RCP9

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RCP9
Identifikatori
AliasiCRCP
Vanjski ID-jeviOMIM: 606121 MGI: 1100818 HomoloGene: 40587 GeneCards: CRCP
Lokacija gena (čovjek)
Hromosom 7 (čovjek)
Hrom.Hromosom 7 (čovjek)[1]
Hromosom 7 (čovjek)
Genomska lokacija za RCP9
Genomska lokacija za RCP9
Bend7q11.21Početak66,114,604 bp[1]
Kraj66,154,568 bp[1]
Lokacija gena (miš)
Hromosom 5 (miš)
Hrom.Hromosom 5 (miš)[2]
Hromosom 5 (miš)
Genomska lokacija za RCP9
Genomska lokacija za RCP9
Bend5|5 G1.3Početak130,058,131 bp[2]
Kraj130,089,630 bp[2]
Obrazac RNK ekspresije


Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija nucleotide binding
RNA polymerase III activity
DNA-directed 5'-3' RNA polymerase activity
GO:0001948, GO:0016582 protein binding
catalytic activity
calcitonin gene-related peptide receptor activity
Ćelijska komponenta citosol
membrana
Ćelijska membrana
Nukleoplazma
Akrozom
DNA polymerase III complex
Jedro
RNA polymerase III complex
nuclear DNA-directed RNA polymerase complex
RNA polymerase complex
Biološki proces immune system process
cell metabolism
defense response to virus
neuropeptide signaling pathway
transcription by RNA polymerase III
Urođeni imunski sistem
DNA-templated transcription, initiation
transcription initiation from RNA polymerase III promoter
positive regulation of type I interferon production
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001040647
NM_001040648
NM_001142414
NM_014478

NM_007761

RefSeq (bjelančevina)

NP_001035737
NP_001035738
NP_001135886
NP_055293

NP_031787

Lokacija (UCSC)Chr 7: 66.11 – 66.15 MbChr 5: 130.06 – 130.09 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Podjedinica RPC9 DNK-usmjerene RNK polimeraze III je enzim koji je kod ljudi kodiran genom CRCP.[5][6][7][8]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 148 aminokiselina, а molekulska težina 16.871 Da.[9]

1020304050
MEVKDANSALLSNYEVFQLLTDLKEQRKESGKNKHSSGQQNLNTITYETL
KYISKTPCRHQSPEIVREFLTALKSHKLTKAEKLQLLNHRPVTAVEIQLM
VEESEERLTEEQIEALLHTVTSILPAEPEAEQKKNTNSNVAMDEEDPA

Funkcija[uredi | uredi izvor]

Ovaj gen kodira membranski protein koji funkcionira kao dio receptorskog kompleksa za mali neuropeptid koji povećava unutarćelijske nivoe cAMP-a. Opisane su alternativno prerađene varijante transkripcije, koje kodiraju različite izoforme.[8]

Reference[uredi | uredi izvor]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000241258 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025532 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Luebke AE, Dahl GP, Roos BA, Dickerson IM (Jun 1996). "Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay". Proc Natl Acad Sci U S A. 93 (8): 3455–60. doi:10.1073/pnas.93.8.3455. PMC 39630. PMID 8622957.
  6. ^ Balkan W, Oates EL, Howard GA, Roos BA (Mar 1999). "Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein". Endocrinology. 140 (3): 1459–69. doi:10.1210/en.140.3.1459. PMID 10067875.
  7. ^ Siaut M, Zaros C, Levivier E, Ferri ML, Court M, Werner M, Callebaut I, Thuriaux P, Sentenac A, Conesa C (Dec 2002). "An Rpb4/Rpb7-Like Complex in Yeast RNA Polymerase III Contains the Orthologue of Mammalian CGRP-RCP". Mol Cell Biol. 23 (1): 195–205. doi:10.1128/MCB.23.1.195-205.2003. PMC 140662. PMID 12482973.
  8. ^ a b "Entrez Gene: RCP9 calcitonin gene-related peptide-receptor component protein".
  9. ^ "UniProt, O75575" (jezik: engleski). Pristupljeno 28. 9. 2021.

Dopunska literatura[uredi | uredi izvor]

Vanjski linkovi[uredi | uredi izvor]