PKIG
Gama inhibitor cAMP-ovisne proteina-kinaze je protein kiji je kod ljudi kodiran genom PKIG.[5][6]
Protein kodiran ovim genom član je porodice inhibitora ovisne o cAMP protein-kinazama (PKA). Studije sličnih proteina na miševima sugeriraju da ovaj protein djeluje kao snažni kompetitivni inhibitor PKA i da je prevladavajući oblik inhibitora PKA u različitim tkivima. Prijavljene su tri alternativno prerađene varijante transkripta koji kodiraju isti protein.[6]
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000168734 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035268 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Zheng L, Yu L, Tu Q, Zhang M, He H, Chen W, Gao J, Yu J, Wu Q, Zhao S (Jan 2001). "Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA". Biochem J. 349 (Pt 2): 403–7. doi:10.1042/0264-6021:3490403. PMC 1221161. PMID 10880337.
- ^ a b "Entrez Gene: PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma".
Dopunska literatura[uredi | uredi izvor]
- Collins SP, Uhler MD (1997). "Characterization of PKIgamma, a novel isoform of the protein kinase inhibitor of cAMP-dependent protein kinase". J. Biol. Chem. 272 (29): 18169–78. doi:10.1074/jbc.272.29.18169. PMID 9218452.
- Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics. 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
- Lum H, Hao Z, Gayle D, et al. (2002). "Vascular endothelial cells express isoforms of protein kinase A inhibitor". Am. J. Physiol., Cell Physiol. 282 (1): C59–66. doi:10.1152/ajpcell.00256.2001. PMID 11742798.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Yu J, Yu L, Chen Z, et al. (2002). "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors". Brain Res. Mol. Brain Res. 99 (2): 145–9. doi:10.1016/S0169-328X(02)00104-3. PMID 11978406.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Zhao L, Yang S, Zhou GQ, et al. (2006). "Downregulation of cAMP-dependent protein kinase inhibitor gamma is required for BMP-2-induced osteoblastic differentiation". Int. J. Biochem. Cell Biol. 38 (12): 2064–73. doi:10.1016/j.biocel.2006.05.015. PMID 16870489.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.