RIPK2

RIPK2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4C8B, 2N7Z, 5AR3, 5AR2, 5AR7, 5AR8, 5AR5, 5AR4, 2N83, 5J7B, 5J79
Identifikatori
Aliasi	RIPK2
Vanjski ID-jevi	OMIM: 603455 MGI: 1891456 HomoloGene: 37856 GeneCards: RIPK2
EC broj	2.7.10.2
Lokacija gena (čovjek)
Hrom.	Hromosom 8 (čovjek)
Kraj	89,791,064 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	16,163,647 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• LIM domain binding; • kinase activity; • CARD domain binding; • signaling receptor binding; • ATP binding; • protein kinase activity; • non-membrane spanning protein tyrosine kinase activity; • transferase activity; • protein homodimerization activity; • GO:0001948, GO:0016582 vezivanje za proteine; • nucleotide binding; • signal transducer activity; • protein serine/threonine kinase activity; • vezivanje identičnih proteina; • caspase binding; • JUN kinase kinase kinase activity;
Ćelijska komponenta	• citoplazma; • citoskelet; • Vezikula; • citosol; • GO:0009327 makromolekulani kompleks;
Biološki proces	• response to interleukin-1; • positive regulation of cytokine-mediated signaling pathway; • response to exogenous dsRNA; • positive regulation of JNK cascade; • positive regulation of xenophagy; • cellular response to muramyl dipeptide; • protein phosphorylation; • positive regulation of ERK1 and ERK2 cascade; • cellular response to peptidoglycan; • positive regulation of stress-activated MAPK cascade; • GO:0051637 defense response to Gram-positive bacterium; • GO:0097285 apoptoza; • regulation of apoptotic process; • positive regulation of immature T cell proliferation; • positive regulation of interleukin-12 production; • positive regulation of interferon-alpha production; • positive regulation of peptidyl-serine phosphorylation; • JNK cascade; • response to interleukin-12; • nucleotide-binding oligomerization domain containing 2 signaling pathway; • positive regulation of T-helper 1 type immune response; • positive regulation of alpha-beta T cell proliferation; • positive regulation of interleukin-6 production; • positive regulation of tumor necrosis factor production; • positive regulation of peptidyl-tyrosine phosphorylation; • inflammatory response; • I-kappaB kinase/NF-kappaB signaling; • nucleotide-binding oligomerization domain containing 1 signaling pathway; • positive regulation of interferon-beta production; • Fosforilacija; • immune system process; • positive regulation of T-helper 1 cell differentiation; • negative regulation of apoptotic process; • cellular response to lipoteichoic acid; • positive regulation of interleukin-2 production; • positive regulation of chemokine production; • nucleotide-binding oligomerization domain containing signaling pathway; • positive regulation of protein ubiquitination; • lipopolysaccharide-mediated signaling pathway; • positive regulation of interferon-gamma production; • T cell proliferation; • positive regulation of peptidyl-threonine phosphorylation; • positive regulation of apoptotic process; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • peptidyl-tyrosine phosphorylation; • cellular response to lipopolysaccharide; • T cell receptor signaling pathway; • response to interleukin-18; • GO:0072468 Transdukcija signala; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • toll-like receptor 4 signaling pathway; • toll-like receptor 2 signaling pathway; • Urođeni imunski sistem; • MAPK cascade; • adaptive immune response; • positive regulation of protein binding; • positive regulation of NF-kappaB transcription factor activity; • activation of cysteine-type endopeptidase activity; • positive regulation of cell death; • interleukin-1-mediated signaling pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	8767
	192656
	ENSG00000104312
	ENSMUSG00000041135
	O43353
	P58801
	NM_003821; NM_001375360
	NM_138952; NM_001329751
	NP_003812; NP_001362289
	NP_001316680; NP_620402
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Receptor-interaktivna serin/treonine-protein kinaza 2 jest enzim koji je kod ljudi kodiran genom RIPK2 sa hromosoma 8.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 540 aminokiselina, a molekulska težina 61.195 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MNGEAICSAL	PTIPYHKLAD	LRYLSRGASG	TVSSARHADW	RVQVAVKHLH
IHTPLLDSER	KDVLREAEIL	HKARFSYILP	ILGICNEPEF	LGIVTEYMPN
GSLNELLHRK	TEYPDVAWPL	RFRILHEIAL	GVNYLHNMTP	PLLHHDLKTQ
NILLDNEFHV	KIADFGLSKW	RMMSLSQSRS	SKSAPEGGTI	IYMPPENYEP
GQKSRASIKH	DIYSYAVITW	EVLSRKQPFE	DVTNPLQIMY	SVSQGHRPVI
NEESLPYDIP	HRARMISLIE	SGWAQNPDER	PSFLKCLIEL	EPVLRTFEEI
TFLEAVIQLK	KTKLQSVSSA	IHLCDKKKME	LSLNIPVNHG	PQEESCGSSQ
LHENSGSPET	SRSLPAPQDN	DFLSRKAQDC	YFMKLHHCPG	NHSWDSTISG
SQRAAFCDHK	TTPCSSAIIN	PLSTAGNSER	LQPGIAQQWI	QSKREDIVNQ
MTEACLNQSL	DALLSRDLIM	KEDYELVSTK	PTRTSKVRQL	LDTTDIQGEE
FAKVIVQKLK	DNKQMGLQPY	PEILVVSRSP	SLNLLQNKSM

