PLAA

PLAA
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2K89, 2K8A, 2K8B, 2K8C, 3EBB
Identifikatori
Aliasi	PLAA
Vanjski ID-jevi	OMIM: 603873 MGI: 104810 HomoloGene: 3138 GeneCards: PLAA
Lokacija gena (čovjek)
Hrom.	Hromosom 9 (čovjek)
Kraj	26,947,242 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	94,491,481 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • phospholipase A2 activator activity; • ubiquitin binding;
Ćelijska komponenta	• Egzosom; • citoplazma; • jedro; • sinapsa; • međućelijske veze;
Biološki proces	• phospholipid metabolic process; • inflammatory response; • GO:0072468 Transdukcija signala; • ubiquitin recycling; • proteasome-mediated ubiquitin-dependent protein catabolic process; • macroautophagy; • ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; • cellular response to lipopolysaccharide; • negative regulation of protein K63-linked ubiquitination; • positive regulation of synaptic vesicle recycling; • positive regulation of dendrite extension; • positive regulation of neuron migration; • prostaglandin metabolic process; • multicellular organism development; • nervous system development; • positive regulation of phospholipase A2 activity;
	Izvori:Amigo / QuickGO
Ortolozi
	9373
	18786
	ENSG00000137055
	ENSMUSG00000028577
	Q9Y263
	P27612
	NM_001031689; NM_004253; NM_001321546
	NM_172695
	NP_001026859; NP_001308475
	NP_766283
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Fosfolipazno A-2-aktivirajući protein je enzim koji je kod ljudi kodiran genom PLAA.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 795 aminokiselina, а molekulska težina 87.157 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MTSGATRYRL	SCSLRGHELD	VRGLVCCAYP	PGAFVSVSRD	RTTRLWAPDS
PNRSFTEMHC	MSGHSNFVSC	VCIIPSSDIY	PHGLIATGGN	DHNICIFSLD
SPMPLYILKG	HKNTVCSLSS	GKFGTLLSGS	WDTTAKVWLN	DKCMMTLQGH
TAAVWAVKIL	PEQGLMLTGS	ADKTVKLWKA	GRCERTFSGH	EDCVRGLAIL
SETEFLSCAN	DASIRRWQIT	GECLEVYYGH	TNYIYSISVF	PNCRDFVTTA
EDRSLRIWKH	GECAQTIRLP	AQSIWCCCVL	DNGDIVVGAS	DGIIRVFTES
EDRTASAEEI	KAFEKELSHA	TIDSKTGDLG	DINAEQLPGR	EHLNEPGTRE
GQTRLIRDGE	KVEAYQWSVS	EGRWIKIGDV	VGSSGANQQT	SGKVLYEGKE
FDYVFSIDVN	EGGPSYKLPY	NTSDDPWLTA	YNFLQKNDLN	PMFLDQVAKF
IIDNTKGQML	GLGNPSFSDP	FTGGGRYVPG	SSGSSNTLPT	ADPFTGAGRY
VPGSASMGTT	MAGVDPFTGN	SAYRSAASKT	MNIYFPKKEA	VTFDQANPTQ
ILGKLKELNG	TAPEEKKLTE	DDLILLEKIL	SLICNSSSEK	PTVQQLQILW
KAINCPEDIV	FPALDILRLS	IKHPSVNENF	CNEKEGAQFS	SHLINLLNPK
GKPANQLLAL	RTFCNCFVGQ	AGQKLMMSQR	ESLMSHAIEL	KSGSNKNIHI
ALATLALNYS	VCFHKDHNIE	GKAQCLSLIS	TILEVVQDLE	ATFRLLVALG
TLISDDSNAV	QLAKSLGVDS	QIKKYSSVSE	PAKVSECCRF	ILNLL

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137055 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028577 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chopra AK, Ribardo DA, Wood TG, Prusak DJ, Xu XJ, Peterson JW (Mar 1999). "Molecular characterization of cDNA for phospholipase A2-activating protein". Biochim Biophys Acta. 1444 (1): 125–30. doi:10.1016/s0167-4781(98)00249-8. PMID 9931468.
^ Beatty BG, Qi S, Pienkowska M, Herbrick JA, Scheidl T, Zhang ZM, Kola I, Scherer SW, Seth A (Mar 2000). "Chromosomal localization of phospholipase A2 activating protein, an Ets2 target gene, to 9p21". Genomics. 62 (3): 529–32. doi:10.1006/geno.1999.5999. PMID 10644453.
^ "Entrez Gene: PLAA phospholipase A2-activating protein".
^ "UniProt, Q9Y263". Pristupljeno 11. 9. 2021.

Dopunska literatura[uredi | uredi izvor]

Clark MA, Ozgür LE, Conway TM, et al. (1991). "Cloning of a phospholipase A2-activating protein". Proc. Natl. Acad. Sci. U.S.A. 88 (12): 5418–22. Bibcode:1991PNAS...88.5418C. doi:10.1073/pnas.88.12.5418. PMC 51884. PMID 2052621.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Ruiz A, Nadal M, Puig S, Estivill X (1999). "Cloning of the human phospholipase A2 activating protein (hPLAP) gene on the chromosome 9p21 melanoma deleted region". Gene. 239 (1): 155–61. doi:10.1016/S0378-1119(99)00354-6. PMID 10571045.
Seigneurin-Berny D, Verdel A, Curtet S, et al. (2001). "Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways". Mol. Cell. Biol. 21 (23): 8035–44. doi:10.1128/MCB.21.23.8035-8044.2001. PMC 99970. PMID 11689694.
Kozlenkov A, Manes T, Hoylaerts MF, Millán JL (2002). "Function assignment to conserved residues in mammalian alkaline phosphatases". J. Biol. Chem. 277 (25): 22992–9. doi:10.1074/jbc.M202298200. PMID 11937510.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Koumanov K, Momchilova A, Wolf C (2004). "Bimodal regulatory effect of melittin and phospholipase A2-activating protein on human type II secretory phospholipase A2". Cell Biol. Int. 27 (10): 871–7. doi:10.1016/S1065-6995(03)00176-8. PMID 14499668. S2CID 10953531.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Vanjski linkovi[uredi | uredi izvor]

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137055 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028577 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9931468-5] Chopra AK, Ribardo DA, Wood TG, Prusak DJ, Xu XJ, Peterson JW (Mar 1999). "Molecular characterization of cDNA for phospholipase A2-activating protein". Biochim Biophys Acta. 1444 (1): 125–30. doi:10.1016/s0167-4781(98)00249-8. PMID 9931468.

[pmid10644453-6] Beatty BG, Qi S, Pienkowska M, Herbrick JA, Scheidl T, Zhang ZM, Kola I, Scherer SW, Seth A (Mar 2000). "Chromosomal localization of phospholipase A2 activating protein, an Ets2 target gene, to 9p21". Genomics. 62 (3): 529–32. doi:10.1006/geno.1999.5999. PMID 10644453.

[entrez-7] "Entrez Gene: PLAA phospholipase A2-activating protein".

[UniProt-8] "UniProt, Q9Y263". Pristupljeno 11. 9. 2021.

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p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak