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U enzimologiji , sve-trans-retinol 13,14-reduktaza (1.3.99.23 ) je enzim , koji je kod ljudi kodiran genom RETSAT sa hromosoma 2 .[5] [6] [7] Katalizira hemijsku reakciju
sve-trans-13,14-dihidroretinol + akceptor
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{\displaystyle \rightleftharpoons }
reducirani akceptor Dakle, dva supstrata ovog enzima su sve-trans-13,14-dihidroretinol i akceptor , dok su njegova dva proizvoda sve-trans-retinol i reducirani akceptor . U fiziološkim uslovima, reakcija se odvija u suprotnom smjeru katalizirajući zasićenje 13-14 dvostruke veze sve-trans-retinola .
Dužina polipeptidnog lanca je 610 aminokiselina , a molekulska težina 66.820 Da .[8]
10 20 30 40 50 MWLPLVLLLA VLLLAVLCKV YLGLFSGSSP NPFSEDVKRP PAPLVTDKEA RKKVLKQAFS ANQVPEKLDV VVIGSGFGGL AAAAILAKAG KRVLVLEQHT KAGGCCHTFG KNGLEFDTGI HYIGRMEEGS IGRFILDQIT EGQLDWAPLS SPFDIMVLEG PNGRKEYPMY SGEKAYIQGL KEKFPQEEAI IDKYIKLVKV VSSGAPHAIL LKFLPLPVVQ LLDRCGLLTR FSPFLQASTQ SLAEVLQQLG ASSELQAVLS YIFPTYGVTP NHSAFSMHAL LVNHYMKGGF YPRGGSSEIA FHTIPVIQRA GGAVLTKATV QSVLLDSAGK ACGVSVKKGH ELVNIYCPIV VSNAGLFNTY EHLLPGNARC LPGVKQQLGT VRPGLGMTSV FICLRGTKED LHLPSTNYYV YYDTDMDQAM ERYVSMPREE AAEHIPLLFF AFPSAKDPTW EDRFPGRSTM IMLIPTAYEW FEEWQAELKG KRGSDYETFK NSFVEASMSV VLKLFPQLEG KVESVTAGSP LTNQFYLAAP RGACYGADHD LGRLHPCVMA SLRAQSPIPN LYLTGQDIFT CGLVGALQGA LLCSSAILKR NLYSDLKNLD SRIRAQKKKN
Ovaj enzim pripada porodici oksidoreduktaza , posebno onih koji djeluju na CH-CH grupu donora sa drugim akceptorima. Sistematski naziv ove klase enzima je sve-trans-13,14-dihidroretinol:akceptor 13,14-oksidoreduktaze . Drugi nazivi u uobičajenoj upotrebi uključuju retinol saturaza , RetSat , (13,14)-sve-trans-retinol saturaza i sve-trans- retinol:sve-trans-13,14-dihidroretinol saturaza .
Gen je također nazvan PPAR-alfa-reguliranim genskim proteinom koji je izazvan gladovanjem.[9]
^ a b c GRCh38: Ensembl release 89: ENSG00000042445 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056666 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment" . Genome Res . 13 (10): 2265–70. doi :10.1101/gr.1293003 . PMC 403697 PMID 12975309 . ^ Moise AR, Kuksa V, Imanishi Y, Palczewski K (Nov 2004). "Identification of All-trans-Retinol:All-trans-13,14-dihydroretinol Saturase*" . J Biol Chem . 279 (48): 50230–42. doi :10.1074/jbc.M409130200 PMC 2665716 PMID 15358783 . ^ "Entrez Gene: RETSAT retinol saturase (all-trans-retinol 13,14-reductase)" .^ "UniProt, Q6NUM9" (jezik: engleski). Pristupljeno 14. 11. 2021 .^ "RETSAT - All-trans-retinol 13,14-reductase precursor - Homo sapiens (Human) - RETSAT gene & protein" . www.uniprot.org (jezik: engleski). Pristupljeno 5. 11. 2017 .
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