S Wikipedije, slobodne enciklopedije
Nekodirajući onkogen Pvt1PVT1 ili plazmacitomna varijanta translokacije 1 je gen dugolančane nekodirajuće RNK .[ 3]
Kod miševa , ovaj gen je identificiran kao mjesto loma u hromosomu 6; translokacije u hromosomu 15. Ove translokacije su povezane sa mišjim plazmacitomima . [ 4] htomosomu 8 , koja je povezana s rijetkom varijantom Burkittovog limfoma .[ 5] pacova , pokazalo se da je ova tačka prekida uobičajeno mjesto provirusna integracijska u retrovirusnim induciranim T-limfomima .[ 6] Transkripciju PVT1 regulira Myc .[ 7]
Prekomjerna ekspresija PVT1 može dovesti do tumorigeneze na tri načina. Preuređivanje fuzijomDNK PVT1 i onkogenskog tumorskog supresora moglo bi dovesti do disregulacije onkogena ili supresije tumora , što je na kraju dovodi do tumorigeneze. Zatim, ekspresija miRNK kodiranih putem PVT1 može smanjiti regulaciju gena za suzbijanje tumora, uzrokujući tumorigenezu. Konačno, povećanje interakcije MYC s PVT1 može takođđer dovesti do tumorigeneze.[ 8]
Nadekspresija PVT1 koji se nalazi u regiji 8q24.21 povezana je s mnogim tipovima raka kod ljudi [ 8] raku prostate snižava ekspresiju gena miR-146a , što dovodi do smanjenja nivoa miR-146a u ćeliji , putem metilacija CpG-otoka na promotorskoj regiji, podstičući suzbijanje ćelija raka apoptozom .[ 9] mikroRNK utiče na otpornost na hemoterapiju u više tipova raka epigenetičkom regulacijom ili direktnom represijom drugih nekodiranih transkripata.[ 10]
^ a b c GRCh38: Ensembl release 89: ENSG00000249859 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: PVT1 Pvt1 oncogene homolog, MYC activator (mouse)" .^ Cory S, Graham M, Webb E, Corcoran L, Adams JM (March 1985). "Variant (6;15) translocations in murine plasmacytomas involve a chromosome 15 locus at least 72 kb from the c-myc oncogene" . The EMBO Journal . 4 (3): 675–681. doi :10.1002/j.1460-2075.1985.tb03682.x . PMC 554241 PMID 3924592 . ^ Graham M, Adams JM (November 1986). "Chromosome 8 breakpoint far 3′ of the c-myc oncogene in a Burkitt's lymphoma 2;8 variant translocation is equivalent to the murine pvt-1 locus" . The EMBO Journal . 5 (11): 2845–2851. doi :10.1002/j.1460-2075.1986.tb04578.x . PMC 1167233 PMID 3024964 . ^ Villeneuve L, Rassart E, Jolicoeur P, Graham M, Adams JM (May 1986). "Proviral integration site Mis-1 in rat thymomas corresponds to the pvt-1 translocation breakpoint in murine plasmacytomas" . Molecular and Cellular Biology . 6 (5): 1834–1837. doi :10.1128/MCB.6.5.1834 . PMC 367714 PMID 3785181 . ^ Carramusa L, Contino F, Ferro A, Minafra L, Perconti G, Giallongo A, Feo S (November 2007). "The PVT-1 oncogene is a MYC protein target that is overexpressed in transformed cells" . Journal of Cellular Physiology . 213 (2): 511–518. doi :10.1002/jcp.21133 PMID 17503467 . ^ a b Cui M, You L, Ren X, Zhao W, Liao Q, Zhao Y (February 2016). "Long non-coding RNA PVT1 and cancer". Biochemical and Biophysical Research Communications . 471 (1): 10–14. doi :10.1016/j.bbrc.2015.12.101 . PMID 26850852 . ^ Liu HT, Fang L, Cheng YX, Sun Q (December 2016). "LncRNA PVT1 regulates prostate cancer cell growth by inducing the methylation of miR-146a" . Cancer Medicine . 5 (12): 3512–3519. doi :10.1002/cam4.900 . PMC 5224852 PMID 27794184 . ^ Ogunwobi OO, Kumar A (August 2019). "Chemoresistance Mediated by ceRNA Networks Associated With the PVT1 Locus" . Frontiers in Oncology . 9 (1): 834. doi :10.3389/fonc.2019.00834 PMC 6718704 PMID 31508377 .
Guan Y, Kuo WL, Stilwell JL, Takano H, Lapuk AV, Fridlyand J, Mao JH, Yu M, Miller MA, Santos JL, Kalloger SE, Carlson JW, Ginzinger DG, Celniker SE, Mills GB, Huntsman DG, Gray JW (October 2007). "Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer" . Clinical Cancer Research . 13 (19): 5745–5755. doi :10.1158/1078-0432.CCR-06-2882 PMID 17908964 . Millis MP, Bowen D, Kingsley C, Watanabe RM, Wolford JK (December 2007). "Variants in the plasmacytoma variant translocation gene (PVT1) are associated with end-stage renal disease attributed to type 1 diabetes" . Diabetes . 56 (12): 3027–3032. doi :10.2337/db07-0675 PMID 17881614 . Carramusa L, Contino F, Ferro A, Minafra L, Perconti G, Giallongo A, Feo S (November 2007). "The PVT-1 oncogene is a Myc protein target that is overexpressed in transformed cells" . Journal of Cellular Physiology . 213 (2): 511–518. doi :10.1002/jcp.21133 PMID 17503467 . Hanson RL, Craig DW, Millis MP, Yeatts KA, Kobes S, Pearson JV, Lee AM, Knowler WC, Nelson RG, Wolford JK (April 2007). "Identification of PVT1 as a candidate gene for end-stage renal disease in type 2 diabetes using a pooling-based genome-wide single nucleotide polymorphism association study" . Diabetes . 56 (4): 975–983. doi :10.2337/db06-1072 PMID 17395743 . Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (December 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome . 16 (12): 942–954. doi :10.1007/s00335-005-0075-2 . PMID 16341674 . S2CID 69278 . Graham M, Adams JM (November 1986). "Chromosome 8 breakpoint far 3′ of the c-myc oncogene in a Burkitt's lymphoma 2;8 variant translocation is equivalent to the murine pvt-1 locus" . The EMBO Journal . 5 (11): 2845–2851. doi :10.1002/j.1460-2075.1986.tb04578.x . PMC 1167233 PMID 3024964 . Shtivelman E, Bishop JM (March 1989). "The PVT gene frequently amplifies with MYC in tumor cells" . Molecular and Cellular Biology . 9 (3): 1148–1154. doi :10.1128/MCB.9.3.1148 . PMC 362705 PMID 2725491 . Shtivelman E, Henglein B, Groitl P, Lipp M, Bishop JM (May 1989). "Identification of a human transcription unit affected by the variant chromosomal translocations 2;8 and 8;22 of Burkitt lymphoma" . Proceedings of the National Academy of Sciences of the United States of America . 86 (9): 3257–3260. Bibcode :1989PNAS...86.3257S . doi :10.1073/pnas.86.9.3257 PMC 287109 PMID 2470097 . Shtivelman E, Bishop JM (April 1990). "Effects of translocations on transcription from PVT" . Molecular and Cellular Biology . 10 (4): 1835–1839. doi :10.1128/MCB.10.4.1835 . PMC 362296 PMID 2181290 . 
