SASH1

SASH1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2EBP
Identifikatori
Aliasi	SASH1
Vanjski ID-jevi	OMIM: 607955 MGI: 1917347 HomoloGene: 69182 GeneCards: SASH1
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	148,552,044 bp
Lokacija gena (miš)
Hrom.	Hromosom 10 (miš)
Kraj	8,761,814 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• mitogen-activated protein kinase kinase kinase binding; • GO:0032947 molecular adaptor activity; • protein C-terminus binding; • protein kinase binding;
Ćelijska komponenta	• GO:0009327 makromolekulani kompleks;
Biološki proces	• positive regulation of endothelial cell migration; • positive regulation of lipopolysaccharide-mediated signaling pathway; • positive regulation of JUN kinase activity; • regulation of protein K63-linked ubiquitination; • positive regulation of p38MAPK cascade; • regulation of protein autoubiquitination; • protein polyubiquitination; • positive regulation of NIK/NF-kappaB signaling; • positive regulation of angiogenesis;
	Izvori:Amigo / QuickGO
Ortolozi
	23328
	70097
	ENSG00000111961
	ENSMUSG00000015305
	O94885
	P59808
NM_015278; NM_001346505; NM_001346506; NM_001346507; NM_001346508;
	NM_001346509
	NM_175155
NP_001333434; NP_001333435; NP_001333436; NP_001333437; NP_001333438;
	NP_056093
	NP_780364
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 1 sa SAM i SH3 domenom jest protein koji je kod ljudi kodiran genom SASH1.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 1.247 aminokiselina, а molekulska težina 136.653 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MEDAGAAGPG	PEPEPEPEPE	PEPAPEPEPE	PKPGAGTSEA	FSRLWTDVMG
ILDGSLGNID	DLAQQYADYY	NTCFSDVCER	MEELRKRRVS	QDLEVEKPDA
SPTSLQLRSQ	IEESLGFCSA	VSTPEVERKN	PLHKSNSEDS	SVGKGDWKKK
NKYFWQNFRK	NQKGIMRQTS	KGEDVGYVAS	EITMSDEERI	QLMMMVKEKM
ITIEEALARL	KEYEAQHRQS	AALDPADWPD	GSYPTFDGSS	NCNSREQSDD
ETEESVKFKR	LHKLVNSTRR	VRKKLIRVEE	MKKPSTEGGE	EHVFENSPVL
DERSALYSGV	HKKPLFFDGS	PEKPPEDDSD	SLTTSPSSSS	LDTWGAGRKL
VKTFSKGESR	GLIKPPKKMG	TFFSYPEEEK	AQKVSRSLTE	GEMKKGLGSL
SHGRTCSFGG	FDLTNRSLHV	GSNNSDPMGK	EGDFVYKEVI	KSPTASRISL
GKKVKSVKET	MRKRMSKKYS	SSVSEQDSGL	DGMPGSPPPS	QPDPEHLDKP
KLKAGGSVES	LRSSLSGQSS	MSGQTVSTTD	SSTSNRESVK	SEDGDDEEPP
YRGPFCGRAR	VHTDFTPSPY	DTDSLKLKKG	DIIDIISKPP	MGTWMGLLNN
KVGTFKFIYV	DVLSEDEEKP	KRPTRRRRKG	RPPQPKSVED	LLDRINLKEH
MPTFLFNGYE	DLDTFKLLEE	EDLDELNIRD	PEHRAVLLTA	VELLQEYDSN
SDQSGSQEKL	LVDSQGLSGC	SPRDSGCYES	SENLENGKTR	KASLLSAKSS
TEPSLKSFSR	NQLGNYPTLP	LMKSGDALKQ	GQEEGRLGGG	LAPDTSKSCD
PPGVTGLNKN	RRSLPVSICR	SCETLEGPQT	VDTWPRSHSL	DDLQVEPGAE
QDVPTEVTEP	PPQIVPEVPQ	KTTASSTKAQ	PLEQDSAVDN	ALLLTQSKRF
SEPQKLTTKK	LEGSIAASGR	GLSPPQCLPR	NYDAQPPGAK	HGLARTPLEG
HRKGHEFEGT	HHPLGTKEGV	DAEQRMQPKI	PSQPPPVPAK	KSRERLANGL
HPVPMGPSGA	LPSPDAPCLP	VKRGSPASPT	SPSDCPPALA	PRPLSGQAPG
SPPSTRPPPW	LSELPENTSL	QEHGVKLGPA	LTRKVSCARG	VDLETLTENK
LHAEGIDLTE	EPYSDKHGRC	GIPEALVQRY	AEDLDQPERD	VAANMDQIRV
KQLRKQHRMA	IPSGGLTEIC	RKPVSPGCIS	SVSDWLISIG	LPMYAGTLST
AGFSTLSQVP	SLSHTCLQEA	GITEERHIRK	LLSAARLFKL	PPGPEAM

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111961 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015305 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
^ Zeller C, Hinzmann B, Seitz S, Prokoph H, Burkhard-Goettges E, Fischer J, Jandrig B, Schwarz LE, Rosenthal A, Scherneck S (maj 2003). "SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is downregulated in breast cancer". Oncogene. 22 (19): 2972–83. doi:10.1038/sj.onc.1206474. PMID 12771949.
^ "Entrez Gene: SASH1 SAM and SH3 domain containing 1".
^ "UniProt, O94885" (jezik: engleski). Pristupljeno 10. 10. 2021.

Dopunska literatura[uredi | uredi izvor]

Rimkus C, Martini M, Friederichs J, et al. (2007). "Prognostic significance of downregulated expression of the candidate tumour suppressor gene SASH1 in colon cancer". Br. J. Cancer. 95 (10): 1419–23. doi:10.1038/sj.bjc.6603452. PMC 2360597. PMID 17088907.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID 15790807. S2CID 13047538.
Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

Vanjski linkovi[uredi | uredi izvor]

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000111961 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015305 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9872452-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.

[pmid12771949-6] Zeller C, Hinzmann B, Seitz S, Prokoph H, Burkhard-Goettges E, Fischer J, Jandrig B, Schwarz LE, Rosenthal A, Scherneck S (maj 2003). "SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is downregulated in breast cancer". Oncogene. 22 (19): 2972–83. doi:10.1038/sj.onc.1206474. PMID 12771949.

[entrez-7] "Entrez Gene: SASH1 SAM and SH3 domain containing 1".

[UniProt-8] "UniProt, O94885" (jezik: engleski). Pristupljeno 10. 10. 2021.

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