SARNP

SARNP
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2DO1
Identifikatori
Aliasi	SARNP
Vanjski ID-jevi	OMIM: 610049 MGI: 1913368 HomoloGene: 41628 GeneCards: SARNP
Lokacija gena (miš)
Hrom.	Hromosom 10 (miš)
Kraj	128,877,629 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje sa RNK; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • protein C-terminus binding; • RS domain binding;
Ćelijska komponenta	• nuclear speck; • transcription export complex; • jedro; • nukleoplazma; • cytoplasmic ribonucleoprotein granule;
Biološki proces	• mRNA transport; • GO:0009373 regulation of transcription, DNA-templated; • regulation of translation; • transcription, DNA-templated; • RNA export from nucleus; • mRNA export from nucleus; • termination of RNA polymerase II transcription; • mRNA 3'-end processing; • GO:0015915 transport; • GO:1901227 negative regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	84324
	66118
	n/a
	ENSMUSG00000078427
	P82979
	Q9D1J3
	NM_033082
	NM_025364
	NP_149073
NP_079640; NP_001346332; NP_001346333; NP_001346334; NP_001346335;
	NP_001346336
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

SAP ribonukleoprotein sa domenom je protein koji je kod ljudi kodiran genom SARNP.^[4]^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 210 aminokiselina, a molekulska težina 23.671 Da.^[7].

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MATETVELHK	LKLAELKQEC	LARGLETKGI	KQDLIHRLQA	YLEEHAEEEA
NEEDVLGDET	EEEETKPIEL	PVKEEEPPEK	TVDVAAEKKV	VKITSEIPQT
ERMQKRAERF	NVPVSLESKK	AARAARFGIS	SVPTKGLSSD	NKPMVNLDKL
KERAQRFGLN	VSSISRKSED	DEKLKKRKER	FGIVTSSAGT	GTTEDTEAKK
RKRAERFGIA

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000078427 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Choong ML, Tan LK, Lo SL, Ren EC, Ou K, Ong SE, Liang RC, Seow TK, Chung MC (maj 2001). "An integrated approach in the discovery and characterization of a novel nuclear protein over-expressed in liver and pancreatic tumors". FEBS Lett. 496 (2–3): 109–16. doi:10.1016/S0014-5793(01)02409-7. PMID 11356193. S2CID 24122700.
^ Fukuda S, Wu DW, Stark K, Pelus LM (Mar 2002). "Cloning and characterization of a proliferation-associated cytokine-inducible protein, CIP29". Biochem Biophys Res Commun. 292 (3): 593–600. doi:10.1006/bbrc.2002.6680. PMID 11922608.
^ "Entrez Gene: CIP29 cytokine induced protein 29 kDa".
^ "UniProt, P82979". Pristupljeno 14. 8. 2021.

Dopunska literatura[uredi | uredi izvor]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Navakauskiene R, Treigyte G, Gineitis A, Magnusson KE (2004). "Identification of apoptotic tyrosine-phosphorylated proteins after etoposide or retinoic acid treatment". Proteomics. 4 (4): 1029–41. doi:10.1002/pmic.200300671. PMID 15048984. S2CID 26389150.
Hashii Y, Kim JY, Sawada A, et al. (2004). "A novel partner gene CIP29 containing a SAP domain with MLL identified in infantile myelomonocytic leukemia". Leukemia. 18 (9): 1546–8. doi:10.1038/sj.leu.2403450. PMID 15284855.
Leaw CL, Ren EC, Choong ML (2004). "Hcc-1 is a novel component of the nuclear matrix with growth inhibitory function". Cell. Mol. Life Sci. 61 (17): 2264–73. doi:10.1007/s00018-004-4205-x. PMID 15338056. S2CID 19729441.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Sugiura T, Sakurai K, Nagano Y (2007). "Intracellular characterization of DDX39, a novel growth-associated RNA helicase". Exp. Cell Res. 313 (4): 782–90. doi:10.1016/j.yexcr.2006.11.014. PMID 17196963.

Vanjski linkovi[uredi | uredi izvor]

Lokacija ljudskog genoma SARNP i stranica sa detaljima o genu SARNP u UCSC Genome Browseru.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000078427 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11356193-4] Choong ML, Tan LK, Lo SL, Ren EC, Ou K, Ong SE, Liang RC, Seow TK, Chung MC (maj 2001). "An integrated approach in the discovery and characterization of a novel nuclear protein over-expressed in liver and pancreatic tumors". FEBS Lett. 496 (2–3): 109–16. doi:10.1016/S0014-5793(01)02409-7. PMID 11356193. S2CID 24122700.

[pmid11922608-5] Fukuda S, Wu DW, Stark K, Pelus LM (Mar 2002). "Cloning and characterization of a proliferation-associated cytokine-inducible protein, CIP29". Biochem Biophys Res Commun. 292 (3): 593–600. doi:10.1006/bbrc.2002.6680. PMID 11922608.

[entrez-6] "Entrez Gene: CIP29 cytokine induced protein 29 kDa".

[UniProt-7] "UniProt, P82979". Pristupljeno 14. 8. 2021.

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