SCGB1D2

SCGB1D2
Identifikatori
Aliasi	SCGB1D2
Vanjski ID-jevi	OMIM: 615061 HomoloGene: 88740 GeneCards: SCGB1D2
Lokacija gena (čovjek)
Hrom.	Hromosom 11 (čovjek)
Kraj	62,244,812 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ortolozi
	10647
	n/a
	ENSG00000124935
	n/a
	O95969
	n/a
	NM_006551
	n/a
	NP_006542
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Član 2 sekretoglobinske porodice 1D je protein koji je kod ljudi kodiran genom SCGB1D2.^[3]^[4]^[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 90 aminokiselina, а molekulska težina Da. 9 925^[6]

10		20		30		40		50
MKLSVCLLLV		TLALCCYQAN		AEFCPALVSE		LLDFFFISEP		LFKLSLAKFD
APPEAVAAKL		GVKRCTDQMS		LQKRSLIAEV		LVKILKKCSV

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

Funkcija[uredi | uredi izvor]

Protein kodiran ovim genom član je potporodice lipofilina, dio potporodice uteroglobina i ortolog je prostateina, glavnog sekretornog glikoproteina ventralnog dijrls pacovske prostate. Proizvodi gena lipofilina široko su eksprimirani u normalnim tkivima, posebno u organima koji odgovaraju na endokrini sistem. Pretpostavljajući da su ljudski lipofilini funkcionalni pandani prostate, oni se mogu transkripcijski regulirati steroidnim hormonima, sa sposobnošću vezanja androgena, drugih steroida i mogućeg vezivanja i koncentriranja estramustina, hemoterapijskog sredstva koje se široko koristi za rak prostate. Iako je prijavljeno da je gen na hromosomu 10, čini se da je ova sekvenca iz grupe gena na hromosomu 11, koja uključuje mamaglobin 2.^[5]

Ekspresija SCGB1D2-a je velika u tkivu dojke, a ponekad se koristi za identifikaciju i detekciju diseminiranih ćelija raka dojke.^[7]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124935 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhao C, Nguyen T, Yusifov T, Glasgow BJ, Lehrer RI (mart 1999). "Lipophilins: human peptides homologous to rat prostatein". Biochemical and Biophysical Research Communications. 256 (1): 147–55. doi:10.1006/bbrc.1999.0274. PMID 10066439.
^ Lehrer RI, Xu G, Abduragimov A, Dinh NN, Qu XD, Martin D, Glasgow BJ (august 1998). "Lipophilin, a novel heterodimeric protein of human tears". FEBS Letters. 432 (3): 163–7. doi:10.1016/S0014-5793(98)00852-7. PMID 9720917. S2CID 205880914.
^ ^a ^b "Entrez Gene: SCGB1D2 secretoglobin, family 1D, member 2".
^ "UniProt, O95969". Pristupljeno 27. 8. 2021.
^ Lacroix M (decembar 2006). "Significance, detection and markers of disseminated breast cancer cells". Endocrine-Related Cancer. Bioscientifica. 13 (4): 1033–67. doi:10.1677/ERC-06-0001. PMID 17158753.

Dopunska literatura[uredi | uredi izvor]

Culleton J, O'Brien N, Ryan BM, Hill AD, McDermott E, O'Higgins N, Duffy MJ (mart 2007). "Lipophilin B: A gene preferentially expressed in breast tissue and upregulated in breast cancer". International Journal of Cancer. 120 (5): 1087–92. doi:10.1002/ijc.22471. PMID 17163411. S2CID 20729571.
Sjödin A, Guo D, Lund-Johansen M, Krossnes BK, Lilleng P, Henriksson R, Hedman H (april 2005). "Secretoglobins in the human pituitary: high expression of lipophilin B and its down-regulation in pituitary adenomas". Acta Neuropathologica. 109 (4): 381–6. doi:10.1007/s00401-004-0972-6. PMID 15668787. S2CID 20395605.
Carter D, Dillon DC, Reynolds LD, Retter MW, Fanger G, Molesh DA, Sleath PR, McNeill PD, Vedvick TS, Reed SG, Persing DH, Houghton RL (februar 2003). "Serum antibodies to lipophilin B detected in late stage breast cancer patients". Clinical Cancer Research. 9 (2): 749–54. PMID 12576445.
Carter D, Douglass JF, Cornellison CD, Retter MW, Johnson JC, Bennington AA, Fleming TP, Reed SG, Houghton RL, Diamond DL, Vedvick TS (maj 2002). "Purification and characterization of the mammaglobin/lipophilin B complex, a promising diagnostic marker for breast cancer". Biochemistry. 41 (21): 6714–22. doi:10.1021/bi0159884. PMID 12022875.

Vanjski linkovi[uredi | uredi izvor]

Microarray study results where SCGB1D2 is significantly up or downregulated^{[mrtav link]}

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124935 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10066439-3] Zhao C, Nguyen T, Yusifov T, Glasgow BJ, Lehrer RI (mart 1999). "Lipophilins: human peptides homologous to rat prostatein". Biochemical and Biophysical Research Communications. 256 (1): 147–55. doi:10.1006/bbrc.1999.0274. PMID 10066439.

[pmid9720917-4] Lehrer RI, Xu G, Abduragimov A, Dinh NN, Qu XD, Martin D, Glasgow BJ (august 1998). "Lipophilin, a novel heterodimeric protein of human tears". FEBS Letters. 432 (3): 163–7. doi:10.1016/S0014-5793(98)00852-7. PMID 9720917. S2CID 205880914.

[entrez-5] "Entrez Gene: SCGB1D2 secretoglobin, family 1D, member 2".

[UniProt-6] "UniProt, O95969". Pristupljeno 27. 8. 2021.

[Lacroix06-7] Lacroix M (decembar 2006). "Significance, detection and markers of disseminated breast cancer cells". Endocrine-Related Cancer. Bioscientifica. 13 (4): 1033–67. doi:10.1677/ERC-06-0001. PMID 17158753.

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