S Wikipedije, slobodne enciklopedije
Regeneracijski protein 4 izveden iz otočića jest protein koji je kod ljudi kodiran genom REG4 sa hromosoma 1 .[5] [6] [7]
Dužina polipeptidnog lanca je 158 aminokiselina , a molekulska težina Da . 18 230[8]
10 20 30 40 50 MASRSMRLLL LLSCLAKTGV LGDIIMRPSC APGWFYHKSN CYGYFRKLRN WSDAELECQS YGNGAHLASI LSLKEASTIA EYISGYQRSQ PIWIGLHDPQ KRQQWQWIDG AMYLYRSWSG KSMGGNKHCA EMSSNNNFLT WSSNECNKRQ HFLCKYRP
^ a b c GRCh38: Ensembl release 89: ENSG00000134193 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027876 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Hartupee JC, Zhang H, Bonaldo MF, Soares MB, Dieckgraefe BK (Apr 2001). "Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV". Biochim Biophys Acta . 1518 (3): 287–93. doi :10.1016/s0167-4781(00)00284-0 . PMID 11311942 . ^ Violette S, Festor E, Pandrea-Vasile I, Mitchell V, Adida C, Dussaulx E, Lacorte JM, Chambaz J, Lacasa M, Lesuffleur T (Nov 2002). "Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas" . Int J Cancer . 103 (2): 185–93. doi :10.1002/ijc.10788 PMID 12455032 . ^ "Entrez Gene: REG4 regenerating islet-derived family, member 4" .^ "UniProt, Q9BYZ8" (jezik: eng.). Pristupljeno 4. 12. 2021 .CS1 održavanje: nepoznati jezik (link )
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Kämäräinen M, Heiskala K, Knuutila S, et al. (2003). "RELP, a Novel Human Reg-Like Protein with Up-Regulated Expression in Inflammatory and Metaplastic Gastrointestinal Mucosa" . Am. J. Pathol . 163 (1): 11–20. doi :10.1016/S0002-9440(10)63625-5 . PMC 1868159 PMID 12819006 . Zhang Y, Lai M, Lv B, et al. (2003). "Overexpression of Reg IV in colorectal adenoma". Cancer Lett . 200 (1): 69–76. doi :10.1016/S0304-3835(03)00460-9 . PMID 14550954 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites" . Protein Sci . 13 (10): 2819–24. doi :10.1110/ps.04682504 . PMC 2286551 PMID 15340161 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Gu Z, Rubin MA, Yang Y, et al. (2005). "Reg IV: a promising marker of hormone refractory metastatic prostate cancer" . Clin. Cancer Res . 11 (6): 2237–43. doi :10.1158/1078-0432.CCR-04-0356 PMID 15788672 . Bishnupuri KS, Luo Q, Murmu N, et al. (2006). "Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas" . Gastroenterology . 130 (1): 137–49. doi :10.1053/j.gastro.2005.10.001 . PMID 16401477 . Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1" . Nature . 441 (7091): 315–21. Bibcode :2006Natur.441..315G . doi :10.1038/nature04727 PMID 16710414 . Takehara A, Eguchi H, Ohigashi H, et al. (2006). "Novel tumor marker REG4 detected in serum of patients with resectable pancreatic cancer and feasibility for antibody therapy targeting REG4" . Cancer Sci . 97 (11): 1191–7. doi :10.1111/j.1349-7006.2006.00297.x PMID 16918991 . 
