RPL10A
60S ribosomni protein L10a jest protein koji je kod ljudi kodiran genom RPL10A .[5][6][7]
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 217 aminokiselina, а molekulska težina 24.831 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSSKVSRDTL | YEAVREVLHG | NQRKRRKFLE | TVELQISLKN | YDPQKDKRFS | ||||
| GTVRLKSTPR | PKFSVCVLGD | QQHCDEAKAV | DIPHMDIEAL | KKLNKNKKLV | ||||
| KKLAKKYDAF | LASESLIKQI | PRILGPGLNK | AGKFPSLLTH | NENMVAKVDE | ||||
| VKSTIKFQMK | KVLCLAVAVG | HVKMTDDELV | YNIHLAVNFL | VSLLKKNWQN | ||||
| VRALYIKSTM | GKPQRLY |
Funkcija[uredi | uredi izvor]
Ribosomi, organele koje kataliziraju sintezu proteina, sastoje se od male 40S i velike 60S podjedinice. Ove se podjedinice zajedno sastoje od četiri tipa RNK i približno 80 strukturno različitih proteina. Ovaj gen kodira ribosomski protein koji je komponenta podjedinice 60S. Protein pripada porodici ribosomalnih proteina L1P. Nalazi se u citoplazmi. Ekspresija ovog gena smanjena je u timusu, pomoću ciklosporin-A (CsA), imunosupresivnog lijeka.
Studije na miševima pokazale su da je ekspresija gena ribsomnog proteina L10a snižena u neuronskim ćelijama prekursorima tokom razvoja. Ovaj gen se nekada nazivao NEDD6 (ćelija eksprimiranog neuronskog prekursora, razvojno smanjena 6), ali je preimenovan u RPL10A (ribosomski protein 10a). Kao što je tipsko za gene koji kodiraju ribosomske proteine, postoji više obrađenih pseudogena ovog gena raspršenih širom genoma.[7]
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000198755 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037805 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Fisicaro N, Katerelos M, Williams J, Power D, D'Apice A, Pearse M (Aug 1995). "Identification of genes downregulated in the thymus by cyclosporin-A: preliminary characterization of clone CSA-19". Mol Immunol. 32 (8): 565–72. doi:10.1016/0161-5890(95)00032-A. PMID 7609734.
- ^ Tripodis N, Mason R, Humphray SJ, Davies AF, Herberg JA, Trowsdale J, Nizetic D, Senger G, Ragoussis J (Jan 1999). "Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex". Genome Res. 8 (6): 631–43. doi:10.1101/gr.8.6.631. PMC 310739. PMID 9647638.
- ^ a b "Entrez Gene: RPL10A ribosomal protein L10a".
- ^ "UniProt, P62906" (jezik: engleski). Pristupljeno 4. 10. 2021.
Dopunska literatura[uredi | uredi izvor]
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- Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384. S2CID 12847618.
- Olvera J, Wool IG (1996). "The primary structure of rat ribosomal protein L10a". Biochem. Biophys. Res. Commun. 220 (3): 954–7. doi:10.1006/bbrc.1996.0513. PMID 8607874.
- Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
- Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Koga M, Shichijo S, Yamada A, et al. (2004). "Identification of ribosomal proteins S2 and L10a as tumor antigens recognized by HLA-A26-restricted CTL". Tissue Antigens. 61 (2): 136–45. doi:10.1046/j.0001-2815.2002.00009.x. PMID 12694581.
- Odintsova TI, Müller EC, Ivanov AV, et al. (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". J. Protein Chem. 22 (3): 249–58. doi:10.1023/A:1025068419698. PMID 12962325. S2CID 10710245.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
- Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.