PISD

PISD
Identifikatori
Aliasi	PISD
Vanjski ID-jevi	OMIM: 612770 MGI: 2445114 HomoloGene: 81653 GeneCards: PISD
Lokacija gena (čovjek)
Hrom.	Hromosom 22 (čovjek)
Kraj	31,662,221 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	32,942,990 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• carboxy-lyase activity; • lyase activity; • phosphatidylserine decarboxylase activity;
Ćelijska komponenta	• integral component of membrane; • mitochondrial inner membrane; • membrana; • mitohondrija; • jedro; • integral component of mitochondrial inner membrane;
Biološki proces	• lipid metabolism; • phospholipid biosynthetic process; • phosphatidylethanolamine biosynthetic process; • protein autoprocessing;
	Izvori:Amigo / QuickGO
Ortolozi
	23761
	320951
	ENSG00000241878
	ENSMUSG00000023452
	Q9UG56
	Q8BSF4
NM_014338; NM_001326411; NM_001326412; NM_001326413; NM_001326414;
	NM_001326415; NM_001326416; NM_001326417; NM_001326418; NM_001326419; NM_001326420; NM_001326421; NM_178022
	NM_177298; NM_001347332
NP_001313340; NP_001313341; NP_001313342; NP_001313343; NP_001313344;
	NP_001313345; NP_001313346; NP_001313347; NP_001313348; NP_001313349; NP_001313350; NP_055153; NP_821141
	NP_001334261; NP_796272
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Proenzim fosfatiduilserin-dekarboksilaza jest enzim koji je kod ljudi kodiran genom PISD sa hromosoma 22.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 409 aminokiselina, a molekulska težina 46.672 Da^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MATSVGHRCL	GLLHGVAPWR	SSLHPCEITA	LSQSLQPLRK	LPFRAFRTDA
RKIHTAPART	MFLLRPLPIL	LVTGGGYAGY	RQYEKYRERE	LEKLGLEIPP
KLAGHWEVAL	YKSVPTRLLS	RAWGRLNQVE	LPHWLRRPVY	SLYIWTFGVN
MKEAAVEDLH	HYRNLSEFFR	RKLKPQARPV	CGLHSVISPS	DGRILNFGQV
KNCEVEQVKG	VTYSLESFLG	PRMCTEDLPF	PPAASCDSFK	NQLVTREGNE
LYHCVIYLAP	GDYHCFHSPT	DWTVSHRRHF	PGSLMSVNPG	MARWIKELFC
HNERVVLTGD	WKHGFFSLTA	VGATNVGSIR	IYFDRDLHTN	SPRHSKGSYN
DFSFVTHTNR	EGVPMRKGEH	LGEFNLGSTI	VLIFEAPKDF	NFQLKTGQKI
RFGEALGSL

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000241878 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023452 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
^ ^a ^b "Entrez Gene: PISD phosphatidylserine decarboxylase".

Dopunska literatura[uredi | uredi izvor]

Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Kuge O, Saito K, Kojima M, Akamatsu Y, Nishijima M (1996). "Post-translational processing of the phosphatidylserine decarboxylase gene product in Chinese hamster ovary cells". Biochem. J. 319 ( Pt 1) (Pt 1): 33–8. PMC 1217732. PMID 8870646.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Cheng J, Kapranov P, Drenkow J, Dike S, Brubaker S, Patel S, Long J, Stern D, Tammana H, Helt G, Sementchenko V, Piccolboni A, Bekiranov S, Bailey DK, Ganesh M, Ghosh S, Bell I, Gerhard DS, Gingeras TR (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. doi:10.1126/science.1108625. PMID 15790807.
Steenbergen R, Nanowski TS, Beigneux A, Kulinski A, Young SG, Vance JE (2006). "Disruption of the Phosphatidylserine Decarboxylase Gene in Mice Causes Embryonic Lethality and Mitochondrial Defects". J. Biol. Chem. 280 (48): 40032–40. doi:10.1074/jbc.M506510200. PMC 2888304. PMID 16192276.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Forbes CD, Toth JG, Ozbal CC, Lamarr WA, Pendleton JA, Rocks S, Gedrich RW, Osterman DG, Landro JA, Lumb KJ (2007). "High-throughput mass spectrometry screening for inhibitors of phosphatidylserine decarboxylase". Journal of Biomolecular Screening. 12 (5): 628–34. doi:10.1177/1087057107301320. PMID 17478478.

Vanjski linkovi[uredi | uredi izvor]

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000241878 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023452 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10591208-5] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.

[entrez-6] "Entrez Gene: PISD phosphatidylserine decarboxylase".

[1]

[2]

[3]

[4]

[5]

[6]

p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak