RASSF5

RASSF5
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4LGD, 4OH8
Identifikatori
Aliasi	RASSF5
Vanjski ID-jevi	OMIM: 607020 MGI: 1926375 HomoloGene: 10296 GeneCards: RASSF5
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	206,589,448 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	131,172,995 bp
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje iona metala; • vezivanje identičnih proteina;
Ćelijska komponenta	• citoplazma; • Mikrotubula; • citoskelet; • jedro;
Biološki proces	• GO:0007243 intracellular signal transduction; • positive regulation of protein ubiquitination; • GO:0072468 Transdukcija signala; • negative regulation of cell population proliferation; • regulation of protein localization to nucleus; • GO:0097285 apoptoza; • regulation of apoptotic process;
	Izvori:Amigo / QuickGO
Ortolozi
	83593
	54354
	ENSG00000266094
	ENSMUSG00000026430
	Q8WWW0
	Q5EBH1
	NM_182665; NM_031437; NM_182663; NM_182664
	NM_018750; NM_001311094; NM_001313731
	NP_872604; NP_872605; NP_872606
	NP_001298023; NP_001300660; NP_061220
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Ras-pridruženi protein 5 sa domenom jest protein koji je kod ljudi kodiran genom RASSF5 ili F5 sa hromosoma 1.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 418 aminokiselina, a molekulska težina 47.090 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAMASPAIGQ	RPYPLLLDPE	PPRYLQSLSG	PELPPPPPDR	SSRLCVPAPL
STAPGAREGR	SARRAARGNL	EPPPRASRPA	RPLRPGLQQR	LRRRPGAPRP
RDVRSIFEQP	QDPRVPAERG	EGHCFAELVL	PGGPGWCDLC	GREVLRQALR
CTNCKFTCHP	ECRSLIQLDC	SQQEGLSRDR	PSPESTLTVT	FSQNVCKPVE
ETQRPPTLQE	IKQKIDSYNT	REKNCLGMKL	SEDGTYTGFI	KVHLKLRRPV
TVPAGIRPQS	IYDAIKEVNL	AATTDKRTSF	YLPLDAIKQL	HISSTTTVSE
VIQGLLKKFM	VVDNPQKFAL	FKRIHKDGQV	LFQKLSIADR	PLYLRLLAGP
DTEVLSFVLK	ENETGEVEWD	AFSIPELQNF	LTILEKEEQD	KIQQVQKKYD
KFRQKLEEAL	RESQGKPG

Funkcija[uredi | uredi izvor]

Ovaj gen je član porodice pridružene domenu Ras. Djeluje kao supresor tumora i inaktivira se kod raznih vrsta raka. Kodirani protein se lokalizira na centrosome i mikrotubule i povezuje se s GTP-aktiviranim oblicima Ras, Rap1 i nekoliko drugih malih GTPaza sličnih Ras. Protein reguliše adheziju limfocita i potiskuje rast ćelija kao odgovor na aktivirani Rap1 ili Ras. Za ovaj gen nađene su višestruke varijante transkripta koje kodiraju različite izoforme.^[7]

Interakcije[uredi | uredi izvor]

Pokazalo se da RASSF5 ima interakcije sa RRAS,^[9] RAP2A,^[9] MRAS^[9] i RASSF1.^[9]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000266094 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026430 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yao R, Wang Y, You M (Apr 2002). "Chromosome mapping and sequence variation of the murine Ras effector gene Nore1". Cytogenetics and Cell Genetics. 95 (1–2): 126–8. doi:10.1159/000057035. PMID 11978988. S2CID 26933977.
^ Tommasi S, Dammann R, Jin SG, Zhang XF, Avruch J, Pfeifer GP (Apr 2002). "RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1". Oncogene. 21 (17): 2713–20. doi:10.1038/sj.onc.1205365. PMID 11965544.
^ ^a ^b "Entrez Gene: RASSF5 Ras association (RalGDS/AF-6) domain family 5".
^ "UniProt, Q8WWW0" (jezik: engleski). Pristupljeno 17. 12. 2021.
^ ^a ^b ^c ^d Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.

Dopunska literatura[uredi | uredi izvor]

