopunska literatura
[uredi | uredi izvor]- Griffioen M, van der Meijden ED, Slager EH, et al. (2008). "Identification of phosphatidylinositol 4-kinase type II beta as HLA class II-restricted target in graft versus leukemia reactivity". Proc. Natl. Acad. Sci. U.S.A. 105 (10): 3837–42. doi:10.1073/pnas.0712250105. PMC 2268788. PMID 18316730.
- Jones DR, Bultsma Y, Keune WJ, et al. (2006). "Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta". Mol. Cell. 23 (5): 685–95. doi:10.1016/j.molcel.2006.07.014. PMID 16949365.
- Srivastava R, Sinha RK, Subrahmanyam G (2006). "Type II phosphatidylinositol 4-kinase beta associates with TCR-CD3 zeta chain in Jurkat cells". Mol. Immunol. 43 (5): 454–63. doi:10.1016/j.molimm.2005.03.009. PMID 16337488.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wei YJ, Sun HQ, Yamamoto M, et al. (2003). "Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP". J. Biol. Chem. 277 (48): 46586–93. doi:10.1074/jbc.M206860200. PMID 12324459.
- Mora S, Durham PL, Smith JR, et al. (2002). "NCS-1 inhibits insulin-stimulated GLUT4 translocation in 3T3L1 adipocytes through a phosphatidylinositol 4-kinase-dependent pathway". J. Biol. Chem. 277 (30): 27494–500. doi:10.1074/jbc.M203669200. PMID 12011096.
- Huang C, Handlogten ME, Miller RT (2002). "Parallel activation of phosphatidylinositol 4-kinase and phospholipase C by the extracellular calcium-sensing receptor". J. Biol. Chem. 277 (23): 20293–300. doi:10.1074/jbc.M200831200. PMID 11907035.