PRR5L

PRR5L
Identifikatori
Aliasi	PRR5L
Vanjski ID-jevi	OMIM: 611728 MGI: 1919696 HomoloGene: 11753 GeneCards: PRR5L
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek) Bend 11p13-p12 Početak 36,296,288 bp Kraj 36,465,204 bp
Lokacija gena (miš) Hrom. Hromosom 2 (miš) Bend 2|2 E2 Početak 101,544,630 bp Kraj 101,713,372 bp
Ontologija gena Molekularna funkcija • ubiquitin protein ligase binding • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • TORC2 complex Biološki proces • TORC2 signaling • GO:0033128 negative regulation of protein phosphorylation • positive regulation of phosphatidylinositol 3-kinase signaling • negative regulation of signal transduction • positive regulation of protein phosphorylation • regulation of fibroblast migration • cellular response to oxidative stress • positive regulation of mRNA catabolic process • positive regulation of intracellular protein transport Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	79899	72446
Ensembl	ENSG00000135362	ENSMUSG00000032841
UniProt	Q6MZQ0	A2AVJ5
RefSeq (mRNK)	NM_024841 NM_001160167 NM_001160168 NM_001160169	NM_001083810 NM_001110849 NM_175181 NM_001355625
RefSeq (bjelančevina)	NP_001153639 NP_001153640 NP_001153641 NP_079117	NP_001077279 NP_001104319 NP_780390 NP_001342554
Lokacija (UCSC)	Chr 11: 36.3 – 36.47 Mb	Chr 2: 101.54 – 101.71 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Prolinom bogati protein 5 je protein koji je kod ljudi kodiran genom PRR5L.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 368 aminokiselina, a molekulska težina 40.836 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MTRGFAPILP		VEFHKMGSFR		RPRPRFMSSP		VLSDLPRFQA		ARQALQLSSS
SAWNSVQTAV		INVFKGGGLQ		SNELYALNEN		IRRLLKSELG		SFITDYFQNQ
LLAKGLFFVE		EKIKLCEGEN		RIEVLAEVWD		HFFTETLPTL		QAIFYPVQGQ
ELTIRQISLL		GFRDLVLLKV		KLGDLLLLAQ		SKLPSSIVQM		LLILQSVHEP
TGPSESYLQL		EELVKQVVSP		FLGISGDRSF		SGPTYTLARR		HSRVRPKVTV
LNYASPITAV		SRPLNEMVLT		PLTEQEGEAY		LEKCGSVRRH		TVANAHSDIQ
LLAMATMMHS		GLGEEASSEN		KCLLLPPSFP		PPHRQCSSEP		NITDNPDGLE
EGARGSQEGS		ELNCASLS

Dopunska literatura

• Pearce LR, Huang X, Boudeau J, Pawłowski R, Wullschleger S, Deak M, Ibrahim AF, Gourlay R, Magnuson MA, Alessi DR (2007). "Identification of Protor as a novel Rictor-binding component of mTOR complex-2". Biochem. J. 405 (3): 513–22. doi:10.1042/BJ20070540. PMC 2267312. PMID 17461779.
• Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression". PLOS ONE. 5 (9): e12862. Bibcode:2010PLoSO...512862H. doi:10.1371/journal.pone.0012862. PMC 2943476. PMID 20877624.