Funkcija[uredi | uredi izvor]

Ovaj gen kodira člana porodice proteina serin/treonin protein-kinaza s interakcijom s receptorom (RIP). Kodirani protein sadrži C-terminalni domen regrutacije kaspaze (CARD) i komponenta je signalnih kompleksa, kako u urođenom tako iu adaptivnom imunskom putu. Potentan je aktivator NF-κB i induktor apoptoze kao odgovor na različite podražaje.^[7]

Interakcije[uredi | uredi izvor]

Pokazalo se da RIPK2 reaguje sa BIRC2.^[6]^[8]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104312 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041135 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Inohara N, del Peso L, Koseki T, Chen S, Nunez G (Jun 1998). "RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis". J Biol Chem. 273 (20): 12296–300. doi:10.1074/jbc.273.20.12296. PMID 9575181.
^ ^a ^b Thome M, Hofmann K, Burns K, Martinon F, Bodmer JL, Mattmann C, Tschopp J (Nov 1998). "Identification of CARDIAK, a RIP-like kinase that associates with caspase-1". Curr Biol. 8 (15): 885–8. doi:10.1016/S0960-9822(07)00352-1. PMID 9705938. S2CID 1235278.
^ ^a ^b ^c "Entrez Gene: RIPK2 receptor-interacting serine-threonine kinase 2".
^ McCarthy, J V; Ni J; Dixit V M (Jul 1998). "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase". J. Biol. Chem. United States. 273 (27): 16968–75. doi:10.1074/jbc.273.27.16968. ISSN 0021-9258. PMID 9642260.

Dopunska literatura[uredi | uredi izvor]

