SART1

SART1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 4PYU
Identifikatori
Aliasi	SART1
Vanjski ID-jevi	OMIM: 605941 MGI: 1309453 HomoloGene: 133770 GeneCards: SART1
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek) Bend 11q13.1 Početak 65,961,728 bp Kraj 65,980,137 bp
Lokacija gena (miš) Hrom. Hromosom 19 (miš) Bend 19|19 A Početak 5,427,551 bp Kraj 5,438,731 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje sa RNK Ćelijska komponenta • citoplazma • citosol • Cajal body • Golđijev aparat • U4/U6 x U5 tri-snRNP complex • catalytic step 2 spliceosome • spliceosomal complex • jedro • nukleoplazma • nuclear speck • U2-type precatalytic spliceosome Biološki proces • mRNA cis splicing, via spliceosome • positive regulation of cytotoxic T cell differentiation • intrinsic apoptotic signaling pathway • mRNA splicing, via spliceosome • mRNA processing • maturation of 5S rRNA • spliceosomal snRNP assembly • Prerada RNK Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	9092	20227
Ensembl	ENSG00000175467	ENSMUSG00000039148
UniProt	O43290	Q9Z315
RefSeq (mRNK)	NM_005146	NM_016882
RefSeq (bjelančevina)	NP_005137	NP_058578
Lokacija (UCSC)	Chr 11: 65.96 – 65.98 Mb	Chr 19: 5.43 – 5.44 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

U4/U6.U5 tri-snRNP-pridruženi protein 1 je protein koji je kod ljudi kodiran genom SART1.

Ovaj gen kodira dva proteina, protein SART1 (800) eksprimiran u u jedru većine ćelija koje se razmnožavaju i protein SART1 (259) u citosolu epitelnog karcinoma. SART1 (259) protein prevodi se mehanizmom-1 pomjeranja okvira tokom posttranskripcijske regulacije. Smatra se da su dva kodirana proteina uključena u regulaciju proliferacije. Oba proteina imaju odbacivanje tumorskih antigena. Protein SART1 (259) ima tumorski epitop koji je sposoban inducirati HLA-A24 02 ograničene citotoksične T-limfocite u pacijenata s rakom. Ovaj SART1 (259) antigen može biti koristan u specifičnoj imunoterapiji za oboljele od raka i može poslužiti kao paradigmatski alat za dijagnostiku i liječenje pacijenata sa atopijom. Utvrđeno je da je protein SART1 (259) bitan za regrutiranje tri-snRNP u presplajsosomu na putunjegovog sklapanja.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 800 aminokiselina, а molekulska težina 90.255 Da.

10		20		30		40		50
MGSSKKHRGE		KEAAGTTAAA		GTGGATEQPP		RHREHKKHKH		RSGGSGGSGG
ERRKRSRERG		GERGSGRRGA		EAEARSSTHG		RERSQAEPSE		RRVKREKRDD
GYEAAASSKT		SSGDASSLSI		EETNKLRAKL		GLKPLEVNAI		KKEAGTKEEP
VTADVINPMA		LRQREELREK		LAAAKEKRLL		NQKLGKIKTL		GEDDPWLDDT
AAWIERSRQL		QKEKDLAEKR		AKLLEEMDQE		FGVSTLVEEE		FGQRRQDLYS
ARDLQGLTVE		HAIDSFREGE		TMILTLKDKG		VLQEEEDVLV		NVNLVDKERA
EKNVELRKKK		PDYLPYAEDE		SVDDLAQQKP		RSILSKYDEE		LEGERPHSFR
LEQGGTADGL		RERELEEIRA		KLRLQAQSLS		TVGPRLASEY		LTPEEMVTFK
KTKRRVKKIR		KKEKEVVVRA		DDLLPLGDQT		QDGDFGSRLR		GRGRRRVSEV
EEEKEPVPQP		LPSDDTRVEN		MDISDEEEGG		APPPGSPQVL		EEDEAELELQ
KQLEKGRRLR		QLQQLQQLRD		SGEKVVEIVK		KLESRQRGWE		EDEDPERKGA
IVFNATSEFC		RTLGEIPTYG		LAGNREEQEE		LMDFERDEER		SANGGSESDG
EENIGWSTVN		LDEEKQQQDF		SASSTTILDE		EPIVNRGLAA		ALLLCQNKGL
LETTVQKVAR		VKAPNKSLPS		AVYCIEDKMA		IDDKYSRREE		YRGFTQDFKE
KDGYKPDVKI		EYVDETGRKL		TPKEAFRQLS		HRFHGKGSGK		MKTERRMKKL
DEEALLKKMS		SSDTPLGTVA		LLQEKQKAQK		TPYIVLSGSG		KSMNANTITK

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

Dopunska literatura

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