Kumari G, Singhal PK, Suryaraja R, Mahalingam S (Mar 2010). "Functional interaction of the Ras effector RASSF5 with the tyrosine kinase Lck: critical role in nucleocytoplasmic transport and cell cycle regulation". Journal of Molecular Biology. 397 (1): 89–109. doi:10.1016/j.jmb.2010.01.005. PMID 20064523.
Vavvas D, Li X, Avruch J, Zhang XF (Mar 1998). "Identification of Nore1 as a potential Ras effector". The Journal of Biological Chemistry. 273 (10): 5439–42. doi:10.1074/jbc.273.10.5439. PMID 9488663.
Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.
Khokhlatchev A, Rabizadeh S, Xavier R, Nedwidek M, Chen T, Zhang XF, Seed B, Avruch J (Feb 2002). "Identification of a novel Ras-regulated proapoptotic pathway". Current Biology. 12 (4): 253–65. doi:10.1016/S0960-9822(02)00683-8. PMID 11864565. S2CID 14053233.
Vos MD, Martinez A, Ellis CA, Vallecorsa T, Clark GJ (Jun 2003). "The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung". The Journal of Biological Chemistry. 278 (24): 21938–43. doi:10.1074/jbc.M211019200. PMID 12676952.
Katagiri K, Maeda A, Shimonaka M, Kinashi T (Aug 2003). "RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1". Nature Immunology. 4 (8): 741–8. doi:10.1038/ni950. PMID 12845325. S2CID 10588415.
Chen J, Lui WO, Vos MD, Clark GJ, Takahashi M, Schoumans J, Khoo SK, Petillo D, Lavery T, Sugimura J, Astuti D, Zhang C, Kagawa S, Maher ER, Larsson C, Alberts AS, Kanayama HO, Teh BT (Nov 2003). "The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas". Cancer Cell. 4 (5): 405–13. doi:10.1016/S1535-6108(03)00269-1. PMID 14667507.
Praskova M, Khoklatchev A, Ortiz-Vega S, Avruch J (Jul 2004). "Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras". The Biochemical Journal. 381 (Pt 2): 453–62. doi:10.1042/BJ20040025. PMC 1133852. PMID 15109305.
Irimia M, Fraga MF, Sanchez-Cespedes M, Esteller M (Nov 2004). "CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer". Oncogene. 23 (53): 8695–9. doi:10.1038/sj.onc.1207914. PMID 15378027.
Fujita H, Fukuhara S, Sakurai A, Yamagishi A, Kamioka Y, Nakaoka Y, Masuda M, Mochizuki N (Feb 2005). "Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes". The Journal of Biological Chemistry. 280 (6): 5022–31. doi:10.1074/jbc.M409701200. PMID 15569673.
Nakamura N, Carney JA, Jin L, Kajita S, Pallares J, Zhang H, Qian X, Sebo TJ, Erickson LA, Lloyd RV (Sep 2005). "RASSF1A and NORE1A methylation and BRAFV600E mutations in thyroid tumors". Laboratory Investigation. 85 (9): 1065–75. doi:10.1038/labinvest.3700306. PMID 15980887.
Foukakis T, Au AY, Wallin G, Geli J, Forsberg L, Clifton-Bligh R, Robinson BG, Lui WO, Zedenius J, Larsson C (Mar 2006). "The Ras effector NORE1A is suppressed in follicular thyroid carcinomas with a PAX8-PPARgamma fusion". The Journal of Clinical Endocrinology and Metabolism. 91 (3): 1143–9. doi:10.1210/jc.2005-1372. PMID 16352687.
Moshnikova A, Frye J, Shay JW, Minna JD, Khokhlatchev AV (Mar 2006). "The growth and tumor suppressor NORE1A is a cytoskeletal protein that suppresses growth by inhibition of the ERK pathway". The Journal of Biological Chemistry. 281 (12): 8143–52. doi:10.1074/jbc.M511837200. PMID 16421102.
Macheiner D, Heller G, Kappel S, Bichler C, Stättner S, Ziegler B, Kandioler D, Wrba F, Schulte-Hermann R, Zöchbauer-Müller S, Grasl-Kraupp B (Jul 2006). "NORE1B, a candidate tumor suppressor, is epigenetically silenced in human hepatocellular carcinoma". Journal of Hepatology. 45 (1): 81–9. doi:10.1016/j.jhep.2005.12.017. PMID 16516329.
Ishiguro K, Avruch J, Landry A, Qin S, Ando T, Goto H, Xavier R (Oct 2006). "Nore1B regulates TCR signaling via Ras and Carma1". Cellular Signalling. 18 (10): 1647–54. doi:10.1016/j.cellsig.2006.01.015. PMC 3204664. PMID 16520020.

Vanjski linkovi[uredi | uredi izvor]

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000266094 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026430 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11978988-5] Yao R, Wang Y, You M (Apr 2002). "Chromosome mapping and sequence variation of the murine Ras effector gene Nore1". Cytogenetics and Cell Genetics. 95 (1–2): 126–8. doi:10.1159/000057035. PMID 11978988. S2CID 26933977.

[pmid11965544-6] Tommasi S, Dammann R, Jin SG, Zhang XF, Avruch J, Pfeifer GP (Apr 2002). "RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1". Oncogene. 21 (17): 2713–20. doi:10.1038/sj.onc.1205365. PMID 11965544.

[entrez-7] "Entrez Gene: RASSF5 Ras association (RalGDS/AF-6) domain family 5".

[UniProt-8] "UniProt, Q8WWW0" (jezik: engleski). Pristupljeno 17. 12. 2021.

[pmid11857081-9] Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.

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