Medzhitov R, Janeway C (2000). "Innate immune recognition: mechanisms and pathways". Immunol. Rev. 173: 89–97. doi:10.1034/j.1600-065X.2000.917309.x. PMID 10719670. S2CID 20844121.
Dufner A, Mak TW (2006). "CARD tricks: controlling the interactions of CARD6 with RICK and microtubules". Cell Cycle. 5 (8): 797–800. doi:10.4161/cc.5.8.2635. PMID 16582588.
McCarthy JV, Ni J, Dixit VM (1998). "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase". J. Biol. Chem. 273 (27): 16968–75. doi:10.1074/jbc.273.27.16968. PMID 9642260.
Bertin J, Nir WJ, Fischer CM, et al. (1999). "Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB". J. Biol. Chem. 274 (19): 12955–8. doi:10.1074/jbc.274.19.12955. PMID 10224040.
Inohara N, Koseki T, del Peso L, et al. (1999). "Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB". J. Biol. Chem. 274 (21): 14560–7. doi:10.1074/jbc.274.21.14560. PMID 10329646.
Navas TA, Baldwin DT, Stewart TA (1999). "RIP2 is a Raf1-activated mitogen-activated protein kinase kinase". J. Biol. Chem. 274 (47): 33684–90. doi:10.1074/jbc.274.47.33684. PMID 10559258.
Inohara N, Koseki T, Lin J, et al. (2000). "An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways". J. Biol. Chem. 275 (36): 27823–31. doi:10.1074/jbc.M003415200. PMID 10880512.
Ogura Y, Inohara N, Benito A, et al. (2001). "Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB". J. Biol. Chem. 276 (7): 4812–8. doi:10.1074/jbc.M008072200. PMID 11087742.
Lee SH, Stehlik C, Reed JC (2001). "Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing". J. Biol. Chem. 276 (37): 34495–500. doi:10.1074/jbc.M101415200. PMID 11432859.
Khursigara G, Bertin J, Yano H, et al. (2001). "A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2". J. Neurosci. 21 (16): 5854–63. doi:10.1523/JNEUROSCI.21-16-05854.2001. PMC 6763175. PMID 11487608.
Andersson L, Scharin Tang M (2015). "Rip2 modifies VEGF-induced signalling and vascular permeability in myocardial ischaemia". Cardiovasc. Res. 107 (4): 478–86. doi:10.1093/cvr/cvv186. PMID 26130752.
Druilhe A, Srinivasula SM, Razmara M, et al. (2001). "Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins". Cell Death Differ. 8 (6): 649–57. doi:10.1038/sj.cdd.4400881. PMID 11536016.
Chin AI, Dempsey PW, Bruhn K, et al. (2002). "Involvement of receptor-interacting protein 2 in innate and adaptive immune responses". Nature. 416 (6877): 190–4. Bibcode:2002Natur.416..190C. doi:10.1038/416190a. PMID 11894097. S2CID 4405035.
Kobayashi K, Inohara N, Hernandez LD, et al. (2002). "RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems" (PDF). Nature. 416 (6877): 194–9. Bibcode:2002Natur.416..194K. doi:10.1038/416194a. hdl:2027.42/62842. PMID 11894098. S2CID 4363636.
Munz B, Hildt E, Springer ML, Blau HM (2002). "RIP2, a Checkpoint in Myogenic Differentiation". Mol. Cell. Biol. 22 (16): 5879–86. doi:10.1128/MCB.22.16.5879-5886.2002. PMC 133983. PMID 12138198.
Yoo NJ, Park WS, Kim SY, et al. (2003). "Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1". Biochem. Biophys. Res. Commun. 299 (4): 652–8. doi:10.1016/S0006-291X(02)02714-6. PMID 12459189.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chen YR, Clark AC (2003). "Equilibrium and kinetic folding of an alpha-helical Greek key protein domain: caspase recruitment domain (CARD) of RICK". Biochemistry. 42 (20): 6310–20. doi:10.1021/bi0340752. PMID 12755636.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104312 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041135 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9575181-5] Inohara N, del Peso L, Koseki T, Chen S, Nunez G (Jun 1998). "RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis". J Biol Chem. 273 (20): 12296–300. doi:10.1074/jbc.273.20.12296. PMID 9575181.

[pmid9705938-6] Thome M, Hofmann K, Burns K, Martinon F, Bodmer JL, Mattmann C, Tschopp J (Nov 1998). "Identification of CARDIAK, a RIP-like kinase that associates with caspase-1". Curr Biol. 8 (15): 885–8. doi:10.1016/S0960-9822(07)00352-1. PMID 9705938. S2CID 1235278.

[entrez-7] "Entrez Gene: RIPK2 receptor-interacting serine-threonine kinase 2".

[pmid9642260-8] McCarthy, J V; Ni J; Dixit V M (Jul 1998). "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase". J. Biol. Chem. United States. 273 (27): 16968–75. doi:10.1074/jbc.273.27.16968. ISSN 0021-9258. PMID 9642260.

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